Materials Etiquette and Complement Responses

The complement system is a central constituent of innate immunity orchestrating and bridging various responses during immune and inflammatory reactions. As such, the role of complement system in nanomedicine, in terms of functionality and performance, is multifaceted. This commentary considers the role of complement in regulation and synchronization of 1) nanoparticle opsonisation and macrophage clearance, 2) nanoparticle adjuvanticity, 3) nanomedicine-mediated acute injection reactions and 4) cancer progression on nanoparticle accumulation in solid tumours.