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Volume 32, Issue 10
  • ISSN: 0929-8673
  • E-ISSN: 1875-533X

Abstract

Background

The novel coronavirus pneumonia (COVID-19) outbreak in late 2019 killed millions worldwide. Coronaviruses cause diseases such as severe acute respiratory syndrome (SARS-CoV) and SARS-CoV-2. Many peptides in the host defense system have antiviral activity. How to establish a set of efficient models to identify anti-coronavirus peptides is a meaningful study.

Methods

Given this, a new prediction model EACVP is proposed. This model uses the evolutionary scale language model (ESM-2 LM) to characterize peptide sequence information. The ESM model is a natural language processing model trained by machine learning technology. It is trained on a highly diverse and dense dataset (UR50/D 2021_04) and uses the pre-trained language model to obtain peptide sequence features with 320 dimensions. Compared with traditional feature extraction methods, the information represented by ESM-2 LM is more comprehensive and stable. Then, the features are input into the convolutional neural network (CNN), and the convolutional block attention module (CBAM) lightweight attention module is used to perform attention operations on CNN in space dimension and channel dimension. To verify the rationality of the model structure, we performed ablation experiments on the benchmark and independent test datasets. We compared the EACVP with existing methods on the independent test dataset.

Results

Experimental results show that ACC, F1-score, and MCC are 3.95%, 35.65% and 0.0725 higher than the most advanced methods, respectively. At the same time, we tested EACVP on ENNAVIA-C and ENNAVIA-D data sets, and the results showed that EACVP has good migration and is a powerful tool for predicting anti-coronavirus peptides.

Conclusion

The results prove that this model EACVP could fully characterize the peptide information and achieve high prediction accuracy. It can be generalized to different data sets. The data and code of the article have been uploaded to https://github.com/JYY625/EACVP.git.

© 2025 Bentham Science Publishers
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2025-04-01

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/content/journals/cmc/10.2174/0109298673287899240303164403
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EACVP: An ESM-2 LM Framework Combined CNN and CBAM Attention to Predict Anti-coronavirus Peptides
Curr. Med. Chem. 32, 2040 (2025); https://doi.org/10.2174/0109298673287899240303164403
/content/journals/cmc/10.2174/0109298673287899240303164403
/content/journals/cmc/10.2174/0109298673287899240303164403
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  • Article Type:     Research Article
Keyword(s): Anti-coronavirus peptides; CBAM attention mechanism; CNN; Ebola virus; ESM-2 LM; papillomaviru

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