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image of Consanguine Marriage Leads to Hierarchical Imbalance of ABO and STR Frequency and Affects the Genetic Diversity

Abstract

Consanguinity marriages pose a serious social issue for civil society, leading to genetic syndromes, depression, and imbalanced ABO blood types and STR frequencies. Analyzing dermatoglyphics in regions with prevalent consanguineous marriages can establish a correlation with ABO frequency. Consanguineous marriages complicate forensic DNA analysis due to reduced genetic diversity. Inbreeding within a closed, small population tends to accelerate the loss of genetic diversity and decrease the heterozygosity of genes, ultimately leading to complete homozygosity, fixation of rare alleles, and potential misidentification in inbred populations. Forensic investigations require careful consideration of population structure. Short Tandem Repeat (STR) profiling is effective but should be complemented with population-specific databases, additional genetic markers, and advanced statistical methods to address the effects of inbreeding. Understanding the genetic nuances in inbred populations can enhance the accuracy and reliability of DNA profiling.

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2025-01-14
2025-06-21

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Consanguine Marriage Leads to Hierarchical Imbalance of ABO and STR Frequency and Affects the Genetic Diversity
Bentham Science Publishers ; https://doi.org/10.2174/0126664844350819241231050738
/content/journals/cfs/10.2174/0126664844350819241231050738
/content/journals/cfs/10.2174/0126664844350819241231050738
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  • Article Type:     Review Article
Keywords: short tandem repeat (STR) ; consanguine ; consanguinity marriages ; ABO group ; Inbreeding ; DNA

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