Combinatorial Chemistry & High Throughput Screening - Volume 20, Issue 7, 2017

Background: Lantibiotics, which are usually produced from Gram-positive bacteria, are regarded as one type of special bacteriocins. Lantibiotics have unsaturated amino acid residues formed by lanthionine (Lan) and β-methyllanthionine (MeLan) residues as a ring structure in the peptide. They are derived from the serine and threonine residues and are essential to preventing the growth of other similar strains. Method: In t Read More

Aim and Objective: The Krüppel-like factors (KLFs) are a family of containing Zn finger(ZF) motif transcription factors with 18 members in human genome, among them, KLF18 is predicted by bioinformatics. KLFs possess various physiological function involving in a number of cancers and other diseases. Here we perform a binary-class classification of KLFs and non-KLFs by machine learning methods. Material and Method: The p Read More

Background: The cell cycle-regulated genes express periodically with the cell cycle stages, and the identification and study of these genes can provide a deep understanding of the cell cycle process. Large false positives and low overlaps are big problems in cell cycle-regulated gene detection. Methods: Here, a computational framework called DLGene was proposed for cell cycle-regulated gene detection. It is based o Read More

Aim and Objective: Correct prediction of protein structural class is beneficial to investigation on protein functions, regulations and interactions. In recent years, several computational methods have been proposed in this regard. However, based on various features, it is still a great challenge to select proper classification algorithm and extract essential features to participate in classification. Material and Methods: In this study, a Read More

Aim and Objective: Protein malonylation is a newly discovered post-translational modification. Malonylation is known to closely be associated with type 2 diabetes and to play its regulatory role in fatty acid oxidation and the associated genetic disease. Identifying protein malonylations might lay a solid foundation to explore malonylation function. Due to the limitations of experimental techniques, it is a great challenge to fast and Read More

Aim and Objective: Lysine acetylation, as one type of post-translational modifications (PTM), plays key roles in cellular regulations and can be involved in a variety of human diseases. However, it is often high-cost and time-consuming to use traditional experimental approaches to identify the lysine acetylation sites. Therefore, effective computational methods should be developed to predict the acetylation sites. In this stud Read More

Background: Ebola hemorrhagic fever (EHF) is caused by Ebola virus (EBOV). It is reported that human could be infected by EBOV with a high fatality rate. However, association factors between EBOV and host still tend to be ambiguous. Objective: According to the “guilt by association” (GBA) principle, proteins interacting with each other are very likely to function similarly or the same. Based on this assumption, we tried Read More

Background: Most patients with early stage endometrial endometrioid adenocarcinoma (EEAC) are treated with hysterectomy and bilateral oophorectomy. But this surgical menopause leads to long-term sequelae for premenopausal women, especially for young women of childbearing age. This population-based study was to evaluate the safety of ovarian preservation in young women with stage I EEAC. Methods: Patien Read More