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- Volume 23, Issue 16, 2016
Current Medicinal Chemistry - Volume 23, Issue 16, 2016
Volume 23, Issue 16, 2016
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Mesenchymal Stem Cells for Ischemic Stroke: Progress and Possibilities
Stroke is the most common neurological cause of morbidity and mortality in industrialized countries, afflicting 15 million people every year. The numbers are expected to increase, mostly due to aging populations. One in five stroke patients dies, and one in three are left with permanent disabilities. Although some acute phase therapies such as intravenous recombinant tissue plasminogen activator (rt-PA) andendovascula Read More
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Onychomycosis and its Chemotherapy
Authors: Anwer Basha, Fatima Basha, Syed K. Ali, Paul R. Hanson, Berl R. Oakley, Heather Hajovsky and Lester A. MitscherOnychomycosis (fungal nail infections) is very common worldwide but is fortunately not often lethal. Several powerful drugs have been introduced into clinical practice in recent years, but these infections remain difficult to cure primarily due to the difficulty of penetration of drug to the site of the infection in therapeutic concentrations. The nature of the disease, the causative fungi, and the characteristics of the drugs employe Read More
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Is Nitric Oxide Assuming a Janus-Face in The Central Nervous System?
Authors: Felicity Ockelford, Louis Saada, Ehud Gazit and Achala de MelNitric Oxide, synthesized from L-arginine by the nitric oxide synthases, has a complex role within the human body. It contributes to almost every physiological system and has been found to be both protective and toxic in disease states. An aging population faces an increasing incidence of neurodegenerative disease and the pathological action of nitric oxide in Alzheimer’s and Parkinson’s diseases may be important therape Read More
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Current Techniques for Studying Oligomer Formations of G-Protein-Coupled Receptors Using Mammalian and Yeast Cells
Authors: Yasuyuki Nakamura, Jun Ishii and Akihiko KondoG-protein-coupled receptors (GPCRs) are physiologically important transmembrane proteins that sense signaling molecules such as hormones, neurotransmitters, and various sensory stimuli; GPCRs represent major molecular targets for drug discovery. Although GPCRs traditionally have been thought to function as monomers or homomers, in the recent years these proteins have also been shown to function as heterome Read More
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Management of Inflammation by Natural Polyphenols: A Comprehensive Mechanistic Update
Authors: Souvik Sarkar, Somnath Mazumder, Shubhra J. Saha and Uday BandyopadhyayInflammation generates a systemic response against injury or infection from bacteria, viruses, and other pathogens. The welfare of host is the primary target of this process. However, uncontrolled or inadequate regulation of the inflammatory response produces detrimental effects leading to the generation of various chronic disorders including atherosclerosis, type-2 diabetes, neurodegenerative disease, cancer and Alzhei Read More
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Volumes & issues
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Volume 32 (2025)
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Volume 31 (2024)
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Volume 30 (2023)
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Volume 29 (2022)
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Volume 28 (2021)
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Volume 27 (2020)
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Volume 26 (2019)
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Volume 25 (2018)
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Volume 24 (2017)
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Volume 23 (2016)
- Issue 42
- Issue 41
- Issue 40
- Issue 39
- Issue 38
- Issue 37
- Issue 36
- Issue 35
- Issue 34
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- Issue 32
- Issue 31
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- Issue 15
- Issue 12
- Issue 14
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- Issue 11
- Issue 10
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- Issue 8
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- Issue 5
- Issue 4
- Issue 3
- Issue 2
- Issue 1
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Volume 22 (2015)
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Volume 21 (2014)
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Volume 20 (2013)
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Volume 19 (2012)
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Volume 18 (2011)
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Volume 17 (2010)
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Volume 16 (2009)
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Volume 15 (2008)
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Volume 14 (2007)
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Volume 13 (2006)
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Volume 12 (2005)
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Volume 11 (2004)
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Volume 10 (2003)
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Volume 9 (2002)
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Volume 8 (2001)
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Volume 7 (2000)
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