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Volume 32, Issue 10
  • ISSN: 0929-8673
  • E-ISSN: 1875-533X

Abstract

The natural polyphenol, calebin-A, was recently discovered and identified as a novel phytopharmaceutical with anti-inflammatory, anti-tumor, and antiproliferative properties. Calebin-A occurs naturally in trace quantities in , commonly known as turmeric, from the Zingiberaceae family. Calebin-A is a curcumin analog or 'chemical cousin' of curcumin with a similar chemical structure. Although few research studies have been conducted on the pharmacological and therapeutic properties of calebin-A, it is a very promising molecule with a variety of pharmacological properties. Some studies have suggested that calebin-A is helpful in treating various cancers due to its inhibitory effect on cell growth and anti-inflammatory properties. Other studies have suggested that calebin-A may improve neurocognitive status associated with neurodegeneration caused by Alzheimer’s disease (AD) by inhibiting the aggregation of β-amyloid. Finally, several studies have proposed that calebin-A may potentially be therapeutically beneficial in treating patients with obesity. This novel compound downregulates nuclear factor (NF)-κB-mediated processes involved with cancer, such as tumor cell invasion, proliferation, metastasis, and, most profoundly, inflammation. Moreover, calebin-A influences the activities of mitogen-activated protein kinases (MAPKs) in cancer cells. The present review identifies and discusses the pharmacological and phytochemical properties of calebin-A, as well as its therapeutic benefits and limitations, for future scientists and clinicians interested in exploring calebin-A’s medicinal qualities.

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2023-10-10
2025-04-01

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An Overview of the Pharmacological Properties of Calebin-A
Curr. Med. Chem. 32, 2005 (2025); https://doi.org/10.2174/0109298673245074230925153031
/content/journals/cmc/10.2174/0109298673245074230925153031
/content/journals/cmc/10.2174/0109298673245074230925153031
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  • Article Type:     Review Article
Keyword(s): Calebin-A; curcumin; pharmacology; phytochemical; Polyphenol; turmeric

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