Skip to content
2000
Volume 19, Issue 3
  • ISSN: 1573-4072
  • E-ISSN: 1875-6646

Abstract

Neem (Azadirachta indica), a Meliaceae family member, is a rapidly growing tropical evergreen tree with a thick, branching trunk. It has been used for hundreds of years in traditional Indian medicine as a home cure against numerous human illnesses in the Indian and African continents. Different components of the plant, including the flowers, leaves, seeds, and bark, have been used to treat both acute and chronic human illnesses, as well as an insecticide, antibiotic, larvicidal, antimalarial, antibacterial, antiviral, and spermicidal. The plant's anticancer qualities have been extensively researched in terms of its preventative, protective, tumor-suppressive, immunomodulatory, and apoptotic actions against different cancers and their molecular processes. Triple-negative breast cancer (TNBC), which lacks the expression of progesterone and estrogen receptors, has a dismal prognosis and no viable therapeutic options. Gedunin compound isolated from Azadirachta indica's seed oil shows potential anticancer effect against triple-negative breast cancer (TNBC) cancer cells, which acts as heat shock protein 90 (Hsp90) inhibitor.

Loading

Article metrics loading...

/content/journals/cbc/10.2174/1573407218666220818110059
2023-03-01
2025-07-04
Loading full text...

Full text loading...

/content/journals/cbc/10.2174/1573407218666220818110059
Loading

  • Article Type:
    Review Article
Keyword(s): anticancer; Azadirachta indica; heat shock protein; inhibitor; Neem; TNBC
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test