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2000
Volume 12, Issue 2
  • ISSN: 1573-4080
  • E-ISSN: 1875-6662

Abstract

A new series of 1-methyl-4-phenyl-6-substituted-3,4,6,7-tetrahydro-1H-pyrrolo[3,4- d]pyrimidine-2,5-diones (9a-h) were investigated as potential non-nucleoside anti-HCV, through Renilla luciferase (RL) assay using HuH-7-derived OR6 assay system. The target derivatives 9a-h were synthesized in moderate to good yields through nucleophilic substitution, followed by subsequent cyclocondensation of the 6-bromomethyl dihydropyrimidine derivative 8 with the appropriate primary amine. Biological screening revealed that compound 9a (EC50 of 28 μM) showed moderate anti-HCV activity; while compounds 9c, 9e and 9h showed weak activity.

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/content/journals/cei/10.2174/1573408011666151013204142
2016-08-01
2025-05-22
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