Current Biotechnology - Volume 13, Issue 2, 2024

Inflammation is crucial for maintaining tissue homeostasis and responding to insults, yet dysregulated inflammation can lead to various diseases. Macrophages, central to the immune system, play key roles in initiating, regulating, and resolving inflammation. This review provides an overview of macrophage functions, including activation mechanisms, recruitment to inflamed tissues, interactions with other immune cells and m Read More

The efficacy of synthetic drugs in managing disease development and progression has faced challenges amidst shifts in lifestyle and heightened health consciousness. As a result, medicinal plants and seeds, with their constituent compounds, are gaining recognition for their potential in treating various illnesses. Ginger and flaxseed, as long-established herbal remedies, have made notable contributions to culinary and m Read More

The morbidity and death rates linked to diabetes mellitus are substantially increased by foot ulcers, a prevalent consequence of the disease. Proper wound management is essential for controlling foot ulcers. This includes monitoring the ulcers' healing progress through clinical reviews, changing dressings as needed, treating infections with the right medications, and ensuring that the ulcer is offloaded correctly. Taking pictures of t Read More

Fungi infections are responsible for more than 1.6 million deaths per year worldwide. Treatment is time-consuming, compromising the kidney and liver functions. In silico analyses have facilitated the discovery of new drugs that may present fewer side effects. In this connection, kinases that phosphorylate the translation initiation factor eIF-2 are candidate proteins for potent new drugs, which have been recognized as import Read More

Background: The biological function of α-Synuclein (α-Syn), which includes controlling synaptic vesicles, is regulated by phosphorylation at the Tyrosine 39 (pY39) residue. This function can be important for both normal and aberrant functions, and it relies on the interaction of α-Syn with the lipid membrane. pY39 α-Syn is found to form morphologically distinct fibrils relative to wild-type (WT) α-Syn and shows less affinity to ne Read More