Current Bioinformatics - Volume 14, Issue 6, 2019

Background: Although most nucleotides in the genome form canonical double-stranded B-DNA, many repeated sequences transiently present as non-canonical conformations (non-B DNA) such as triplexes, quadruplexes, Z-DNA, cruciforms, and slipped/hairpins. Those noncanonical DNAs (ncDNAs) are not only associated with many genetic events such as replication, transcription, and recombination, but are also related to Read More

Background: Predicting the value of gene expression in a given condition is a challenging topic in computational systems biology. Only a limited number of studies in this area have provided solutions to predict the expression in a particular pattern, whether or not it can be done effectively. However, the value of expression for the measurement is usually needed for further meta-data analysis. Methods: Because the problem Read More

Background: DNA microarray technology allows researchers to measure the expression levels of thousands of genes simultaneously. The main objective of microarray gene expression (GE) data analysis is to detect biomarker genes that are Differentially Expressed (DE) between two or more experimental groups/conditions. Objective: There are some popular statistical methods in the literature for the selection of biomarker ge Read More

Background: In recent years, the rapid growth of biological datasets in Bioinformatics has made the computation of Multiple Sequence Alignment (MSA) become extremely slow. Using the GPU to accelerate MSA has shown to be an effective approach. Moreover, there is a trend that many bioinformatic researchers or institutes setup a shared server for remote users to submit MSA jobs via provided web-pages or tools. Obje Read More

Background: Complex prediction from interaction network of proteins has become a challenging task. Most of the computational approaches focus on topological structures of protein complexes and fewer of them consider important biological information contained within amino acid sequences. Objective: To capture the essence of information contained within protein sequences we have computed sequence entropy Read More

Background: Previous studies have revealed that DNA methylation plays a crucial role in eukaryotic growth and development via involvement in the regulation of gene expression and chromosomal instability. With the advancement of biotechnology, next-generation sequencing (NGS) is emerging as a popular method to explore the functions of DNA methylation, and an increasing number of genome-scale DNA methylation dataset Read More

Background: Clostridium tetani are rod-like, anaerobic types of pathogenic bacteria of the genus Clostridium. It is Gram-positive in nature and appears as a tennis racket or drumsticks on staining with the dye. Tetanus is a neuromuscular disease wherein the Clostridium tetani exotoxin produces muscle fits in the host. Tetanus is the second leading cause of worldwide deaths occurring from the family of immunization-pre Read More

Background: Leishmaniasis is a disease caused by the Leishmania sp. and can be classified into two major types: cutaneous and visceral leismaniasis. Visceral leishmaniasis is the deadlier type and is mediated by Leishmania donovani and involves the establishment of persistent infection and causes damage to the liver, spleen and bone marrow. With no vaccine yet available against leishmaniasis and the current t Read More

Background: Time series expression data of genes contain relations among different genes, which are difficult to model precisely. Slime-forming bacteria is one of the three major harmful bacteria types in industrial circulating cooling water systems. Objective: This study aimed at constructing gene regulation network(GRN) for slime-forming bacteria to understand the microbial fouling mechanism. Methods: For this purpose, an Read More