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Volume 31, Issue 38
  • ISSN: 0929-8673
  • E-ISSN: 1875-533X

Abstract

Periodontitis is the most common inflammatory oral disease that affects around 15% of adults and contributes to severe periodontal tissue destruction with subsequent tooth loosening and loss. Among the main pathogenic mechanisms underlying periodontitis, excessive reactive oxygen species production and oxidative stress play a predominant role in inducing both local and systemic damage. Current therapeutic approaches have expanded the conventional methods combined with herbal antioxidant compounds to free radical-scavenging nanomaterials and infrared laser therapy, offering promising pre-clinical evidence in periodontitis management. Herein, we review the pathogenic mechanisms of reactive oxygen species tissue damage, along with recent advances in oxidative stress biomarkers and novel targeting options.

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2024-05-09
2024-11-19

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Advances of Oxidative Stress Impact in Periodontitis: Biomarkers and Effective Targeting Options
Curr. Med. Chem. 31, 6187 (2024); https://doi.org/10.2174/0109298673297545240507091410
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  • Article Type:     Review Article
Keyword(s): antioxidants; carotenoids; curcumin; Oxidative stress; periodontitis; reactive oxygen species; resveratrol

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