Current Cancer Therapy Reviews - Volume 10, Issue 3, 2014

p38α MAPK, a key therapeutic target in HNSCC can be considered as a prognostic marker and is implicated in response to radiation-therapy (RT). We compared the outcome of treatment viz. RT (group-I) and concurrent-RT (combination of RT with chemotherapy or surgery, group-II) with respect to p38α MAPK in HNSCC. The case-controlled study was performed on 143 HNSCC patients. From these p38α estimation was do Read More

The development of effective chemotherapy or endocrine therapy has significantly improved survival among patients with breast cancer, and recently molecular cancer therapeutics is emerging as another new approach. The human epidermal growth factor receptor (HER) family of receptor tyrosine kinases is an attractive target for anticancer strategies. Trastuzumab is a humanized monoclonal antibody that binds d Read More

The change of the entropy is the arrow of understanding spontaneous processes in complex systems. The entropy production is the sum of several entropy flows resulting in collective entropy, which determines the direction of individual entropy flows in a biological system. In case of cancer patients these thermodynamical terms have a key role in the tumor development on the expense of the host integrity. The life develops Read More

Hydrogels have emerged as an unique and potential transporters for the target drug delivery systems in cancer therapy. Cancer is a terrible disease extracting toll on human health across the world probably due to several drawbacks of the conventional cancer treatments. However, hydrogels facilitate the modern and improved prospects for the treatment of cancer with minimum cytotoxic effects to the healthier cell Read More

Abnormalities in microRNA expression in tumor cells are widely used as a basis to develop novel therapeutic and diagnostic approaches in oncology. The former mostly aims to target oncogenic microRNAs or to restore expression of microRNAs with tumor suppressor properties in cancer cells. However recently another way of using specific microRNA loss in tumor cells has been suggested. The strategy relies on frequently lost i Read More

Hepatocellular carcinoma (HCC) is a leading cause of cancer deaths worldwide and the incidence and mortality rate are nearly identical in the United States. The Milan Criteria established thresholds of tumor size and number as predictors of optimum overall survival with liver transplant and changed the definitive treatment for HCC. However, after nearly two decades of experience two problems have emerged: post-transpla Read More

Non-small cell lung cancer (NSCLC) accounts for more deaths than any other cancer. Treatments are limited, and prognoses are usually very poor. Amitripyline is a tricyclic antidepressant with multiple effects which may give a variety of benefits to lung cancer patients. Effects on pain, mood, and sleep are of clear potential benefit and are well established, whereas effects on cough and respiratory function are currently under i Read More