Current Bioactive Compounds - Volume 10, Issue 4, 2014

The exploitation of the antitumor properties of fungal secondary metabolites is one of the fundamental objectives pursued by a multiplicity of research groups and laboratories working on the characterization of natural products worldwide. The availability of a synthetic framework on such a vast interdisciplinary topic can enhance the current knowledge by supporting novel findings, and stimulating further insights. This pape Read More

A simple and sensitive red spectrofluorimetric method has been described for the estimation of hypocrellin B in rabbit plasma and ocular tissues such as retina, iris, aqueous humour and vitreous body. The fluorimetric estimation was achieved using black coloured 96- well plate at an excitation/emission wavelengths of 470/620 nm with a specific well volume of 100 µL/well. Hypocrellin B calibration curves were linear at Read More

Alzheimer’s disease (AD), a progressive neurodegenerative disease has become one of the major health issues in developed countries. Continuing our research on biological activity of coumarin derivatives, this study presents evaluation of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity of series 4- methylcoumarins. All studied compounds showed inhibitory activity in a similar manner as they are Read More

Three series of novel bile acid conjugates with different α–amino acid have been synthesized. The synthesis of final compounds was accomplished with anhydride using ethyl chloroformate. The conjugation was introduced via coupling of the bile acid anhydride with appropriately functionalized α-amino acid. Biological evaluation of synthesized compounds was carried out in vitro for their antimicrobial and antifungal properties a Read More

The optimization and kinetic of rosmarinic acid extraction from Orthosiphon stamineus were investigated in this study. In the preliminary study, the extractions were carried out to identify the optimal ethanol concentration. Then, the optimal ethanol concentration was used to optimize the extraction variables (solventto- solid loading ratio, temperature and time) by central composite design. The optimum conditions for the r Read More

Benzazolo[3,2-a]quinolium salts (BQS) are cationic quaternary alkaloids with similar structure to the anticancer agent ellipticine. This study describes the synthesis and screen, at the experimental concentration of 10 mM, utilizing the 60 cell line anti-cancer screening of two BQS, namely, 7-benzyl-3- aminobenzimidazo[3,2-a]quinolinium chloride (ABQ-48: NSC D-763307) and the corresponding 7-benzyl-3- nitrobenzimidazo[ Read More

In the present investigation an attempt was made to screen actinomycetes for the therapeutic lead. Marine soil samples were collected from Chennai region, Tamil Nadu, India for the isolation of actinomycetes, about 6 actinobacterial colonies were isolated and screened for its bioactive potential by cross streak method. Among the six isolates screened, one isolate named VITSD1showed potent bioactivity. The molecular Read More