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2000
Volume 19, Issue 12
  • ISSN: 1573-4056
  • E-ISSN: 1875-6603

Abstract

Objective: to investigate the feasibility of gadoxetic acid (Gd-EOB-DTPA) enhanced MRI combined with T1 mapping in quantitative hepatic function assessment. Methods: this study retrospectively enrolled 94 patients with Gd-EOB-DTPA enhanced MRI combined with T1 mapping, divided into group A (grade A, n=73), group B (grade B, n=14) and group C (grade C, n=7) based on Child-Pugh classification. Liver T1 relaxation times on plain scan (T1) and hepatocellular phase (T1) were measured. Decrease in T1 (T1) and the percentage of decrease in T1 (T1%) were calculated as follows: T1=T1-T1, T1%= T1/T1×100%. The relationship between T1, T1, T1, T1% and liver function classification was analyzed. Results: T1, T1, and T1% in group A were significantly higher than those of group B and C. T1 in group A was lower than those of group B and C. T1% was significantly different between group B and C. There was no significant difference in T1, T1, T1 between groups B and C. T1 was positively correlated with liver function levels, T1 and T1 had a negative correlation with liver function levels. T1, T1, T1, T1% were significantly different between cirrhotic and non-cirrhotic groups. T1% of less than 70% suggests liver dysfunction. Conclusion: Gd-EOB-DTPA enhanced liver MRI combined with T1 mapping is feasible for quantitative assessment of hepatic function.

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/content/journals/cmir/10.2174/1573405619666230113115748
2023-10-01
2025-07-08
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