Current Bioinformatics - Volume 14, Issue 5, 2019

Objective: The purpose of this study was to establish whether Triglycerides (TGs) are related to Blood Pressure (BP) variability and whether controlling TG levels leads to better BP variability management and prevents Cardiovascular Disease (CVD). Methods: In this study, we enrolled 106 hypertensive patients and 80 non-hypertensive patients. Pearson correlation and partial correlation analyses were used to define the rel Read More

Background: HIF-1α can affect the apelin expression and participates in the developments in cancers but the mechanism need to be explored further. Objective: This paper investigates apelin expression in nasopharyngeal carcinoma CNE-2 cells and its regulation by hypoxia inducible factor-1α (HIF-1α) under hypoxic conditions. Methods: CoCl2 was used to induce hypoxia in CNE-2 cells for 12h, 24h and 48h. HIF-1α small inter Read More

Background: CYP2C19 is an important genetic factor modulating clopidogrel dose requirement. Objective: Therefore, a simple and economic genotyping method for predicting the clopidogrel dose of patients would be useful in clinical applications. Methods: In this study, the MGB blocker ARMS real-time PCR contained two forward primers, two MGB blockers and a common reverse primer have been used for CYP2C19*2, * Read More

Objective: This research aimed to make comparisons of sensitivity and specificity between Quantitative real Time Polymerase Chain Reaction (Q-PCR) and Reverse Transcription PCR (RT-PCR) in detecting the ribonucleic acid (RNA) expression levels of Hepatitis C Virus (HCV). Methods: 121 patients suffering from hepatitis C and 98 healthy participants with normal liver functions were identified. The venous blood collections Read More

Background: Revealing the subcellular location of a newly discovered protein can bring insight into their function and guide research at the cellular level. The experimental methods currently used to identify the protein subcellular locations are both time-consuming and expensive. Thus, it is highly desired to develop computational methods for efficiently and effectively identifying the protein subcellular locations. Especially, th Read More

Background: Mining knowledge from microarray data is one of the popular research topics in biomedical informatics. Gene selection is a significant research trend in biomedical data mining, since the accuracy of tumor identification heavily relies on the genes biologically relevant to the identified problems. Objective: In order to select a small subset of informative genes from numerous genes for tumor identification, vari Read More

Background: MicroRNAs (miRNAs) are small non-coding RNAs that control gene expression at the post-transcriptional level through complementary base pairing with the target mRNA, leading to mRNA degradation and blocking translation process. Many dysfunctions of these small regulatory molecules have been linked to the development and progression of several diseases. Therefore, it is necessary to reliably predict potenti Read More

Background: With the declining trend of new drugs yield each year, more comprehensive knowledge of drug MoAs can help identify new applications of available drugs and discovery novel mechanism of drug action. Objective: Therefore, construction of a specialized drug mode of action (MoA) database is of paramount importance for new drug research & development. Methods: This paper introduces an integrate Read More

Background: Leishmaniasis is the major cause of mortality in under-developed countries. One of the main problems in leishmaniasis is the limited number of drug options, resistance and side effects. Such a situation requires to study the new chemical series with anti-leishmanial activity. Objective: To assess the anti-leishmanial activity of antibacterial and antifungal drugs. Methods: We have applied an integrative approac Read More

Background: Neurodevelopmental Disorders (NDDs) are impairment of the growth and development of the brain or central nervous system, which occurs at the developmental stage. This can include developmental brain dysfunction, which can manifest as neuropsychiatric problems or impaired motor function, learning, language or non-verbal communication. These include the array of disorder, including: Autism Spectr Read More