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- Volume 21, Issue 36, 2014
Current Medicinal Chemistry - Volume 21, Issue 36, 2014
Volume 21, Issue 36, 2014
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Accessing Targeted Nanoparticles to the Brain: The Vascular Route
Authors: A. Burkhart, M. Azizi, M.S. Thomsen, L.B. Thomsen and T. MoosThe blood-brain barrier (BBB), formed by brain capillary endothelial cells, prevents the entry of several drug molecules to the brain, especially molecules hydrophilic in nature. Advanced drug carriers like nanoparticles share the potential to allow entry of therapeutic proteins and genetic molecules into the central nervous system (CNS). Taking a targeting approach by conjugating molecules acting as ligands or monoclonal Read More
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Diagnostic and Therapeutic Uses of Nanomaterials in the Brain
More LessNanomedicine has recently emerged as an exciting tool able to improve the early diagnosis and treatment of a variety of intractable or age-related brain disorders. The most relevant properties of nanomaterials are that they can be engineered to cross the blood brain barrier, to target specific cells and molecules and to act as vehicles for drugs. Potentially beneficial properties of nanotherapeutics derived from its unique charac Read More
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Colloidal Supramolecular Aggregates for Therapeutic Application in Neuromedicine
Neuromedicine has recently been emerging on the research scene and presents interesting challenges in therapeutics. The range of therapies generally used to treat neurological disorders are limited in their efficacy and degree of patient compliance because of the necessity of multiple drug dosages, low drug concentration in the central nervous system and side effects. Moreover, therapeutics require standard drug dos Read More
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Nanomedicine Based Nanoparticles for Neurological Disorders
Authors: Bhasker Sriramoju, Rupinder K. Kanwar and Jagat R. KanwarHuman health is severely hampered by a majority of the neurological disorders such as the brain tumors, degenerative Alzheimer’s disease, Parkinson’s disease and those involving inflammatory component. Owing to the stringent protection offered by the blood brain barrier, conventional therapeutics gain limited access and therefore, are therapeutically suboptimal. Hence, research has now focused to develop the novel d Read More
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Nanotechnology and Alzheimer’s Disease: What has been Done and What to Do’
Authors: B. Ruozi, D. Belletti, F. Pederzoli, P. Veratti, F. Forni, M.A. Vandelli and G. TosiUp to date, Alzheimer’s Disease (AD) is considered as an “urgency” for public health, since it represents one of the most dramatic causes of death in adults. The drugs currently used for AD are only symptomatic, thus not curing the pathology, but only trying to slow or delay the progression of the pathology. Moreover, there is a total lack of early identification, with only “probable’’ or ‘‘possible’’ diagnosis of AD patients. With thi Read More
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Development of HIV Reservoir Targeted Long Acting Nanoformulated Antiretroviral Therapies
Authors: Benson J. Edagwa, Tian Zhou, JoEllyn M. McMillan, Xin-Ming Liu and Howard E. GendelmanHuman immunodeficiency virus (HIV) infection commonly results in a myriad of comorbid conditions secondary to immune deficiency. Infection also affects broad organ system function. Although current antiretroviral therapy (ART) reduces disease morbidity and mortality through effective control of peripheral viral load, restricted infection in HIV reservoirs including gut, lymphoid and central nervous system tissues, is not eli Read More
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Volumes & issues
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Volume 32 (2025)
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Volume 31 (2024)
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Volume 30 (2023)
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Volume 29 (2022)
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Volume 28 (2021)
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Volume 27 (2020)
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Volume 26 (2019)
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Volume 25 (2018)
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Volume 24 (2017)
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Volume 23 (2016)
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Volume 22 (2015)
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Volume 21 (2014)
- Issue 38
- Issue 37
- Issue 36
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- Issue 2
- Issue 1
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Volume 20 (2013)
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Volume 19 (2012)
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Volume 18 (2011)
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Volume 17 (2010)
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Volume 16 (2009)
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Volume 15 (2008)
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Volume 14 (2007)
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Volume 13 (2006)
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Volume 12 (2005)
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Volume 11 (2004)
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Volume 10 (2003)
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Volume 9 (2002)
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Volume 8 (2001)
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Volume 7 (2000)
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