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- Volume 28, Issue 14, 2021
Current Medicinal Chemistry - Volume 28, Issue 14, 2021
Volume 28, Issue 14, 2021
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A Comprehensive Overview of Colon Cancer- A Grim Reaper of the 21st Century
Authors: Rajesh Kumar, Seetha Harilal, Simone Carradori and Bijo MathewA few decades ago, the incidence of colorectal cancer (CRC) was low and is now the fourth in the list of deadly cancers producing nearly a million deaths annually. A population that is aging along with risk factors such as smoking, obesity, sedentary lifestyle with little or no physical activity, and non-healthy food habits of developed countries can increase the risk of colorectal cancer. The balance in gut microbiota and the metab Read More
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Advancing the Therapeutic Efficacy of Bioactive Molecules by Delivery Vehicle Platforms
Authors: Antonis D. Tsiailanis, Andreas G. Tzakos and Thomas MavromoustakosDrugs have to overcome numerous barriers to reach their desired therapeutic targets. In several cases, drugs, especially the highly lipophilic molecules, suffer from low solubility and bioavailability and therefore their desired targeting is hampered. In addition, undesired metabolic products might be produced or off-targets could be recognized. Along these lines, nanopharmacology has provided new technological platforms, Read More
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Copper-Induced Epigenetic Changes Shape the Clinical Phenotype in Wilson’s Disease
Wilson's disease is a congenital disorder of copper metabolism whose pathogenesis remains, at least in part, unknown. Subjects carrying the same genotype may show completely different phenotypes, differing for the age at illness onset or for the hepatic, neurologic or psychiatric clinical presentation. The inability to find a unequivocal correlation between the type of mutation in the ATPase copper transporting beta (ATP7B Read More
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Mitophagy: A Novel Therapeutic Target for Treating DN
Authors: Ming Yang, Chenrui Li, Shikun Yang, Ying Xiao, Wei Chen, Peng Gao, Na Jiang, Shan Xiong, Ling Wei, Qin Zhang, Jinfei Yang, Lingfeng Zeng and Lin SunDiabetic nephropathy (DN) is a common microvascular complication of diabetes and one of the leading causes of end-stage renal disease. Tubular damage is an early change and characteristic of DN, and mitochondrial dysfunction plays an important role in the development of DN. Therefore, the timely removal of damaged mitochondria in tubular cells is an effective treatment strategy for DN. Mitophagy is a type of selective a Read More
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NMR Spectroscopy in the Conformational Analysis of Peptides: An Overview
Authors: Marian Vincenzi, Flavia A. Mercurio and Marilisa LeoneBackground: NMR spectroscopy is one of the most powerful tools to study the structure and interaction properties of peptides and proteins from a dynamic perspective. Knowing the bioactive conformations of peptides is crucial in the drug discovery field to design more efficient analogue ligands and inhibitors of protein-protein interactions targeting therapeutically relevant systems. Objective: This review provides a toolkit Read More
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Transcriptional Dysregulation in Huntington’s Disease: The Role in Pathogenesis and Potency for Pharmacological Targeting
Authors: Aleksandra Pogoda, Natalia Chmielewska, Piotr Maciejak and Janusz SzyndlerHuntington’s disease (HD) is an inherited neurodegenerative disorder caused by a mutation in the gene that encodes a critical cell regulatory protein, huntingtin (Htt). The expansion of cytosine-adenine-guanine (CAG) trinucleotide repeats causes improper folding of functional proteins and is an initial trigger of pathological changes in the brain. Recent research has indicated that the functional dysregulation of many transcri Read More
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Tanshinones: An Update in the Medicinal Chemistry in Recent 5 Years
Authors: Zhencheng Lai, Jixiao He, Changxin Zhou, Huajun Zhao and Sunliang CuiTanshinones are an important type of natural products isolated from Salvia miltiorrhiza Bunge with various bioactivities. Tanshinone IIa, cryptotanshinone and tanshinone I are three kinds of tanshinones which have been widely investigated. Particularly, sodium tanshinone IIa sulfonate is a water-soluble derivative of tanshinone IIa and it is used in clinical in China for treating cardiovascular diseases. In recent y Read More
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Biosensors and Bioanalytical Devices based on Magnetic Particles: A Review
More LessMagnetic particles play an important role in current technology, and this field of technology extends to a broader progression. The term magnetic particles typically cover the paramagnetic particles and super-paramagnetic particles. Various materials like iron oxide are common, but other materials are available as well; a survey of such materials has been included in this work. They can serve for technological purposes like Read More
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Dysfunctional High-density Lipoprotein: The Role of Myeloperoxidase and Paraoxonase-1
Low circulating high-density lipoproteins (HDL) are not only defining criteria for metabolic syndrome, but are more generally associated with atherosclerotic cardiovascular disease (ASCVD) and other chronic diseases. Oxidative stress, a hallmark of cardio-metabolic disease, further influences HDL activity by suppressing their function. Especially the leukocyte- derived enzyme myeloperoxidase (MPO) has recently attr Read More
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Volumes & issues
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Volume 32 (2025)
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Volume 31 (2024)
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Volume 30 (2023)
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Volume 29 (2022)
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Volume 28 (2021)
- Issue 42
- Issue 41
- Issue 40
- Issue 39
- Issue 38
- Issue 37
- Issue 36
- Issue 35
- Issue 34
- Issue 33
- Issue 32
- Issue 31
- Issue 30
- Issue 29
- Issue 28
- Issue 27
- Issue 26
- Issue 25
- Issue 24
- Issue 23
- Issue 22
- Issue 21
- Issue 20
- Issue 19
- Issue 18
- Issue 17
- Issue 16
- Issue 15
- Issue 14
- Issue 13
- Issue 12
- Issue 11
- Issue 10
- Issue 9
- Issue 8
- Issue 7
- Issue 6
- Issue 5
- Issue 4
- Issue 3
- Issue 2
- Issue 1
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Volume 27 (2020)
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Volume 26 (2019)
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Volume 25 (2018)
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Volume 24 (2017)
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Volume 23 (2016)
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Volume 22 (2015)
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Volume 21 (2014)
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Volume 20 (2013)
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Volume 19 (2012)
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Volume 18 (2011)
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Volume 17 (2010)
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Volume 16 (2009)
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Volume 15 (2008)
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Volume 14 (2007)
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Volume 13 (2006)
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Volume 12 (2005)
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Volume 11 (2004)
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Volume 10 (2003)
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Volume 9 (2002)
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Volume 8 (2001)
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Volume 7 (2000)
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