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- Volume 30, Issue 20, 2023
Current Medicinal Chemistry - Volume 30, Issue 20, 2023
Volume 30, Issue 20, 2023
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The Role of High-density Lipoprotein in Oral and Dental Diseases
High-density lipoprotein (HDL) is the smallest and densest of the lipoproteins. Beyond its well-known cardiovascular protective function, it has other actions, including structural function, anti-inflammatory, antioxidant, anti-thrombotic effects, transport of bioactive molecules, and induction of signal transduction pathways. Further, there is a mutual connection between oral health and general health. Hence HDL could be a pote Read More
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Research Progress in Pharmacological Mechanisms, Structure-Activity Relationship and Synthesis of Sartans
Authors: Ye-Fan Wang, Xin-Yue Ren, Wen Zhang and Guo-Wu RaoThe sartans are a new class of antihypertensive drugs as angiotensin II receptor blockers which possess plenty of advantages in treating hypertension and related pathologies. This review describes the clinical treatment, side effects, and potential therapeutic effects of sartans from 1995 to date. The synthesis, structural-activity and molecular docking with Angiotensin Type 1 receptor of imidazole derivatives, benzimi Read More
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Hybrid Histone Deacetylase Inhibitor: An Effective Strategy for Cancer Therapy
Authors: Jiyong Wu, Jing Nie, Yepeng Luan and Yanjiao DingInhibition of histone deacetylases (HDACs) has proven to be an effective strategy for cancer therapy. To date, five histone deacetylase inhibitors (HDACis) have been approved for cancer treatment, and numerous others are undergoing clinical trials. An agent that can simultaneously and effectively inhibit two or more targets may offer greater therapeutic benefits over single-acting agents in preventing resistance to treat Read More
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Curcumin Combats against Organophosphate Pesticides Toxicity: A Review of the Current Evidence and Molecular Pathways
Organophosphate compounds are regarded as a class of pesticides that are used in farming. Their extensive use, especially in developing countries, is a serious public health problem. Numerous studies have shown the effects of these toxins on various parts of the human and other vertebrates’ bodies, including the cardiovascular, hepatobiliary, renal, and reproductive systems. Curcumin is a polyphenol compound o Read More
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The Functions of EphA1 Receptor Tyrosine Kinase in Several Tumors
Authors: Yinxin Wu, Zhuoying Du, Jie Mou, Xinyan Qiu, Jinlan Chen, Sanjin Cai, Dongming Ren, Fangxiang Xiao, Gang Zhou and Chengfu YuanBackground: Eph receptors tyrosine kinase (RTK) were identified in 1987 from hepatocellular carcinoma cell lines and were the largest known subfamily of RTK. Eph receptors can be divided into two categories, EphA and EphB, based on their structure and receptor-ligand specificity. EphA can be divided into 10 species (EphA 1-10) and EphB into 6 species (EphB1-6). Similarly, the ligands of Eph receptors are Ephrins. Ephrin Read More
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Volumes & issues
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Volume 32 (2025)
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Volume 31 (2024)
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Volume 30 (2023)
- Issue 40
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- Issue 38
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- Issue 17
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- Issue 14
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- Issue 12
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- Issue 3
- Issue 2
- Issue 1
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Volume 29 (2022)
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Volume 28 (2021)
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Volume 27 (2020)
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Volume 26 (2019)
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Volume 25 (2018)
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Volume 24 (2017)
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Volume 23 (2016)
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Volume 22 (2015)
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Volume 21 (2014)
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Volume 20 (2013)
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Volume 19 (2012)
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Volume 18 (2011)
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Volume 17 (2010)
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Volume 16 (2009)
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Volume 15 (2008)
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Volume 14 (2007)
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Volume 13 (2006)
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Volume 12 (2005)
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Volume 11 (2004)
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Volume 10 (2003)
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Volume 9 (2002)
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Volume 8 (2001)
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Volume 7 (2000)
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