Combinatorial Chemistry & High Throughput Screening - Volume 26, Issue 15, 2023

2-Arylpropionic acid nonsteroidal anti-inflammatory drugs (NSAIDs) provide one of the most demonstrated pharmaceutical examples of chiral inversion. Chiral inversion depends on various factors (viz. biological-, solvent-, light-, temperature-induced, etc.) and the energy barrier associated with the stereogenic element present in the chiral molecule. The pharmacological properties of chiral drugs depend on the activity of on Read More

The recent development of monolithic chiral stationary phases (CSPs) for liquid chromatography (LC) is mainly focused on reducing backpressure, maximizing flow rates, faster run time, column efficiency, and stability. This review paper emphasizes recent progress in the development of polysaccharide and cyclodextrin-based monolithic CSPs. Further the paper draws attention to competing techniques, like non-porous par Read More

Biogenic amines (BAs) are compounds deemed to be foodstuff contaminants and are the cause of poisoning or allergy. The main BAs found in foods include histamine, tyramine, putrescine, cadaverine, spermine and spermidine. The number of poisoning cases related to BAs in food has increased, which is reinforcing the need for BAs detection to ensure food safety. BAs are found in varying quantities in different foods su Read More

Drug degradation is a process that can render pharmaceuticals inactive without causing any visible distortion. This can disrupt the therapeutic process, and on occasion, when the process produces toxic metabolites, it can have much more fatal consequences. Light is one of the most significant components that might cause deterioration, and several attempts have been made to improve and increase the practical ph Read More

The electrochemical detection of neurotransmitters is an imperative application in the field of analytical chemistry. The recent development in the electrochemical sensors based on carbon electrodes is very important due to their sensitivity and simplicity. Using the carbon-based sensor for the electrochemical analysis of the neurotransmitters is a simple method. Furthermore, these above methods provide high sensitivity, are u Read More

Rice (Oryza sativaL.), a cereal grass, belongs to the genus Oryzafrom the family Poaceae, which encompasses twenty-five species cultured in many countries of Asia, and partly in the rest of the world. From these species, two viz. Oryza sativa(O. sativa.) Asian rice and Oryza glaberrima. (O. glaberrima.) African rice are commonly found and the most widely consumed staple food by a large part of the human population in the Read More

Mepivacaine, an amide-type local anesthetic drug widely used in regional anesthesia, was studied by some aspects such as electrochemical behavior, mechanism illumination, and analytical applications by cyclic voltammetry (CV) and different pulse voltammetry (DPV) methods. In this study, a novel, fast, simple, portable, and the inexpensive electrochemical sensor was developed for the determination of mepivacaine. Read More

Introduction: In drug analysis, using non-hazardous solvents instead of the ones harmful to humans and the environment is a green strategy to protect analysts and environmental health. Objective: Procainamide (PCA) is an antiarrhythmic drug requiring therapeutic drug monitoring (TDM) because of its narrow therapeutic window and serious side effects. Aim: The aim of this study is to develop validated green HPLC metho Read More

PCSK9 (proprotein convertase subtilisin/kexin type 9) is an enzyme that helps to reduce cardiovascular events. This clinical result is attributable primarily to the crucial involvement of PCSK9 in regulating the low-density lipoprotein cholesterol level. Because oral anti-PCSK9 medications have yet to be available, the benefits of this unique treatment approach have been diminished. Identifying naturally occurring PCSK9 inhibitor Read More

Background: Bioautography is a technique for the detection of biological activity that combines the elements of planar chromatography. Its hyphenated variants are widely used in the screening of natural products possessing biological activity. It can be used in the activity-based screening of phytochemical ingredients by employing various enzyme processes and reactions and facilitates the rapid determination of Read More

Background: Dendrobium nobileLindl. (DNL) is effective for the treatment of alcoholic liver disease (ALD), but the underly mechanism is still unclear. Objectives: This research aimed to investigate the effects and mechanism of the aqueous extract of Dendrobium nobileLindl (AEDNL) in ALD rats based on a metabolomics approach. Materials and Methods: In this study, 18 Sprague-Dawley male rats were randomly divided into con Read More

Aim: To determine whether or not a decoction made from Qigu Zhushui has a suppressive impact on malignant ascites in mice. Background: Malignant ascites are one of the common complications of advanced malignant tumors. Patients with malignant ascites typically have a poor prognosis, with only 12 to 20 weeks of survival. Currently, the standard treatments for malignant ascites are systemic chemotherapy, w Read More

Background: Acute Liver Failure (ALF) is a difficult problem to solve in clinical practice. The presence of non-SMC condensin I complex subunit G (NCAPG) has previously been linked to vascular invasion of digestive system tumors, foreshadowing poor prognosis. Its role in ALF biology, however, remains unknown. This article explores the role of NCAPG as a potential biomarker candidate for the accurate diagnosis and targeted tr Read More