Current Medicinal Chemistry - Volume 24, Issue 31, 2017

Background: Family B G protein-coupled receptors (GPCRs) play an important role in many physiological and pathophysiological processes. They are plasma-membrane proteins containing an extracellular N-domain, an intracellular C-tail, seven transmembrane domains (TMs), three extracellular (ELs) and three intracellular (ILs) loops. Objective: This review aims to summarize the current structural and functional info Read More

Background: Research on Chromogranin A (CGA) and its derived fragments convincingly demonstrated the multifunctional activity of the 21 amino acid peptide named Catestatin (CST: human CGA352-372, bovine CGA344-364, rat CGA367-387). This review aims to provide a synopsis of the current information concerning the biological role of CST in health and disease. Methods: Structured search of bibliographic databases f Read More

More than 100 years ago, German physician Paul Ehrlich first proposed the concept of selectively delivering “magic bullets” to tumors through targeting agents. The targeting therapy with antibody-drug conjugates (ADCs) and peptide-drug conjugate (PDCs), which are usually composed of monoclonal antibodies or peptides, toxic payloads and cleavage/ noncleavage linkers, has been extensively studied for decades. The con Read More

Background: Diabetic nephropathy is one of the most important complications in patients with diabetes mellitus. Main steps crucial for the pathogenesis of diabetic nephropathy involve amongst others the modulation of cell signaling via AMP-activated kinase (AMPK) and mammalian target of rapamycin (mTOR), reactive oxygen generation, and endoplasmic reticulum stress under diabetic or hyperglycemic conditions. Read More

Background: Therapeutic angiogenesis is a clinical intervention for controlled stimulation and augmentation of neovascularisation in ischemic tissues. Conventional therapeutic techniques involve proangiogenic factor based induction of host tissue angiogenesis. In this review, we provide a holistic idea about therapeutic angiogenesis while specifically highlighting the role of proangiogenic factors as growth factors, peptides, Read More