Current Bioactive Compounds - Volume 14, Issue 1, 2018

Background: Living organisms are a natural source of β-amino acids and peptides containing them. Many marine organisms and plants are able to produce by themselves such compounds, e.g. depsi-peptides and macrocyclic molecules, which possess different biological activities, mostly concerned to the treatment of human diseases. Methods: Literature has been collected ranging from 1980 until now; both reviews and r Read More

Background: The oxadiazine insecticides are broad-spectrum insecticides with a novel mode of action by blocking insect neuronal sodium channels. Indoxacarb is an oxadiazine insecticide to reduce cross-resistance. A series of tricyclic oxadiazine analogues were designed and synthesized in order to find novel active compounds with high bioactivities similar to that of the commercial insecticide indoxacarb. Methods: We under Read More

Background: Passion fruit is known to be rich in flavonoids and can be an important antioxidant, preventing the oxidative damage. The objective of this study was first to evaluate the antioxidant activity of Passiflora alata fruit extract in the liver of Wistar rats and second to compare the efficacy of pretreatment or co-treatment of this extract. Method: Antioxidant activity of Passiflora alata fruit extract was analyzed by lipid peroxi Read More

Background: In the present study, a series of substituted phenyl β,β-diphenylpropanoate were synthesized by the reaction of β,β-diphenylpropionyl chloride with various substituted phenols in acetone. Methods: Upon synthesis of compounds, the characterization of synthesized compounds was made using IR, NMR, Mass spectroscopy and elemental anaysis. These derivatives were screened for analgesic activity and anti-inflamm Read More

Background: Prazequantel (Prz) is an important medication in humans and animals. It acts against a number of pathogens. In this study, Prz nanoemulsion (PrzNE) was prepared and evaluated for toxic, cytotoxic and mutagenic potentials. Materials and Methods: The cytotoxic effect of PrzNE was observed in Artemia salina and Allium cepa, while toxicity and mutegenicity in A. cepa test system. Potassium di-chromate (K Read More

Background: Chalcones holding arylic substitutions and pyrazolic chalcones were reported as potent antimicrobial and antioxidant agents. Prompted by the literature, it was considered of interest in the present work to develop the bioactive materials incorporating five, and six-membered ring heterocycles in a single molecular framework with above molecules. Methods: Synthesis of chalcone derivatives derived Read More

Background: Praziquantel (Prz)-induced membrane permeability causes cell death of organisms. It may have antioxidative/pro-oxidative capacity. The aim of this study was to prepare Prz nanoemulsion and evaluate antioxidant capacity. Materials and Methods: Radical scavenging capacity was checked by 1,1-dipheny-picrylhydrazyl (DPPH), azino-bisethylbenzthiazoline-sulfonic acid (ABTS); hydroxyl (OH) and nitrite oxide (NO) rad Read More

Background: A variety of methods have been reported for the synthesis of pyrano[2,3- d]pyrimidines in the literature. Many of these methods are associated with some limitations and generally need expensive or non-available reagents, prolonged reaction times and high temperatures. Thus, the introduction of new methods and /or further work on technical improvements to overcome these limitations is still needed. Pyrano[2 Read More

Background: Several Serratula species are used in folk medicine and showed interesting biological activities. The objective of this work was to continue the investigation of the chemical composition of the ethyl acetate extract of the flowers of Serratula cichoracea which in our previous study showed a significant antioxidant activity in 1,1-diphenyl-2-picrylhydrazyl radical (DPPH•) essay compared to quercetin used as con Read More

Background: 2-phenylethylamine (2-PEA) is an organic neurotransmitter which belongs to a class of biogenic amines that are essential for regulation of cellular development, differentiation and homeostasis. This class of compounds have been reported to cause oxidative stress to neuronal cells in the brain, which have a high oxygen consumption rate, elevated iron content and low antioxidant concentration. 2-phe Read More

Background: According to the Indian traditional system of medicine, Paederia foetida L. (Rubiaceae) is considered as the most valuable drug for numerous protective effects against different types of metabolic diseases and disorders such as inflammation, arthritis, pain, etc. To date, no study has been undertaken to scrutinize the systemic and topical anti-inflammatory effect of Paederia Foetida L. The present study is an attem Read More

Background: Salvia species contain bioactive secondary metabolites and possess several pharmacological activities. The objective of this study was to determine the chemical composition and antimicrobial activity of essential oil from the aerial parts of Salvia pachystachys. Methods: The essential oil was obtained by means of hydrodistillation and its components were analyzed using gas chromatography and mass spectro Read More

Background: Alzheimer disease is a neurological disease related to age which is characteristic of excess of oxidative stress and deficit level of acetylcholine in the brain. Centella asiatica (Linn.) have several beneficial pharmacological activities such as antioxidant, anti-inflammatory and memory enhancing activities. Objective: To evaluate the phenolic contents, antioxidant and AChE inhibitory activities of different fraction Read More

Brackground: In our previous study, we have shown that the ethanol, chloroform and nhexane extracts of Dysophylla auricularia revealed antimicrobial, anti-diarrheal, anti-inflammatory and membrane stabilization, alpha-glycosidase inhibitory and antipyretic activities. This study aims to evaluate the antioxidant capacity of methanol extract of D. auricularia (MDA) using some non-clinical test systems. Materials and Met Read More