Current Medicinal Chemistry - Volume 9, Issue 14, 2002

Studies on enzyme inhibition remain an important area of pharmaceutical research since these studies have led to the discoveries of drugs useful in a variety of physiological conditions. The enzyme inhibitors can interact with enzymes and block their activity towards natural substrates. Urease inhibitors have recently attracted much attention as potential new anti-ulcer drugs. Ironically, urease was the first enzyme crystallized b Read More

Endogenous histamine regulates the haematopoiesis. Histidine decarboxylase inhibitor decreases the histamine level, and its intracellular antagonist decreases the histamine effect. The effect of histidine decarboxylase inhibitor (α-fluoromethyl histidine) and the intracellular antagonist of histamine [NN-diethyl-2-4-(phenylmethyl) phenoxyethan-amine-HCl] was investigated on the colonyforming ability of human peripher Read More

The purpose of this paper was to examine the effects of speech therapy and various pharmacological treatment approaches on the voice and speech of persons with Parkinson's disease (PD). Approximately 80% of PD patients have voice and speech problems including reduced vocal intensity, reduced vocal pitch, monopitch and monoloudness, and imprecise articulation. Research prior to 1970s had not demonstrated Read More

The continuous raise of molecular diversity requires to find a guidelines for orientation it this. A likely occasion for consideration of new QSAR approach possibilities for this aspect is the flavonoids (F) multitude, the class of organic compounds (C) with very varied chemistry and pharmacology. The list of F affinities includes benzodiazepines, adenosine, estrogen receptors and row of enzymes - phosphodiesterase, Read More

Because of the physiological role played by the hyperpolarisation process resulting from a K+ outflow, it is not surprising that compounds able to activate outward K+ channels are considered as promising drugs, with exciting perspectives for the treatment of several cardiovascular, respiratory, neurological and urological diseases. Among the different and numerous K+ channel families, medicinal chemistry has focu Read More

In the last few years, new drugs for the treatment of schizophrenia have been introduced in therapy which have noticeably improved the quality of life of many schizophrenic patients. These new "atypical" drugs have chemical, pharmacological and clinical properties which are different from those of the classical neuroleptics. The most used drugs among the "atypical" antipsychotics are clozapine, olanzapine, quetiapine and ri Read More