Current Genomics - Volume 6, Issue 2, 2005

The recent completion of the draft of the chicken genome sequence, the first for an agriculturally important animal species, confirms the utility of this extensively-studied and most understood avian species, as well as the utility of other little-studied birds in vertebrate biology and human medicine. The emerging information from the chicken genome is expected to increase our understanding of phenomena important in h Read More

To date, many genetic changes have been described and reported in the cancer process. Since the first mutations were described, several attempts to establish genotype-phenotype correlations for these genetic alterations have been reported. Moreover, in vitro data have suggested effects of mutant proteins in proliferation. Genotype-phenotype correlations are not only important for predicting the clinical course of t Read More

There are three methods for making chronic myelogenous leukemia (CML) mouse models: xenotransplantation of primary Ph-positive CML cells into immunodeficient mice, BCR/ABL-expressing transgenic mice, and BCR/ABL retroviral bone marrow transduction and transplantation. These animal models have provided us with important new insights into the molecular pathophysiology of CML and answered directly many qu Read More

The ability to interrogate gene expression levels of an organism's entire transcriptome has provided researchers with a powerful tool. This power has been brought to bear on biological questions in the areas of development, aging, cell biology, disease models, stress and toxicology. Many novel insights into biological processes have been obtained from these studies and have led to connections to other systems level approaches Read More

Multilocus HLA haplotypes could be investigated by family analysis, and there are salient differences in the distributions of HLA alleles among different populations. In the present study, HLA -A, B and DRB1 alleles and haplotypes were investigated based on 166 families in Shanghai Han population by molecular biological HLA typing methods and the distribution characteristic of HLA alleles and haplotypes were analyzed. Read More

It is well recognized that most medications exhibit wide interindividual variability in their efficacy and toxicity. These differences may be due to genetic factors affecting the metabolism and action of these drugs, as well as to environmental factors. Genetic polymorphisms (SNPs and haplotypes) that may play a role in the differences in response to lipid lowering therapy have recently been identified, including genetic Read More