Current Cancer Therapy Reviews - Volume 5, Issue 1, 2009

1,444,920 new cases of cancer were projected in 2007 in the U.S., half of these patients are suffering from cancers of the prostate, the breast, the lung, and the colon/rectum. Colorectal and lung cancer are the most frequent solid tumors in both women and men. However, the US cancer statistics offer some hope. The incidence rates of colorectal and lung cancer rose till 1985 and 1991, respectively after which they fell. G Read More

In modern clinical oncology there is a growing need to diagnose the presence of disease as soon as possible, even when symptoms are not yet present or are minimal, to identify the response to treatment in patients that have been treated and to detect improvement or worsening of the disease as early as possible. Conventional imaging methods that rely on morphologic or structural data are very precise in the delineatio Read More

Chronic secondary lymphedema is a potentially devastating condition affecting 90-150 million people worldwide. In the US, lymphedema is most commonly encountered in the upper extremity of women who have undergone axillary lymph node dissection for staging and treatment of breast cancer, though it may also occur following lymph node dissection for melanoma as well as certain gynecology oncologic operations. Whi Read More

Non-melanoma skin cancer (NMSC) is the most frequent malignancy in the United States, with over one million new cases reported annually. Approximately 80% of NMSC are basal cell carcinomas (BCC), while the remaining 20% of NMSC are squamous cell carcinomas (SCC). BCC and SCC commonly arise in regions of the skin subjected to chronic sun exposure implicating ultraviolet radiation (UV)-induced cellular damage a Read More

Purpose: To conduct a systematic review of available limited sampling strategies (LSSs) for all anticancer (other than platinum) agents and to assess the clinical utility of such models. Design: A literature search was conducted using PubMed and EMBASE up to November 2008. Relevant articles were then categorized according to modified level of evidence guidelines of the U.S. Preventive Services Task Force. Results: Fift Read More

Ovarian cancer is the third-most common cancer of the female reproductive tract, yet it has the highest case fatality ratio of all gynecologic malignancies. Approximately 60% of women diagnosed with epithelial ovarian cancer will die of the disease, because the majority of patients are diagnosed with advanced disease. Surgery followed by chemotherapy is the standard approach to the management of advanced epithel Read More