Current Cancer Therapy Reviews - Volume 20, Issue 3, 2024

From ancient times until now, scientists have focused on herbal medicaments for treating various diseases. Rottlerin, a potent PKCδ inhibitor, is one of the greatest herbal medications. Over the years, it was identified that rottlerin has several cellular and molecular targets that could be involved in the fight against cancer. The past and present research has clearly shown that rottlerin inhibits the transcription factors, enzymes, an Read More

Matrix metalloproteinase 11 (MMP11), also known as stromelysin-3, is a member of the matrix metalloproteinases family of proteins that are involved in physiological and pathological extracellular matrix remodelling. MMP11 does not hydrolyse classical MMP substrates, such as laminin and fibronectin, and many of its substrates remain unknown, piquing the interest of researchers. Several studies have reported the role Read More

Background: Lung cancer is the second most lethal type of cancer, with a poor survival rate of 5 years. It is one of those malignant tumors that has grown most rapidly in the context of mortality and morbidity. Aim: This review article aims to provide insight into current nanotechnological approaches taken into consideration that provide advantages over conventional chemotherapy. Results and Discussion: After comparing Read More

The study aimed to comprehend the molecular mechanisms and pathophysiology of pancreatic cancer with an emphasis on the advances in treatment options and the use of natural products as anticancer agents. The study involved a literature survey using PubMed, Web of Science and Google scholar database. The literature search was done using keywords “Pancreatic cancer”, “Chemotherapy”, “Mutations”, and “Natu Read More

Photodynamic therapy (PDT) is a non-invasive treatment of cancer patients who take a photosensitizer and expose their tumours to light after administering it topically or intravenously. Understanding apoptosis under oxidative conditions makes PDT a more effective treatment. Tissue oxygen, tumour-selective photosensitizer dyes, and customised lighting are needed to create fatal reactive oxygen species (ROS) in can Read More

Introduction: MicroRNAs (miRNAs) are non-coding RNA molecules with short sequences that function as main post-transcriptional gene regulators of different biological pathways via negative regulation of gene expression, thereby leading to either mRNA degradation or translational blockade. Dysregulated expression of these miRNAs has been related etiologically to many human diseases, including breast cancer. Various cellul Read More

Background: Human Papilloma Virus (HPV) infection and its persistence are responsible for the development of cervical cancer (CaCx). Chemoradiotherapy (CRT) is the only treatment option, especially in advanced stages. However, it is not influenced by the status of HPV infection. CRT controls cancer growth along with mild to severe adverse effects. Objective: The aim of this study was to assess the HPV-associated Read More