Current Cancer Therapy Reviews - Volume 3, Issue 2, 2007

Objective: Cancer has been hypothesized being influenced by oxidative stress. Physical activity may offer one means for the influence on possible mechanisms operating on malignancy development. Hypothesis holds that physical activity influences on cell homeostasis. Design: Update the evidence on a link between physical activity and cancer of the colon, rectal and colorectal, breast, prostate, lung, endometrial and ovari Read More

Recent studies of immune responses to pathogens have identified pathogen-associated molecular patterns (PAMPs) recognized by the innate immune system through specialized receptors called toll-like receptors (TLRs). Signaling through these receptors initiates robust immune responses. By exploiting TLR signaling pathways, immunity to tumor- associated antigens may be generated. Many tumor-associated ant Read More

H. pylori is now recognized as one of the most common pathogens afflicting humans, correlated with socioeconomic status and age. In the developed world H. pylori is believed to affect about 50% of people. H. pylori infection was found to be correlated with precancerous lesions, such as chronic atrophic gastritis in the stomach. A long time colonization of human stomach by H. pylori may lead to peptic ulcers, non-Hodg Read More

Novel therapeutic approaches targeting signaling pathways involved in cell proliferation, apoptosis, angiogenesis and metastasis have been under clinical development. Of many potential targets in adult solid tumors, the epidermal growth factor receptor (EGFR) has been the most extensively studied since its over-expression has been observed in several common solid tumors. However, the insurgence for resistance to drugs t Read More

Introduction: The N2 /IIIA Non small cell Lung cancer is a heterogenous group of patients with many differences within the stage that warrant different treatment strategies and have an individual prognosis that varies depending on the size, site and number of lymph node stations involved. Method: Review of the pertinent current literature on the identification of the various subsets of N2 disease and their management and Read More

Clonal lymphoproliferative diseases of large granular lymphocytes (LGL) arise from both CD3-negative and CD3-positive cells, which define NK and T-LGL leukemia, respectively. Chronic neutropenia and anemia represent the most common clinical manifestation of these diseases but lymphocyte infiltration into bone marrow, spleen, and liver also occurs in some cases. The mechanism(s) responsible for expansion of the LGLs are u Read More