Current Cancer Therapy Reviews - Volume 15, Issue 1, 2019

Background: Bioinformatics is an interdisciplinary field that combines biology and information technology to study how to deal with the biological data. The DNA motif discovery problem is the main challenge of genome biology and its importance is directly proportional to increasing sequencing technologies which produce large amounts of data. DNA motif is a repeated portion of DNA sequences of major biological in Read More

Colon cancer is one of the most common and most diagnosed types of cancer. It is a major cause of increased rate of morbidity and mortality across the globe. Currently, the focus has been shifted towards natural remedies for the treatment of colon cancer. These new methods of treatment include prebiotics and probiotics, as they offer great potential for alleviating symptoms of cancer. These are more promising Read More

Background: Cancer is the second leading cause of death globally and accounted for 8.8 million deaths annually in humans. Lung, prostate, colorectal, stomach and liver cancer are the most common types of cancer in men, while breast, colorectal, lung, cervix and stomach cancer are the most common among women. Numerous drugs that the US Food and Drug Administration (FDA) have approved for use in cancer th Read More

Background: Although well established for the effective management of hematologic cancers, maintenance chemotherapy has only been recently incorportated as a treatment paradigm for advanced non–small-cell lung cancer. Maintenance chemotherapy aims to prolong a clinically favorable response state achieved after finishing induction therapy which is usually predefined in number before startng treatment. There are 2 m Read More

Background: With the advent of changes in lifestyle of people all around the world, cancer cases have been showing an exponential rise. Researchers from varied fields have been trying to solve this tricky issue. Methods: We undertook a systematic search of bibliographic databases of peer-reviewed research literature to evaluate the holistic blend of modern and traditional approaches, especially the Ayurvedic perspect Read More

Introduction: The issues of carcinoma drug resistance to alkylating agents such as Temozolomide (TMZ) are considered as a major concern in therapeutics. The potential ways to achieve better cancer cell growth arrest and cytotoxicity have been suggested including the combinatorial use of DNA repair protein inhibitors and genotoxic drug TMZ. Here, authors assess the ability of DNA ligase inhibitor (L189) to modulate TMZ Read More

Introduction: Protease Inhibitors (PIs) constitute a group of proteins widely distributed among all organisms and their main function includes their ability to inhibit the proteolytic activity. PIs represent an important role in the regulation of various cellular physiological and biological processes, including cell cycle, cell death, differentiation and immune response. Material and Methods: Hence, in our search for novel anticancer co Read More