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image of Acute Effect of Honey-sweetened Coffee on Blood Pressure, Heart Rate and Blood Glucose Level in Healthy Female Subjects

Abstract

Background

The consumption of coffee as a beverage and honey as a sweetener is prevalent worldwide, with each having potential health implications. However, studies on the combined effect of coffee and honey on blood pressure, heart rate, and blood glucose level are lacking.

Objective

The objective of this study is to determine whether a three-day consumption of honey-sweetened coffee will significantly alter the systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), and fasting blood glucose (BG) levels in young, healthy female adults.

Methods

Thirty participants studying at the University of Uyo, aged 18 to 26 years, were randomly assigned to three groups: control, coffee, and honey-sweetened coffee groups with 10 subjects each. The control group was given 250 mL of warm water, the coffee group was given 2.25 g of coffee dissolved in 250 mL of hot water, and the honey-sweetened coffee group was given 2.25 g of coffee with 20 mL of honey dissolved in 250 mL of hot water for three consecutive days. Before the start of the experiment, the subjects were asked to rest by sitting comfortably for 15 minutes. Baseline measurements of blood pressure, heart rate, and blood glucose were taken and recorded before the consumption of the assigned beverage. Follow-up measurements were taken at 15, 30, 45, and 60 minutes after consumption for blood pressure and heart rate and 30 and 60 minutes for blood glucose level. This procedure was repeated for three days.

Results

The results showed no significant changes in systolic blood pressure, diastolic blood pressure, mean arterial pressure, heart rate, and blood glucose level in the coffee and honey-sweetened coffee groups compared to the control group.

Conclusion

The findings of this study revealed that honey-sweetened coffee has no acute effect on blood pressure, heart rate, and blood glucose level in healthy female individuals. It can, therefore, be concluded that honey-sweetened coffee has a neutral effect on these physiological parameters, but a more elaborate study is highly recommended.

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2024-12-27
2025-01-19
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References

  1. Alfawaz H.A. Khan N. Yakout S.M. Khattak M.N.K. Alsaikhan A.A. Almousa A.A. Alsuwailem T.A. Almjlad T.M. Alamri N.A. Alshammari S.G. Al-Daghri N.M. Prevalence, predictors, and awareness of coffee consumption and its trend among saudi female students. Int. J. Environ. Res. Publ. Heal. 2020 17 19 7020 10.3390/ijerph17197020 32992846
    [Google Scholar]
  2. Sarno J.D.D. Sarno J.M.D. Caffeine consumption and its effects towards young adults’ short-ter memory recall. Int. J. New Econo. Soci. Sci. 2022 1 15 267 288
    [Google Scholar]
  3. Lone A. Alnawah A.K. Hadadi A.S. Alturkie F.M. Aldreweesh Y.A. Alhedhod A.T. Coffee consumption behavior in young adults: Exploring motivations, frequencies, and reporting adverse effects and withdrawal symptoms. Psychol. Res. Behav. Manag. 2023 16 3925 3937
    [Google Scholar]
  4. dePaula J. Farah A. Caffeine consumption through coffee: Content in the beverage, metabolism, health benefits and risks. Beverages 2019 5 2 37 10.3390/beverages5020037
    [Google Scholar]
  5. Barrea L. Pugliese G. Frias-Toral E. El Ghoch M. Castellucci B. Chapela S.P. Carignano M.A. Laudisio D. Savastano S. Colao A. Muscogiuri G. Coffee consumption, health benefits and side effects: A narrative review and update for dietitians and nutritionists. Crit. Rev. Food Sci. Nutr. 2023 63 9 1238 1261 10.1080/10408398.2021.1963207 34455881
    [Google Scholar]
  6. Patocka J. Navratilova Z. Krejcar O. Kuca K. Coffee, Caffeine and Cognition: A Benefit or Disadvantage? Lett. Drug Des. Discov. 2019 16 10 1146 1156 10.2174/1570180816666190620142158
    [Google Scholar]
  7. Riera-Sampol A. Rodas L. Martínez S. Moir H.J. Tauler P. Caffeine intake among undergraduate students: Sex differences, sources, motivations, and associations with smoking status and self-reported sleep quality. Nutrients 2022 14 8 1661 10.3390/nu14081661 35458223
    [Google Scholar]
  8. Parras P. Martíneztomé M. Jiménez A. Murcia M. Antioxidant capacity of coffees of several origins brewed following three different procedures. Food Chem. 2007 102 3 582 592 10.1016/j.foodchem.2006.05.037
    [Google Scholar]
  9. Mussatto S.I. Machado E.M.S. Martins S. Teixeira J.A. Production, composition, and application of coffee and its industrial residues. Food Bioprocess Technol. 2011 4 5 661 672 10.1007/s11947‑011‑0565‑z
    [Google Scholar]
  10. Vignoli J.A. Viegas M.C. Bassoli D.G. Benassi M.T. Roasting process affects differently the bioactive compounds and the antioxidant activity of arabica and robusta coffees. Food Res. Int. 2014 61 279 285 10.1016/j.foodres.2013.06.006
    [Google Scholar]
  11. Esquivel P. Jiménez V.M. Functional properties of coffee and coffee by-products. Food Res. Int. 2012 46 2 488 495 10.1016/j.foodres.2011.05.028
    [Google Scholar]
  12. Chambers D. Phan U. Chanadang S. Maughan C. Sanchez K. Di Donfrancesco B. Gomez D. Higa F. Li H. Chambers E. Esen E. Motivations for food consumption during specific eating occasions in turkey. Foods 2016 5 2 39 10.3390/foods5020039 28231134
    [Google Scholar]
  13. Samoggia A. Riedel B. Consumers’ perceptions of coffee health benefits and motives for coffee consumption and purchasing. Nutrients 2019 11 3 653 10.3390/nu11030653 30889887
    [Google Scholar]
  14. Pua A. Goh R.M.V. Huang Y. Tang V.C.Y. Ee K.H. Cornuz M. Liu S.Q. Lassabliere B. Yu B. Recent advances in analytical strategies for coffee volatile studies: Opportunities and challenges. Food Chem. 2022 388 132971 10.1016/j.foodchem.2022.132971 35462220
    [Google Scholar]
  15. Seninde D.R. Chambers E. IV Coffee flavor: A review. Beverages 2020 6 3 44 10.3390/beverages6030044
    [Google Scholar]
  16. Febrianto N.A. Zhu F. Coffee bean processing: Emerging methods and their effects on chemical, biological and sensory properties. Food Chem. 2023 412 135489 10.1016/j.foodchem.2023.135489 36716620
    [Google Scholar]
  17. Uman E. Colonna-Dashwood M. Colonna-Dashwood L. Perger M. Klatt C. Leighton S. Miller B. Butler K.T. Melot B.C. Speirs R.W. Hendon C.H. The effect of bean origin and temperature on grinding roasted coffee. Sci. Rep. 2016 6 1 24483 10.1038/srep24483 27086837
    [Google Scholar]
  18. Várady M. Tauchen J. Fraňková A. Klouček P. Popelka P. Effect of method of processing specialty coffee beans (natural, washed, honey, fermentation, maceration) on bioactive and volatile compounds. Lebensm. Wiss. Technol. 2022 172 114245 10.1016/j.lwt.2022.114245
    [Google Scholar]
  19. Spiller M.A. The chemical components of coffee. Caffeine. Spiller G.A. CRC Press; Boca Raton NewYork, NY, USA 1998 97 161
    [Google Scholar]
  20. Saud S. Salamatullah A.M. Relationship between the chemical composition and the biological functions of coffee. Molecules 2021 26 24 7634 10.3390/molecules26247634 34946716
    [Google Scholar]
  21. Chaugule A. Patil H. Pagariya S. Ingle P. Extraction of caffeine. Int. J. Adv. Res. Chem. Sci. 2019 6 9 11 19
    [Google Scholar]
  22. Evans J. Richards J.R. Battisti A.S. Caffeine. StatPearls. Treasure Island, FL StatPearls Publishing 2024 30137774
    [Google Scholar]
  23. Daly J.W. Shi D. Nikodijevic O. Jacobson K.A. The role of adenosine receptors in the central action of caffeine. Pharmacopsychoecologia 1994 7 2 201 213 25821357
    [Google Scholar]
  24. Ribeiro J.A. Sebastião A.M. Caffeine and adenosine. J. Alzheimers Dis. 2010 20 s1 Suppl. 1 S3 S15 10.3233/JAD‑2010‑1379 20164566
    [Google Scholar]
  25. Aguiar A.S. Jr Speck A.E. Canas P.M. Cunha R.A. Neuronal adenosine A2A receptors signal ergogenic effects of caffeine. Sci. Rep. 2020 10 1 13414 10.1038/s41598‑020‑69660‑1 32770138
    [Google Scholar]
  26. Yeager S.E. Batali M.E. Guinard J.X. Ristenpart W.D. Acids in coffee: A review of sensory measurements and meta-analysis of chemical composition. Crit. Rev. Food Sci. Nutr. 2023 63 8 1010 1036 10.1080/10408398.2021.1957767 34553656
    [Google Scholar]
  27. Rune C. J. B. Giacalone D. Steen I. Duelund L. Münchow M. Clausen M. P. Acids in brewed coffees: Chemical composition and sensory threshold. Curr. Res. Food Sci. 2023 6 100485 10.1016/j.crfs.2023.100485 37033739
    [Google Scholar]
  28. Oosterveld A. Voragen A.G.J. Schols H.A. Effect of roasting on the carbohydrate composition of Coffea arabica beans. Carbohydr. Polym. 2003 54 2 183 192 10.1016/S0144‑8617(03)00164‑4
    [Google Scholar]
  29. Arya M. Rao L.J.M. An impression of coffee carbohydrates. Crit. Rev. Food Sci. Nutr. 2007 47 1 51 67 10.1080/10408390600550315 17364695
    [Google Scholar]
  30. Portillo O.R. Arévalo A.C. Coffee’s carbohydrates. A critical review of scientific literature. Bionatura 2022 7 3 1 12 10.21931/RB/2022.07.03.11
    [Google Scholar]
  31. Angeloni S. Mustafa A.M. Abouelenein D. Alessandroni L. Acquaticci L. Nzekoue F.K. Petrelli R. Sagratini G. Vittori S. Torregiani E. Caprioli G. Characterization of the Aroma Profile and Main Key Odorants of Espresso Coffee. Molecules 2021 26 13 3856 10.3390/molecules26133856 34202706
    [Google Scholar]
  32. Wang X. Wang Y. Hu G. Hong D. Guo T. Li J. Li Z. Qiu M. Review on factors affecting coffee volatiles: From seed to cup. J. Sci. Food Agric. 2022 102 4 1341 1352 10.1002/jsfa.11647 34778973
    [Google Scholar]
  33. Janda K. Jakubczyk K. Baranowska-Bosiacka I. Kapczuk P. Kochman J. Rębacz-Maron E. Gutowska I. Mineral composition and antioxidant potential of coffee beverages depending on the brewing method. Foods 2020 9 2 121 10.3390/foods9020121 31979386
    [Google Scholar]
  34. Gillies M.E. Birkbeck J.A. Tea and coffee as sources of some minerals in the New Zealand diet. Am. J. Clin. Nutr. 1983 38 6 936 942 10.1093/ajcn/38.6.936 6650450
    [Google Scholar]
  35. Zuhair Mohd Zain M. Shori A.B. Baba A.S. Composition and health properties of coffee bean. Euro. J. Clini. Biomedi. Sci. 2017 3 5 97 100 10.11648/j.ejcbs.20170305.13
    [Google Scholar]
  36. Olechno E. Puścion-Jakubik A. Socha K. Zujko M.E. Coffee brews: Are they a source of macroelements in human nutrition? Foods 2021 10 6 1328 10.3390/foods10061328 34207680
    [Google Scholar]
  37. Cory H. Passarelli S. Szeto J. Tamez M. Mattei J. The role of polyphenols in human health and food systems: A mini-review. Front. Nutr. 2018 5 87 10.3389/fnut.2018.00087 30298133
    [Google Scholar]
  38. Rudrapal M. Khairnar S.J. Khan J. Dukhyil A.B. Ansari M.A. Alomary M.N. Alshabrmi F.M. Palai S. Deb P.K. Devi R. Dietary polyphenols and their role in oxidative stress-induced human diseases: Insights into protective effects, antioxidant potentials and mechanism(s) of action. Front. Pharmacol. 2022 13 806470 10.3389/fphar.2022.806470 35237163
    [Google Scholar]
  39. LIczbiński P. Bukowska B. Tea and coffee polyphenols and their biological properties based on the latest in vitro investigations. Ind. Crops Prod. 2022 175 114265 10.1016/j.indcrop.2021.114265 34815622
    [Google Scholar]
  40. Makiso M.U. Tola Y.B. Ogah O. Endale F.L. Bioactive compounds in coffee and their role in lowering the risk of major public health consequences: A review. Food Sci. Nutr. 2024 12 2 734 764 10.1002/fsn3.3848 38370073
    [Google Scholar]
  41. Zakidou P. Plati F. Matsakidou A. Varka E.M. Blekas G. Paraskevopoulou A. Single origin coffee aroma: From optimized flavor protocols and coffee customization to instrumental volatile characterization and chemometrics. Molecules 2021 26 15 4609 10.3390/molecules26154609 34361765
    [Google Scholar]
  42. Pham M.C. Dinh N.Y. Phu H.L. Coffee volatile compounds. Int. J. Food Sci. Nutr. 2023 8 3 50 57
    [Google Scholar]
  43. Butt M.S. Sultan M.T. Coffee and its consumption: Benefits and risks. Crit. Rev. Food Sci. Nutr. 2011 51 4 363 373 10.1080/10408390903586412 21432699
    [Google Scholar]
  44. Bidel S. Tuomilehto J. The emerging health benefits of coffee with an emphasis on type 2 diabetes and cardiovascular disease. Eur. Endocrinol. 2013 9 2 99 106 29922362
    [Google Scholar]
  45. Poole R. Kennedy O.J. Roderick P. Fallowfield J.A. Hayes P.C. Parkes J. Coffee consumption and health: Umbrella review of meta-analyses of multiple health outcomes. BMJ 2017 359 j5024 10.1136/bmj.j5024 29167102
    [Google Scholar]
  46. Safe S. Kothari J. Hailemariam A. Upadhyay S. Davidson L.A. Chapkin R.S. Health benefits of coffee consumption for cancer and other diseases and mechanisms of action. Int. J. Mol. Sci. 2023 24 3 2706 10.3390/ijms24032706 36769029
    [Google Scholar]
  47. Yu X. Bao Z. Zou J. Dong J. Coffee consumption and risk of cancers: A meta-analysis of cohort studies. BMC Cancer 2011 11 1 96 10.1186/1471‑2407‑11‑96 21406107
    [Google Scholar]
  48. Saab S. Mallam D. Cox G.A. II Tong M.J. Impact of coffee on liver diseases: A systematic review. Liver Int. 2014 34 4 495 504 10.1111/liv.12304 24102757
    [Google Scholar]
  49. Tamura T. Hishida A. Wakai K. Coffee consumption and liver cancer risk in Japan: A meta-analysis of six prospective cohort studies. Nagoya J. Med. Sci. 2019 81 1 143 150 30962663
    [Google Scholar]
  50. Ruxton C.H.S. The impact of caffeine on mood, cognitive function, performance and hydration: A review of benefits and risks. Nutr. Bull. 2008 33 1 15 25 10.1111/j.1467‑3010.2007.00665.x
    [Google Scholar]
  51. Lazarus M. Shen H.Y. Cherasse Y. Qu W.M. Huang Z.L. Bass C.E. Winsky-Sommerer R. Semba K. Fredholm B.B. Boison D. Hayaishi O. Urade Y. Chen J.F. Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens. J. Neurosci. 2011 31 27 10067 10075 10.1523/JNEUROSCI.6730‑10.2011 21734299
    [Google Scholar]
  52. Fiani B. Zhu L. Musch B.L. Briceno S. Andel R. Sadeq N. Ansari A.Z. The neurophysiology of caffeine as a central nervous system stimulant and the resultant effects on cognitive function. Cureus 2021 13 5 e15032 10.7759/cureus.15032 34150383
    [Google Scholar]
  53. Santos C. Costa J. Santos J. Vaz-Carneiro A. Lunet N. Caffeine intake and dementia: Systematic review and meta-analysis. J. Alzheimers Dis. 2010 20 s1 Suppl. 1 S187 S204 10.3233/JAD‑2010‑091387 20182026
    [Google Scholar]
  54. Camfield D.A. Stough C. Farrimond J. Scholey A.B. Acute effects of tea constituents L-theanine, caffeine, and epigallocatechin gallate on cognitive function and mood: A systematic review and meta-analysis. Nutr. Rev. 2014 72 8 507 522 10.1111/nure.12120 24946991
    [Google Scholar]
  55. Wood S. Sage J.R. Shuman T. Anagnostaras S.G. Psychostimulants and cognition: A continuum of behavioral and cognitive activation. Pharmacol. Rev. 2014 66 1 193 221 10.1124/pr.112.007054 24344115
    [Google Scholar]
  56. Graham T.E. Caffeine and exercise. Sports Med. 2001 31 11 785 807 10.2165/00007256‑200131110‑00002 11583104
    [Google Scholar]
  57. Guest N.S. VanDusseldorp T.A. Nelson M.T. Grgic J. Schoenfeld B.J. Jenkins N.D.M. Arent S.M. Antonio J. Stout J.R. Trexler E.T. Smith-Ryan A.E. Goldstein E.R. Kalman D.S. Campbell B.I. International society of sports nutrition position stand: Caffeine and exercise performance. J. Int. Soc. Sports Nutr. 2021 18 1 1 10.1186/s12970‑020‑00383‑4 33388079
    [Google Scholar]
  58. Nehlig A. Daval J.L. Debry G. Caffeine and the central nervous system: Mechanisms of action, biochemical, metabolic and psychostimulant effects. Brain Res. Brain Res. Rev. 1992 17 2 139 170 10.1016/0165‑0173(92)90012‑B 1356551
    [Google Scholar]
  59. Reddy V.S. Shiva S. Manikantan S. Ramakrishna S. Pharmacology of caffeine and its effects on the human body. Europ. J. Med. Chem. Rep. 2024 10 100138 10.1016/j.ejmcr.2024.100138
    [Google Scholar]
  60. Wang L. Shen X. Wu Y. Zhang D. Coffee and caffeine consumption and depression: A meta-analysis of observational studies. Aust. N. Z. J. Psychiatry 2016 50 3 228 242 10.1177/0004867415603131 26339067
    [Google Scholar]
  61. Grosso G. Micek A. Castellano S. Pajak A. Galvano F. Coffee, tea, caffeine and risk of depression: A systematic review and dose–response meta‐analysis of observational studies. Mol. Nutr. Food Res. 2016 60 1 223 234 10.1002/mnfr.201500620 26518745
    [Google Scholar]
  62. Lucas M. Mirzaei F. Pan A. Okereke O.I. Willett W.C. O’Reilly É.J. Koenen K. Ascherio A. Coffee, caffeine, and risk of depression among women. Arch. Intern. Med. 2011 171 17 1571 1578 10.1001/archinternmed.2011.393 21949167
    [Google Scholar]
  63. Farah A. de Paula Lima J. Consumption of chlorogenic acids through coffee and health implications. Beverages 2019 5 1 11 10.3390/beverages5010011
    [Google Scholar]
  64. Mohamed A.I. Erukainure O.L. Salau V.F. Islam M.S. Impact of coffee and its bioactive compounds on the risks of type 2 diabetes and its complications: A comprehensive review. Diabetes Metab. Syndr. 2024 18 7 103075 10.1016/j.dsx.2024.103075 39067326
    [Google Scholar]
  65. Schubert M.M. Irwin C. Seay R.F. Clarke H.E. Allegro D. Desbrow B. Caffeine, coffee, and appetite control: A review. Int. J. Food Sci. Nutr. 2017 68 8 901 912 10.1080/09637486.2017.1320537 28446037
    [Google Scholar]
  66. Tabrizi R. Saneei P. Lankarani K.B. Akbari M. Kolahdooz F. Esmaillzadeh A. Nadi-Ravandi S. Mazoochi M. Asemi Z. The effects of caffeine intake on weight loss: A systematic review and dos-response meta-analysis of randomized controlled trials. Crit. Rev. Food Sci. Nutr. 2019 59 16 2688 2696 10.1080/10408398.2018.1507996 30335479
    [Google Scholar]
  67. Shang F. Li X. Jiang X. Coffee consumption and risk of the metabolic syndrome: A meta-analysis. Diabetes Metab. 2016 42 2 80 87 10.1016/j.diabet.2015.09.001 26431818
    [Google Scholar]
  68. Corbi-Cobo-Losey M.J. Martinez-Gonzalez M.Á. Gribble A.K. Fernandez-Montero A. Navarro A.M. Domínguez L.J. Bes-Rastrollo M. Toledo E. Coffee consumption and the risk of metabolic syndrome in the ‘seguimiento universidad de navarra’ project. Antioxidants 2023 12 3 686 10.3390/antiox12030686 36978934
    [Google Scholar]
  69. Alshahrani S.H. Atia Y.A. Badir R.A. Almalki S.G. Tayyib N.A. Shahab S. Romero-Parra R.M. Abid M.K. Hussien B.M. Ramaiah P. Dietary caffeine intake is associated with favorable metabolic profile among apparently healthy overweight and obese individuals. BMC Endocr. Disord. 2023 23 1 227 10.1186/s12902‑023‑01477‑1 37864190
    [Google Scholar]
  70. Rodak K. Kokot I. Kratz E.M. Caffeine as a factor influencing the functioning of the human body—friend or foe? Nutrients 2021 13 9 3088 10.3390/nu13093088 34578966
    [Google Scholar]
  71. Jee S. H. He J. Whelton P. K. Suh I. Klag M. J. The effect of chronic coffee drinking on blood pressure: A meta-analysis of controlled clinical trials. Hypertension. 1999 33 2 647 652 10.1161/01.HYP.33.2.647 10024321
    [Google Scholar]
  72. Nurminen M-L. Niittynen L. Korpela R. Vapaatalo H. Coffee, caffeine and blood pressure: A critical review. Eur. J. Clin. Nutr. 1999 53 11 831 839 10.1038/sj.ejcn.1600899 10556993
    [Google Scholar]
  73. Abbas-Hashemi S.A. Hosseininasab D. Rastgoo S. Shiraseb F. Asbaghi O. The effects of caffeine supplementation on blood pressure in adults: A systematic review and dose-response meta-analysis. Clin. Nutr. ESPEN 2023 58 165 177 10.1016/j.clnesp.2023.09.923 38057002
    [Google Scholar]
  74. Mesas A.E. Leon-Muñoz L.M. Rodriguez-Artalejo F. Lopez-Garcia E. The effect of coffee on blood pressure and cardiovascular disease in hypertensive individuals: A systematic review and meta-analysis. Am. J. Clin. Nutr. 2011 94 4 1113 1126 10.3945/ajcn.111.016667 21880846
    [Google Scholar]
  75. Hartley T. R. Sung B. H. Pincomb G. A. Whitsett T. L. Wilson M. F. Lovallo W. R. Hypertension risk status and effect of caffeine on blood pressure. Hypertension. 2000 36 1 137 141 10.1161/01.HYP.36.1.137 10904026
    [Google Scholar]
  76. Tuasikal M.I. Felani M.R. Fathoni M.Y. Sabara S.M.A. 74. The effect of caffeinated coffee on blood pressure: A systematic review. J. Hypertens. 2021 39 Suppl. 2 e19 e20 10.1097/01.hjh.0000752644.80309.6e
    [Google Scholar]
  77. Papadelis C. Kourtidou-Papadeli C. Vlachogiannis E. Skepastianos P. Bamidis P. Maglaveras N. Pappas K. Effects of mental workload and caffeine on catecholamines and blood pressure compared to performance variations. Brain Cogn. 2003 51 1 143 154 10.1016/S0278‑2626(02)00530‑4 12633594
    [Google Scholar]
  78. Barcelos R.P. Lima F.D. Carvalho N.R. Bresciani G. Royes L.F.F. Caffeine effects on systemic metabolism, oxidative-inflammatory pathways, and exercise performance. Nutr. Res. 2020 80 1 17 10.1016/j.nutres.2020.05.005 32589582
    [Google Scholar]
  79. Zhang Y. Coca A. Casa D.J. Antonio J. Green J.M. Bishop P.A. Caffeine and diuresis during rest and exercise: A meta-analysis. J. Sci. Med. Sport 2015 18 5 569 574 10.1016/j.jsams.2014.07.017 25154702
    [Google Scholar]
  80. Marx B. Scuvée É. Scuvée-Moreau J. Seutin V. Jouret F. Mechanisms of caffeine-induced diuresis. Med. Sci. 2016 32 5 485 490 10.1051/medsci/20163205015 27225921
    [Google Scholar]
  81. Borghi C. Coffee and blood pressure: Exciting news! Blood Press. 2022 31 1 284 287 10.1080/08037051.2022.2136621 36316990
    [Google Scholar]
  82. Kujawska A. Kujawski S. Hajec W. Skierkowska N. Kwiatkowska M. Husejko J. Newton J.L. Simoes J.A. Zalewski P. Kędziora-Kornatowska K. Coffee Consumption and blood pressure: Results of the second wave of the cognition of older people, education, recreational activities, nutrition, comorbidities, and functional capacity studies (Copernicus). Nutrients 2021 13 10 3372 10.3390/nu13103372 34684373
    [Google Scholar]
  83. Tandiono E.J. Budiyanti E. The effect of coffee consumption on acute increased blood pressure in normotensive teens. J. Urb. Heal. Res. 2023 1 2 79 84 10.25170/juhr.v1i2.4297
    [Google Scholar]
  84. Cicero A.F.G. Fogacci F. D’Addato S. Grandi E. Rizzoli E. Borghi C. Self-reported coffee consumption and central and peripheral blood pressure in the cohort of the brisighella heart study. Nutrients 2023 15 2 312 10.3390/nu15020312 36678184
    [Google Scholar]
  85. Lima de Castro F.B.A. Castro F.G. da Cunha M.R. Pacheco S. Freitas-Silva O. Neves M.F. Klein M.R.S.T. Acute effects of coffee consumption on blood pressure and endothelial function in individuals with hypertension on antihypertensive drug treatment: A randomized crossover trial. High Blood Press. Cardiovasc. Prev. 2024 31 1 65 76 10.1007/s40292‑024‑00622‑8 38308805
    [Google Scholar]
  86. Nurvita S. Rizkaprilisa W. Coffee and blood pressure. Coff. Sci. 2024 19 e192193
    [Google Scholar]
  87. Pizziol A. Tikhonoff V. Paleari C.D. Russo E. Mazza A. Ginocchio G. Onesto C. Pavan L. Casiglia E. Pessina A.C. Effects of caffeine on glucose tolerance: A placebo-controlled study. Eur. J. Clin. Nutr. 1998 52 11 846 849 10.1038/sj.ejcn.1600657 9846599
    [Google Scholar]
  88. Greer F. Hudson R. Ross R. Graham T. Caffeine ingestion decreases glucose disposal during a hyperinsulinemic-euglycemic clamp in sedentary humans. Diabetes 2001 50 10 2349 2354 10.2337/diabetes.50.10.2349 11574419
    [Google Scholar]
  89. Keijzers G.B. De Galan B.E. Tack C.J. Smits P. Caffeine can decrease insulin sensitivity in humans. Diabetes Care 2002 25 2 364 369 10.2337/diacare.25.2.364 11815511
    [Google Scholar]
  90. van Dam R.M. Feskens E.J.M. Coffee consumption and risk of type 2 diabetes mellitus. Lancet 2002 360 9344 1477 1478 10.1016/S0140‑6736(02)11436‑X 12433517
    [Google Scholar]
  91. Arnlöv J. Vessby B. Risérus U. Coffee consumption and insulin sensitivity. JAMA 2004 291 10 1199-a 1201 10.1001/jama.291.10.1199‑b 15010440
    [Google Scholar]
  92. Rosengren A. Dotevall A. Wilhelmsen L. Thelle D. Johansson S. Coffee and incidence of diabetes in Swedish women: A prospective 18‐year follow‐up study. J. Intern. Med. 2004 255 1 89 95 10.1046/j.1365‑2796.2003.01260.x 14687243
    [Google Scholar]
  93. Ding P. Yue W. Wang X. Zhang Y. Liu Y. Guo X. Effects of sugary drinks, coffee, tea and fruit juice on incidence rate, mortality and cardiovascular complications of type2 diabetes patients: A systematic review and meta-analysis. J. Diabetes Metab. Disord. 2024 23 1 1113 1123 10.1007/s40200‑024‑01396‑5 38932853
    [Google Scholar]
  94. Rezaei Tavirani M. Farahani M. Rezaei Tavirani M. Razzaghi Z. Arjmand B. Khodadoost M. Introducing coffee as a complementary agent beside metformin against type 2 diabetes. Res. J. Pharmacog. 2024 11 3 31 40
    [Google Scholar]
  95. Cucu A.A. Baci G.M. Moise A.R. Dezsi Ş. Marc B.D. Stângaciu Ş. Dezmirean D.S. Towards a better understanding of nutritional and therapeutic effects of honey and their applications in apitherapy. Appl. Sci. 2021 11 9 4190 10.3390/app11094190
    [Google Scholar]
  96. Otero M.C.B. Bernolo L. Honey as Functional Food and Prospects in Natural Honey Production. Functional Foods and Nutraceuticals. Egbuna C. Dable Tupas G. Cham Springer 2020 10.1007/978‑3‑030‑42319‑3_11
    [Google Scholar]
  97. Adgaba N. Al-Ghamdi A. Tadesse Y. Getachew A. Awad A.M. Ansari M.J. Owayss A.A. Mohammed S.E.A. Alqarni A.S. Nectar secretion dynamics and honey production potentials of some major honey plants in Saudi Arabia. Saudi J. Biol. Sci. 2017 24 1 180 191 10.1016/j.sjbs.2016.05.002 28053589
    [Google Scholar]
  98. Hoover S.E. Ovinge L.P. Pollen collection, honey production, and pollination services: Managing honey bees in an agricultural setting. J. Econ. Entomol. 2018 111 4 1509 1516 10.1093/jee/toy125 29746645
    [Google Scholar]
  99. da Silva P.M. Gauche C. Gonzaga L.V. Costa A.C.O. Fett R. Honey: Chemical composition, stability and authenticity. Food Chem. 2016 196 309 323 10.1016/j.foodchem.2015.09.051 26593496
    [Google Scholar]
  100. Khan S.U. Anjum S.I. Rahman K. Ansari M.J. Khan W.U. Kamal S. Khattak B. Muhammad A. Khan H.U. Honey: Single food stuff comprises many drugs. Saudi J. Biol. Sci. 2018 25 2 320 325 10.1016/j.sjbs.2017.08.004 29472785
    [Google Scholar]
  101. Gündoğdu E. Çakmakçı S. Şat İ.G. An overview of honey: Its composition, nutritional and functional properties. J. Food Sci. Eng. 2019 9 10 14
    [Google Scholar]
  102. Khalil M.L. Sulaiman S.A. The potential role of honey and its polyphenols in preventing heart disease: A review. Afr. J. Tradit. Complement. Altern. Med. 2010 7 4 315 321 10.4314/ajtcam.v7i4.56693 21731163
    [Google Scholar]
  103. Mandal M.D. Mandal S. Honey: Its medicinal property and antibacterial activity. Asian Pac. J. Trop. Biomed. 2011 1 2 154 160 10.1016/S2221‑1691(11)60016‑6 23569748
    [Google Scholar]
  104. Simon A. Traynor K. Santos K. Blaser G. Bode U. Molan P. Medical honey for wound care--still the ‘latest resort’? Evid. Based Complement. Alternat. Med. 2009 6 2 165 173 10.1093/ecam/nem175 18955301
    [Google Scholar]
  105. Yaghoobi R. Kazerouni A. kazerouni O. Evidence for clinical use of honey in wound healing as an anti-bacterial, anti-inflammatory anti-oxidant and anti-viral agent: A review. Jundishapur J. Nat. Pharm. Prod. 2013 8 3 100 104 10.17795/jjnpp‑9487 24624197
    [Google Scholar]
  106. Samarghandian S. Farkhondeh T. Samini F. Honey and health: A review of recent clinical research. Pharmacognosy Res. 2017 9 2 121 127 28539734
    [Google Scholar]
  107. Olusola A. Olubobokun T.H. Bassey I.E. Atang D.E. Comparative study of effect of honey on blood pressure and heart rate in healthy male and female subjects. Br. J. Med. Med. Res. 2013 3 4 2214 2221 10.9734/BJMMR/2013/4152
    [Google Scholar]
  108. Rasad H. Dashtabi A. Khansari M. Chaboksavar F. Pahlavani N. Maghsoudi Z. Entezari M.H. The effect of honey consumption compared with sucrose on blood pressure and fasting blood glucose in healthy young subjects. J. Med. Food 2014 4 117 121
    [Google Scholar]
  109. Zhang S. Lu Z. Tian C. Zhang Q. Liu L. Meng G. Yao Z. Wu H. Xia Y. Bao X. Gu Y. Sun S. Wang X. Zhou M. Jia Q. Sun Z. Song K. Niu K. Associations between honey consumption and prehypertension in adults aged 40 years and older. Clin. Exp. Hypertens. 2020 42 5 420 427 10.1080/10641963.2019.1693584 31760826
    [Google Scholar]
  110. Hashim K.N. Chin K.Y. Ahmad F. The mechanism of honey in reversing metabolic syndrome. Molecules 2021 26 4 808 10.3390/molecules26040808 33557218
    [Google Scholar]
  111. Kumar R. Kumar S. Kanwar S.S. Pharmacological Properties of Honey. Biomedical Perspectives of Herbal Honey. Singapore Springer 2024 10.1007/978‑981‑97‑1529‑9_2
    [Google Scholar]
  112. Al-Waili N. Natural honey lowers plasma glucose, C-reactive protein, homocysteine, and blood lipids in healthy, diabetic, and hyperlipidemic subjects: Comparison with dextrose and sucrose. J. Med. Food 2011 14 1001 1009 15117561
    [Google Scholar]
  113. Abdulrhman M. El Hefnawy M. Ali R. Abdel Hamid I. Abou El-Goud A. Refai D. Effects of honey, sucrose and glucose on blood glucose and C-peptide in patients with type 1 diabetes mellitus. Complement. Ther. Clin. Pract. 2013 19 1 15 19 10.1016/j.ctcp.2012.08.002 23337559
    [Google Scholar]
  114. Majid M. Younis M.A. Naveed A.K. Shah M.U. Azeem Z. Tirmizi S.H. Effects of natural honey on blood glucose and lipid profile in young healthy Pakistani males. J. Ayub Med. Coll. Abbottabad 2013 25 3-4 44 47 25226738
    [Google Scholar]
  115. Bobiş O. Dezmirean D.S. Moise A.R. Honey and diabetes: The importance of natural simple sugars in diet for preventing and treating different type of diabetes. Oxid. Med. Cell. Longev. 2018 2018 1 4757893 10.1155/2018/4757893 29507651
    [Google Scholar]
  116. El-Aarag B. Shehata S.B. El-Garawani I.M. El-Seedi H.R. Nofal A.E. Regulation of oxidative stress and apoptosis in streptozotocin‐induced diabetic rats by egyptian sidr honey. Chem. Biodivers. 2024 21 7 e202400351 10.1002/cbdv.202400351 38717108
    [Google Scholar]
  117. Jamwal N. Jasrotia R. Badyal N. Hajam Y.A. Langer S. Honey: An Antidiabetic and Hypoglycemic Agent to Reverse Diabetes-Induced Complications. Honey in Food Science and Physiology. Kumar R. Hajam Y.A. Bala Dhull S. Giri A. Singapore Springer 2024 10.1007/978‑981‑97‑3565‑5_16
    [Google Scholar]
  118. Charan J. Biswas T. How to calculate sample size for different study designs in medical research? Indian J. Psychol. Med. 2013 35 2 121 126 10.4103/0253‑7176.116232 24049221
    [Google Scholar]
  119. Green P. J. Kirby R. Suls J. The effects of caffeine on blood pressure and heart rate: A review. Ann. Behav. Med. 1996 18 3 201 216 10.1007/BF02883398 24203773
    [Google Scholar]
  120. Hara A. Ohide H. Miyagawa K. Takeuchi T. Nakatani Y. Yokoyama H. Amano T. Acute effects of caffeine on blood pressure and heart rate in habitual and non-habitual coffee consumers. Japan. J. Pharmac. Heal. Care. Sci. 2014 40 7 383 388 10.5649/jjphcs.40.383
    [Google Scholar]
  121. Geleijnse M. Habitual coffee consumption and blood pressure: An epidemiological perspective. Vasc. Health Risk Manag. 2008 4 5 963 970 10.2147/VHRM.S3055 19183744
    [Google Scholar]
  122. Claudio B. Bragagni A. New evidence on coffee consumption, hypertension and cardiovascular diseases. G. Ital. Cardiol. 2022 23 5 323 327 10.1714/3796.37814 35578955
    [Google Scholar]
  123. Katarzyna B. Wojciech S. Marta P. Filip S. Daria W. Monika R. Sergiusz N. The effect of coffee on blood pressure at healthy subjects. Pol. Merkur. Lekarski. 2013 35 207 133 135 24224448
    [Google Scholar]
  124. K Alhabeeb M. M Alazzmi M. S Alrashidi M. Al-Sowayan N.S. Effect of caffeinated and decaffeinated coffee on blood pressure and heart rate of healthy individuals. Pak. J. Biol. Sci. 2022 25 4 337 344 10.3923/pjbs.2022.337.344 35638528
    [Google Scholar]
  125. Reis C.E.G. Dórea J.G. da Costa T.H.M. Effects of coffee consumption on glucose metabolism: A systematic review of clinical trials. J. Tradit. Complement. Med. 2019 9 3 184 191 10.1016/j.jtcme.2018.01.001 31193893
    [Google Scholar]
  126. Shailendra S.B. Archana K. Role of honey as a dietary adjunct for improvements of glycemic status and body weight in healthy individuals. Int. J. Contemp. Medi. Res. 2019 6 7
    [Google Scholar]
  127. Abdullah M. J. Intisar A. Wisam E. Zainab A. Ithar M. Marwa M. Ahmed S. Glycemic response to three different types of locally produced natural honey compared with dextrose and ordinary table sugar in apparently healthy volunteers. The Medi. J. Basr. Univer. 2008 26 2 69 75 10.33762/mjbu.2008.48372
    [Google Scholar]
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  • Article Type:
    Research Article
Keywords: diastolic blood pressure ; systolic blood pressure ; Coffee ; blood glucose ; heart rate ; honey
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