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- Volume 14, Issue 28, 2007
Current Medicinal Chemistry - Volume 14, Issue 28, 2007
Volume 14, Issue 28, 2007
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Mannose 6-Phosphate Receptor Targeting and its Applications in Human Diseases
Authors: M. Gary-Bobo, P. Nirde, A. Jeanjean, A. Morere and M. GarciaThe cation-independent mannose 6-phosphate receptor is a multifunctional protein which binds at the cell surface to two distinct classes of ligands, the mannose 6-phosphate (M6P) bearing proteins and IGF-II. Its major function is to bind and transport M6Penzymes to lysosomes, but it can also modulate the activity of a variety of extracellular M6P-glycoproteins (i.e., latent TGFβ precursor, urokinase-type plasminogen activator r Read More
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The Molecular Basis of Susceptibility to Infection in Liver Cirrhosis
More LessThere is much clinical evidence of a relationship between infectious disease and chronic liver disease. The consequences of this adverse association have been described and advances in the treatment and prophylaxis of infectious disease have had an important effect on the management of patients with chronic liver disease. The association between infectious disease and chronic liver disease involves altered cytokine produc Read More
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Microtubule-Stabilizing Natural Products as Promising Cancer Therapeutics
More LessPaclitaxel and related taxanes exhibit their anticancer activity by promoting tubulin polymerization and stabilizing microtubules, which results in mitotic G2/M arrest and apoptosis. The clinical success of paclitaxel in treating a wide array of tumor types has led to numerous efforts to identify novel natural products with paclitaxel-like mechanisms of action, but which may overcome some of the liabilities of the taxanes. Althoug Read More
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Oxidative RNA Damage and Neurodegeneration
Authors: A. Nunomura, P. I. Moreira, A. Takeda, M. A. Smith and G. PerryAlthough cellular RNA should be subject to the same oxidative insults as DNA and other cellular macromolecules, oxidative damage to RNA has not been a major focus in investigating the magnitude and the biological consequences of the free radical damage. However, because RNA is mostly single-stranded and its bases are not protected by hydrogen bonding and are less protected by specific proteins, RNA may be more susc Read More
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Towards the Development of a Broadly Protective Group A Streptococcal Vaccine Based on the Lipid-Core Peptide System
Authors: C. Olive, P. M. Moyle and I. TothPreclinical studies carried out over the last seven years by our group have focused on the development of a group A streptococcal (GAS) vaccine based on the antiphagocytic bacterial surface M protein using the Lipid-Core Peptide (LCP) system. This synthetic peptide vaccine delivery system has several advantages over other delivery systems including its self-adjuvanting properties and the ability to incorporate multiple pepti Read More
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Serotonin and Cognitive Flexibility: Neuroimaging Studies into the Effect of Acute Tryptophan Depletion in Healthy Volunteers
Authors: E. A.T. Evers, F. M. van der Veen, D. Fekkes and J. JollesCognitive flexibility is the ability to adjust behavior to changes in the environment or task conditions. Previous research suggested that serotonin (5-HT) is involved in cognitive flexibility. Disturbed 5-HT functioning in animals, psychiatric patients and healthy volunteers leads to more rigid behavior. A well recognized method to manipulate levels of brain 5-HT is acute tryptophan depletion (ATD). This method induces a transient and r Read More
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Recent Developments in Studies of l-Stepholidine and its Analogs: Chemistry, Pharmacology and Clinical Implications
Authors: Jiao Mo, Yang Guo, Yu-She Yang, Jing-Shan Shen, Guo-Zhang Jin and Xuechu ZhenTetrahydroprotoberberines (THPBs) represent a series of compounds extracted from the Chinese herb Corydalis ambigua and various species of Stephania. THPBs, dependent on the presence of hydroxyl groups in its structure, are divided into three types: nonhydroxyl- THPBs, monohydroxyl-THPBs and dihydroxyl-THPBs. THPBs are identified as a new category of dopamine receptor ligands. Among all THPBs, dihydroxyl-THPBs Read More
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Predictive Models for hERG Channel Blockers: Ligand-Based and Structure-Based Approaches
Authors: Khac-Minh Thai and Gerhard F. EckerAcquired long QT syndrome caused by drugs that block the human ether-a-go-go-related-gene (hERG) K+ channel causes severe side effects and thus represents a major problem in clinical studies of drug candidates. Therefore, early prediction of hERG K+ channel affinity of drug candidates is becoming increasingly important in the drug discovery process. Both structure-based and ligand-based approaches have been undertak Read More
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Calcium Sensing Receptor Activators: Calcimimetics
Authors: Paul E. Harrington and Christopher FotschThe calcium sensing receptor (CaR) is a G protein-coupled receptor (GPCR) that plays a fundamental role in serum calcium homeostasis. The CaR is expressed on the chief cells of the parathyroid gland and is responsible for controlling the secretion of parathyroid hormone (PTH). PTH acts on several organs including the bone, kidney, and intestine to tightly regulate the concentration of serum calcium. Substances other than c Read More
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Tamoxifen Resistance and Epigenetic Modifications in Breast Cancer Cell Lines
Authors: Eric Badia, Joan Oliva, Patrick Balaguer and Vincent CavaillesEpigenetic mechanisms play crucial roles in many processes, including neoplasia, genomic imprinting, gene silencing, differentiation, embryogenesis and X chromosome inactivation. Their relevance in human disease and therapy has grown rapidly with the recent emergence of drugs that target for example DNA methylation or histone acetylation. Epigenetic effects were also recently highlighted by the decipheri Read More
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Regulation of Mast Cell Development by Inflammatory Factors
Authors: Zhi-Qing Hu, Wei-Hua Zhao and Tadakatsu ShimamuraMast cells are potent effectors playing a key role in IgE-associated hypersensitivity reactions, allergic disorders, inflammation and protective immune responses. Mast cell development in vivo occurs mainly in non-hematopoietic microenvironments and increased mast cell numbers can be seen in various inflammatory diseases and pathologic conditions. SCF (also known as kit ligand or KitL) and c-kit signaling are essential f Read More
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Volumes & issues
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Volume 32 (2025)
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Volume 31 (2024)
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Volume 30 (2023)
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Volume 29 (2022)
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Volume 28 (2021)
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Volume 27 (2020)
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Volume 26 (2019)
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Volume 25 (2018)
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Volume 24 (2017)
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Volume 23 (2016)
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Volume 22 (2015)
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Volume 21 (2014)
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Volume 20 (2013)
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Volume 19 (2012)
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Volume 18 (2011)
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Volume 17 (2010)
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Volume 16 (2009)
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Volume 15 (2008)
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Volume 14 (2007)
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Volume 13 (2006)
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Volume 12 (2005)
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Volume 11 (2004)
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Volume 10 (2003)
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Volume 9 (2002)
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Volume 8 (2001)
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Volume 7 (2000)
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