Combinatorial Chemistry & High Throughput Screening - Volume 27, Issue 5, 2024

Objective: Gene expression profile data is a good data source for people to study tumors, but gene expression data has the characteristics of high dimension and redundancy. Therefore, gene selection is a very important step in microarray data classification. Methods: In this paper, a feature selection method based on the maximum mutual information coefficient and graph theory is proposed. Each feature of gene expression Read More

Background: Topological indices have a significant role in determining a molecule’s topology in the light of theoretical chemistry. Objectives: This study aimed to find new bounds for some eccentric-based topological indices. Methods: We used comparison theorem for integrals. Results: We found new bounds for the eccentric-based harmonic index and atom-bond connectivity index. Our results are better than previous result Read More

Background: Dominating David-derived networks are widely studied due to their fractal nature, with applications in topology, chemistry, and computer sciences. The use of molecular structure descriptors is a standard procedure that is used to correlate the biological activity of molecules with their chemical structures, which can be useful in the field of pharmacology. Objective: This article's goal is to develop analytically cl Read More

Severe SARS-CoV-2 infection is linked with an overstated immune response with the succeeding release of pro-inflammatory cytokines and progression of the cytokine storm. In addition, severe SARS-CoV-2 infection is associated with the development of oxidative stress and coagulopathy. Dapsone (DPS) is a bacteriostatic antibiotic that has a potent anti-inflammatory effect. Thus, this mini-review aimed to elu Read More

Background: Vicatia thibetica de Boiss is a common Tibetan medicine used for both medicine and food, belonging to the family Apiaceae. This plant has the functions of dispelling wind, removing dampness, dispersing cold, and relieving pain. It has great development potential and application prospects in food development and medicinal value. Methods: The related references on botany, traditional uses, phytochemistry, quant Read More

Sepsis refers to the dysregulated host response to infection; its incidence and mortality rates are high. It is a worldwide medical problem but there is no specific drug for it. In recent years, clinical and experimental studies have found that many monomer components of traditional Chinese medicine have certain effects on the treatment of sepsis. This paper reviews the advances in research on the active ingredients of tradit Read More

The role of medicinal plants has been advantageous due to their manifestation through various cellular and molecular mechanisms. Inhibition of the monoamine oxidase enzyme is suspected to be a highly effective treatment for various neurological illnesses like Alzheimer's disease, Parkinson’s disease, depression, social phobia, and panic disorders. The study of phytochemicals and plant extracts used as a traditional Read More

Background: Malignant gliomas are the most common type of primary malignant brain tumors. Pantothenate kinase 1 (PANK1) mRNA is highly expressed in several metabolic processes, implying that PANK1 plays a potential role in metabolic programming in cancers. However, the role of PANK1 in glioma has not been fully explored. Methods: Public datasets (The Cancer Genome Atlas (TCGA), Chinese Glioma Genome Atlas Read More

Background: Osteosarcoma is a disease that primarily affects adolescents with skeletal immaturity. LncRNAs are abnormally expressed and correlated with osteosarcoma patients' prognosis. We identified aberrant expression of LncRNA SNHG25 (small nucleolar RNA host gene 25) in osteosarcoma and analyzed the molecular mechanisms by which it regulates osteosarcoma progression. Methods: The expression level Read More

Background: Hypertension is notably a serious public health concern due to its high prevalence and strong association with cardiovascular disease and renal failure. It is reported to be the fourth leading disease that leads to death worldwide. Objectives: Currently, there is no active operational knowledge base or database for hypertension or cardiovascular illness. Methods: The primary data source was retrieved from the resea Read More

Introduction: Cervical cancer is one of the malignant cancers with high mortality among women worldwide. Although vaccines and early detection have reduced cervical cancer mortality, it remains a malignancy with a high mortality rate in women. Objectives: We aimed to develop a novel integrated strategy that combines metabolomics with network pharmacology to explore the therapeutic mechanisms of naringin in cervi Read More

Aim and Objective: Synthetic antioxidants and anti-inflammatories are widely used by the food and pharmaceutical industries. Like any synthetic product, these are toxic and represent a significant health risk. The objective of this study was to determine the chemical composition of Anacyclus valentinus essential oil and its oxygenated fraction, as well as their in-vitro antioxidant and anti-inflammatory properties. Methods: The e Read More

Background: Fuzi-Gancao herb couple is one of the most common herb couples involved in the TCM formula, which was used for the treatment of chronic diseases. The herb couple has a hepatoprotective effect. However, its main components and therapeutic mechanism are not yet clear. This study aims to elucidate the therapeutic effect and mechanism of the Fuzi-Gancao herb couple on NAFLD from animal experiments, netw Read More

Objective: Diabetic osteoporosis (DOP) belongs to the group of diabetes-induced secondary osteoporosis and is the main cause of bone fragility and fractures in many patients with diabetes. The aim of this study was to determine whether Ziyin Bushen Fang (ZYBSF) can improve DOP by inhibiting autophagy and oxidative stress. Methods: Type 1 diabetes mellitus (T1DM) was induced in rats using a high-fat high-sugar diet combined Read More