Current Biotechnology - Volume 13, Issue 1, 2024

Cholesterol metabolism is a crucial mechanism for preserving cellular functionality, and overall human health. Cardiovascular diseases and other conditions can arise due to dysregulation of cholesterol levels. Bile acids’ enterohepatic circulation greatly influences cholesterol homeostasis. Recent research has emphasized the essential role of the gut microbiota in bile acid metabolism and its association with cholesterol reg Read More

Polycystic ovary syndrome (PCOS) is a common endocrinopathy characterized by excess androgen and infertility due to anovulatory failure. A significant fraction of the world's population is affected by the infertility condition known as PCOS. Due to the disease's complicated nature and overlapping symptoms, diagnosis of the condition is frequently challenging. Exogenous compounds or combinations known as endocrine Read More

Among the various technological advancements in different fields that help fulfill our needs further, marine biotechnology is one that has brought a significant change in the overall bleak outlook of the limited resources that the oceans have to offer. Marine biotechnology has not just revolutionized the method of farming and increased productivity, but it has also ensured a consistent supply to various cuisines through Read More

Background: Acute lymphoblastic leukemia (ALL) is characterized by an imbalance in the production and development of hematopoietic lymphoid cells, a malignant disease capable of affecting the proliferation-selection of hematopoietic cells. The Aurora kinase A protein participates in several steps of the mitosis process. Its deregulation can trigger the process of carcinogenesis, which has become a therapeutic target of intere Read More

Background: Cystinosis is a rare inherited lysosomal storage disease (LSD), caused by a mutation in the Cystinosin Lysosomal Cystine Transporter (CTNS). Novel therapies and strategies are needed to improve patients' clinical conditions and quality of life. Objectives and Methods: This study assessed whether CTNS can be secreted, and investigated a method to enhance its secretion, by adding a secretion signal to the N-term Read More

Background: Explant recalcitrance is one of the major challenges during the tissue culture of a tree species, especially when explants are derived from mature plants. It is mainly associated with the genotypes/species, source and physiological status of explants, seasonal variations, and competency/incompetency of explants towards PGRs for in vitro manipulations. Therefore, to optimize the appropriate conditions and m Read More