Current Enzyme Inhibition - Volume 8, Issue 1, 2012

Welcome to the edition of the 8th Volume, number 1 of the Journal of Current Enzyme Inhibition. This issue includes four interesting reviews. Two of them are focused on natural products and on their role in cancer and cytotoxicity, one deals with a web based program to understand the essential structural features for a specific biological activity and the fourth presents iminoalditols targeting Carbohydrate processing enzymes. Bei Read More

Anthocyans (ACNs), i.e. anthocyanins and anthocyanidins, belong to a widespread group of plant constituents, collectively known as flavonoids, which occur in the western diet at relatively high concentrations. ACNs display a variety of pharmacological properties which make them potential anti-inflammatory and anti-cancer agents. In addition to their ability to scavenge reactive oxygen species, ACNs can affect the functions Read More

Three-dimensional pharmacophore hypothesis was built based on a set of known Protein tyrosine Phosphatase 1B (PTP1B) agonists using PharmaGist program to understand the essential structural features for Protein Tyrosine Phosphatase 1B (PTP1B) agonists. The various marketed or under development potential glitazones have been opted to build a pharmacophore model e.g. Pioglitazone, Rosiglitazone (BRL-4965 Read More

Understanding and controlling carbohydrate processing enzymes (CPE) have been major issues and challenges for chemists, biochemists and clinical practitioners alike. One of the most powerful families of substances for probing active sites as well as allosteric interactions with CPEs are basic sugar analogues, in particular iminoalditols. This compound class presents a basic trivalent nitrogen instead of oxygen in the sugar Read More

Natural products are important in pharmaceutical research, and many medicines are based on natural products. It is estimated that about 40% of all medicines and about 60% of anti-cancer agents are based on natural products. Plants, marine organisms, amphibians and soil micro-organisms produce cytotoxic compounds to protect themselves or their micro-environment against other organisms and species. It may be benefic Read More