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Volume 24, Issue 12
  • ISSN: 1566-5240
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Abstract

Objectives

Polypyrimidine tract binding protein is a 57-Kda protein located in the perinucleolar compartment where it binds RNA and regulates several biological functions through the regulation of RNA splicing. Numerous research articles have been published that address the cellular network and functions of PTB and its isoforms in various disease states.

Methodology

Through an extensive PubMed search, we attempt to summarize the relevant research into this biomolecule.

Results

Besides its roles in embryonic development, neuronal cell growth, RNA metabolism, apoptosis, and hematopoiesis, PTB can affect cancer growth several metabolic, proliferative, and structural mechanisms. PTB overexpression has been documented in several cancers where it plays a role as a novel prognostic factor.

Conclusion

The diverse carcinogenic effect opens an argument into its potential role in inhibitory targeted therapy.

© 2024 Bentham Science Publishers
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2024-12-01
2024-11-26

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/content/journals/cmm/10.2174/0115665240251370231017053236
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Polypyrimidine Tract Binding Protein: A Universal Player in Cancer Development
Current Molecular Medicine 24, 1450 (2024); https://doi.org/10.2174/0115665240251370231017053236
/content/journals/cmm/10.2174/0115665240251370231017053236
/content/journals/cmm/10.2174/0115665240251370231017053236
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  • Article Type:     Review Article
Keyword(s): apoptosis; cancer; hematopoiesis; PNC; Polypyrimidine tract binding protein; RNA splicing

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