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Volume 21, Issue 2
  • ISSN: 1573-3947
  • E-ISSN: 1875-6301

Abstract

Introduction

Skin cancer is the fifth most common cancer and is a serious concern to public health and the economy. Although, various treatment strategies are available but have several undesirable side effects. To combat these drawbacks, phytoconstituents or herbs can be the best choice. (prishniparni) is a potential herb used in various herbal formulations, important of which is Dasmularishta.

Methods

Thus, the present study aims to investigate the antioxidant and chemopreventive potential of root extract as an alternative for skin cancer prevention or treatment. The powdered plant material was successively extracted with petroleum ether, methanol, and water. The obtained methanol and aqueous extracts were studied for antioxidant activity DPPH free radical scavenging assay using butylated hydroxytoluene as a standard. Both the extracts showed significant antioxidant activity with IC values of 9.17 and 15.6 µg/mL, respectively while BHT had IC value of 7.03 µg/mL. Female Swiss albino mice were selected for the study and randomly divided into 7 groups having 6 animals each. The skin carcinogenesis was induced using a single application of DMBA on dorsal shaved skin and promoted by applying croton oil twice weekly till the end of the study . 16 weeks.

Results

Both the extracts showed the chemopreventive potential in a dose-dependent manner. The most significant activity was observed with the methanol extract at 400 mg/kg, p.o. dose. The present study showed significant antioxidant and antitumorigenic activity of the methanol extract of roots against chemical-induced skin papillomagenesis.

Conclusion

The precise mechanism of action and constituents responsible for the activity are still under further study.

© 2025 Bentham Science Publishers
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2024-10-23
2025-05-31

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Antioxidant and Chemopreventive Potential of Uraria picta Root Extracts against DMBA/croton Oil Induced Skin Carcinogenesis in Mice
Curr Cancer Ther Rev 21, 229 (2025); https://doi.org/10.2174/0115733947316390240805063416
/content/journals/cctr/10.2174/0115733947316390240805063416
/content/journals/cctr/10.2174/0115733947316390240805063416
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  • Article Type:     Research Article
Keyword(s): antioxidant; carcinogenesis; Chemoprevention; croton oil; prishniparni; skin cancer

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