Current Cancer Therapy Reviews - Volume 9, Issue 2, 2013

Bone is a common site for metastases in patients with advanced breast or prostate cancer, with greater than 65% of patients developing bone metastases. This is hypothesized to be related to the bone marrow microenvironment providing a favorable niche for cancer cell survival and growth. Circulating tumor cells (CTCs) can colonize bone marrow niches to become disseminated tumor cells (DTCs). Survival of DTCs in Read More

Lung cancer is the leading cause of cancer related deaths worldwide. The prevalence and frequent deaths associated with lung cancer are due in part to the lack of efficient methods to diagnose the disease progression at an early stage and lack of effective novel treatment strategies. Both genetic and epigenetic mechanisms coordinate in the regulation of transcription which in turn works in regulation of cell growth and prol Read More

Magnetic Resonance Imaging (MRI) has established itself as the optimal method for assessing local staging in patients with rectal cancer. This is due to several factors including, most importantly, the ability to accurately delineate the mesorectal fascia and thus determine which rectal tumours threaten the circumferential resection margin (CRM). It is also able to assess depth of tumour penetration into the mesorectum and thu Read More

Pancreatic cancer is a devastating malignancy with a median survival of less than one year. The exceedingly poor prognosis for metastatic pancreatic cancer patients remains a significant unmet medical need and is an opportunity for development of novel therapeutic approaches incorporating gene therapy strategies. Barriers exist preventing effective gene therapy including low transfection efficiency, poor tissue Read More

Background: With improved treatments, a large majority of children (>70%) with central nervous system (CNS) tumors will become long term survivors. These survivors are at risk for adverse long term outcomes, also known as ‘late effects.’ This realization has led to tremendous levels of large scale organizational resources being used to better characterize late effects in an effort to provide evidence-based long term survi Read More

Background: Aberrant activation of the Wnt signaling is one of the most common events in hepatocarcinogenesis. The aim of this study is to investigate the role of methylation modulated APC, AXIN2, APC2 and NKD2 genes expression silencing in hepatitis B virus (HBV) related heptocellular carcinoma (HCC). Methods: Eighty paired tumor and adjacent non-tumor tissues were collected from HCC patients with chr Read More

Retroperitoneal liposarcoma is often asymptomatic but sometimes attention is drawn to the neoplasm due to clinical manifestations. These include fever, flu-like symptoms, nausea or vomiting due to pressure or hypoglycemia related to paraneoplastic disease. We present a rare case of a massive retroperitoneal liposarcoma presenting with refractory dry cough. The patient underwent resection of the mass with complete r Read More

INTRODUCTION: Breast cancer is a serious health problem; 1.3 million women worldwide will be diagnosed with breast cancer each year, 465,000 will die annually. In Mexico, the disease represents 49% of neoplasms in women. Metastatic disease is the main cause of death in women with breast cancer (BC) making it important to identify chemotherapy (CT) schedules that offer the best response rate and palliation. PATIEN Read More