Skip to content
2000
Volume 21, Issue 3
  • ISSN: 1573-4072
  • E-ISSN: 1875-6646

Abstract

Psoriasis is a long-term inflammatory skin condition that is caused by a typical proliferating keratinocytes that emerge as substantial scaly, red and fragile patches. Although in current therapy, conventional treatments usually involve topical corticosteroids, immunosuppressants, and phototherapy, these therapies have restrictions and undesirable consequences. Nanotechnology provides significant novel opportunities for enhancing drug distribution and clinical effectiveness. The study focuses on a novel herb-based nanotechnological technique in treating psoriasis. The application of nanotechnology in herbal products has the potential to enhance the bioavailability, stability, and controlled administration of active substances, hence maximizing therapeutic outcomes and minimizing undesirable effects. Niosomes, liposomes, and nanoemulsions facilitate the penetration of herbal extracts such as aloe vera, turmeric, neem, and chamomile into the skin layers, along with providing anti-inflammatory, antioxidant, and immunomodulatory effects. This novel approach has the potential to strengthen therapeutic results, reduce adverse effects, and increase patient compliance. Also, the application of herbal extracts is consistent with the growing trend of natural and alternative healthcare treatments.

Loading

Article metrics loading...

/content/journals/cbc/10.2174/0115734072312903240523060831
2024-05-30
2025-06-22
Loading full text...

Full text loading...

References

  1. SindrilaruA. FilipA. KochanekS.K. CrisanD. How can nanoparticle‐based technologies revolutionize the topical therapy in psoriasis?Exp. Dermatol.202029111097110310.1111/exd.14149 32657487
    [Google Scholar]
  2. Di MeglioP. VillanovaF. NestleF.O. Psoriasis.Cold Spring Harb. Perspect. Med.201448a01535410.1101/cshperspect.a015354 25085957
    [Google Scholar]
  3. ZhongL. LuoN. ZhongX. XuT. HaoP. The immunoregulatory effects of natural products on psoriasis via its action on Th17 cells versus regulatory T cells balance.Int. Immunopharmacol.2022110May10903210.1016/j.intimp.2022.109032 35810491
    [Google Scholar]
  4. Mascarenhas-MeloF. CarvalhoA. GonçalvesM.B.S. Paiva-SantosA.C. VeigaF. Nanocarriers for the topical treatment of psoriasis - Pathophysiology, conventional treatments, nanotechnology, regulatory and toxicology.Eur. J. Pharm. Biopharm.202217649510710.1016/j.ejpb.2022.05.012 35605927
    [Google Scholar]
  5. JoH.G. KimH. BaekE. LeeD. HwangJ.H. Efficacy and key materials of east asian herbal medicine combined with conventional medicine on inflammatory skin lesion in patients with Psoriasis Vulgaris: A meta-analysis, integrated data mining, and network pharmacology.Pharmaceuticals2023168116010.3390/ph16081160 37631075
    [Google Scholar]
  6. RaharjaA. MahilS.K. BarkerJ.N. Psoriasis: A brief overview.Clin. Med.202121317017310.7861/clinmed.2021‑0257 34001566
    [Google Scholar]
  7. SongQ. ChenY. MaJ. ZhouW. SongJ. WuC. LiuJ. Metabolomics reveals molecular signatures for psoriasis biomarkers and drug targets discovery.Clin. Cosmet. Investig. Dermatol.202316113181319110.2147/CCID.S433280 37941849
    [Google Scholar]
  8. YanB.X. ChenX.Y. YeL.R. ChenJ.Q. ZhengM. ManX.Y. Cutaneous and systemic psoriasis: Classifications and classification for the distinction.Front. Med.20218October64940810.3389/fmed.2021.649408 34722555
    [Google Scholar]
  9. Kelly-SellM. GudjonssonJ.E. Overview of psoriasis. Therapy for Severe Psoriasis.Wiley201611510.1016/B978‑0‑323‑44797‑3.00001‑3
    [Google Scholar]
  10. BiswasroyP. PradhanD. KarB. GhoshG. RathG. Recent advancement in topical nanocarriers for the treatment of psoriasis.AAPS PharmSciTech202122516410.1208/s12249‑021‑02057‑z 34041632
    [Google Scholar]
  11. FernandesA. RodriguesP.M. PintadoM. TavariaF.K. A systematic review of natural products for skin applications: Targeting inflammation, wound healing, and photo-aging.Phytomedicine202311515482410.1016/j.phymed.2023.154824 37119762
    [Google Scholar]
  12. Zakki UddinS.K. PandaN. AnjanaG.V. KathiravanM.K. A review on phytoconstituents for psoriasis.J. Nat. Rem.202323111210.18311/jnr/2023/32121
    [Google Scholar]
  13. ZhouX. ChenY. CuiL. ShiY. GuoC. Advances in the pathogenesis of psoriasis: From keratinocyte perspective.Cell Death Dis.20221318110.1038/s41419‑022‑04523‑3 35075118
    [Google Scholar]
  14. GisondiP. BellinatoF. GirolomoniG. AlbanesiC. Pathogenesis of chronic plaque psoriasis and its intersection with cardio-metabolic comorbidities.Front. Pharmacol.202011February11710.3389/fphar.2020.00117 32161545
    [Google Scholar]
  15. DongC. LinL. DuJ. Characteristics and sources of tissue-resident memory T cells in psoriasis relapse.Curr. Res. Immunol.20234September10006710.1016/j.crimmu.2023.100067 37701270
    [Google Scholar]
  16. FaiziN. KazmiS. Universal health coverage - There is more to it than meets the eye.J. Family Med. Prim. Care20176116917010.4103/jfmpc.jfmpc_13_17 29026777
    [Google Scholar]
  17. ZhuB. JingM. YuQ. GeX. YuanF. ShiL. Treatments in psoriasis: From standard pharmacotherapy to nanotechnology therapy.Postepy Dermatol. Alergol.202239346047110.5114/ada.2021.108445 35950130
    [Google Scholar]
  18. RamezS.A. Novel methotrexate soft nanocarrier/fractional erbium YAG laser combination for clinical treatment of plaque psoriasis.Artif. Cells Nanomed. Biotechnol.201846S1996100210.1080/21691401.2018.1440236
    [Google Scholar]
  19. RendonA. SchäkelK. Psoriasis pathogenesis and treatment.Int. J. Mol. Sci.2019206147510.3390/ijms20061475 30909615
    [Google Scholar]
  20. RuggieroA. PortarapilloA. MegnaM. PatrunoC. NapolitanoM. Management strategies for pediatric moderate-to-severe plaque psoriasis: Spotlight on biologics.Pediatric Health Med. Ther.20231443545110.2147/PHMT.S389108
    [Google Scholar]
  21. DiotalleviF. SimonettiO. RizzettoG. MolinelliE. RadiG. OffidaniA. Biological treatments for pediatric psoriasis: State of the art and future perspectives.Int. J. Mol. Sci.202223191112810.3390/ijms231911128 36232430
    [Google Scholar]
  22. LeeH.J. KimM. Challenges and future trends in the treatment of psoriasis.Int. J. Mol. Sci.202324171331310.3390/ijms241713313 37686119
    [Google Scholar]
  23. PattapuS. MeejuriU. Treatment of psoriasis using herbal plants.Int. J. Res. Eng. Sci. Manag.2019211
    [Google Scholar]
  24. ThatiparthiA. MartinA. LiuJ. EgebergA. WuJ.J. Biologic treatment algorithms for moderate-to-severe psoriasis with comorbid conditions and special populations: A review.Am. J. Clin. Dermatol.202122442544210.1007/s40257‑021‑00603‑w 33861409
    [Google Scholar]
  25. MicaliG. VerzìA.E. GiuffridaG. PanebiancoE. MusumeciM.L. LacarrubbaF. Inverse psoriasis: From diagnosis to current treatment options.Clin. Cosmet. Investig. Dermatol.20201295395910.2147/CCID.S189000 32099435
    [Google Scholar]
  26. BellinatoF. GisondiP. GirolomoniG. Latest advances for the treatment of chronic plaque psoriasis with biologics and oral small molecules.Biologics20211524725310.2147/BTT.S290309 34239295
    [Google Scholar]
  27. DrakosA. VenderR. A review of the clinical trial landscape in psoriasis: An update for clinicians.Dermatol. Ther.202212122715273010.1007/s13555‑022‑00840‑9 36319883
    [Google Scholar]
  28. KuchekarA.B. PujariR.R. KuchekarS.B. DholeS.N. Psoriasis: A comprehensive review.Int. J. of Pharm. & Life Sci.201126857877
    [Google Scholar]
  29. AhmadM.Z. MohammedA.A. AlgahtaniM.S. MishraA. AhmadJ. Nanoscale topical pharmacotherapy in management of psoriasis: Contemporary research and scope.J. Funct. Biomater.20221411910.3390/jfb14010019 36662067
    [Google Scholar]
  30. BhalchandraK. LuqmanS. Alternative medicine for psoriasis - Natural herbal ayurvedic treatment - A review.Int. J. Ayurvedic Herb. Mach.2012141
    [Google Scholar]
  31. MengS. LinZ. WangY. WangZ. LiP. ZhengY. Psoriasis therapy by Chinese medicine and modern agents.Chin. Med.20181311610.1186/s13020‑018‑0174‑0 29588654
    [Google Scholar]
  32. GarbiczJ. CałyniukB. GórskiM. BuczkowskaM. PiecuchM. KulikA. RozentrytP. Nutritional therapy in persons suffering from psoriasis.Nutrients202114111910.3390/nu14010119 35010995
    [Google Scholar]
  33. MaheshwariN. MaheshwariN. MishraD.K. GoyalA. Phytotherapeutic potential of natural herbal medicines for management of psoriasis: Current status.Pharmacognosy Res.2022151425510.5530/097484900261
    [Google Scholar]
  34. GuptaS. GuptaJ. AnandA. OjhaS. Review on nanogel/emulgel formulations of traditional medicines.Biological Sciences202202326927810.55006/biolsciences.2022.2304
    [Google Scholar]
  35. KumarA. SinghG. Medicinal utility of some herbs for the treatment of psoriasis: An updated approach.Int. J. Botany Stud.202163308312
    [Google Scholar]
  36. BocaA.N. TataruA. BuzoianuA.D. PincelliC. SocaciuC. Pharmacological benefits of herbal formulations in the management of psoriasis vulgaris.Not. Bot. Horti Agrobot. Cluj-Napoca20144211810.15835/nbha4219484
    [Google Scholar]
  37. GaikwadR.G. ShindeA.J. HajareA.A. Herbal treatment for management of psoriasis: An overview.Res J. Pharm. Technol.20221531385139210.52711/0974‑360X.2022.00231
    [Google Scholar]
  38. SinghK.K. TripathyS. Natural treatment alternative for psoriasis: A review on herbal resources.J. Appl. Pharm. Sci.201441111412110.7324/JAPS.2014.41120
    [Google Scholar]
  39. BhamreN.S. BhamareS.B. Herbal and nanotechnology in the treatment of Psoriasis202293455467
    [Google Scholar]
  40. PerlakN.M. SzpadelK. JabłońskaI. PizonM. WoźniakM. Promising strategies in plant-derived treatments of psoriasis-update of in vitro, in vivo, and clinical trials studies.Molecules202227359110.3390/molecules27030591 35163855
    [Google Scholar]
  41. HillH. AndersonN. JacobS.E. Herbals in the holistic treatment of psoriasis.Dermatology20164611990199710.2147/AMEP.S69761
    [Google Scholar]
  42. MedicineH. Nanotechnology in management of psoriasis: A focus on herbal therapy.Indo Amer. J. Pharmaceut. Res.201770174177426
    [Google Scholar]
  43. ChandaneA.Y. KulkarniA.P. ShastriA.R. An overview of promising herbal medicines for treatment of psoriasis.Int. J. Pharm. Sci. Res.202112272774310.13040/IJPSR.0975‑8232.12(2).727‑43
    [Google Scholar]
  44. GendrischF. HaarhausB. KriegerN. QuirinK.W. SchemppC.M. WölfleU. The effect of herbal medicinal products on psoriasis-like keratinocytes.Biomolecules202111337110.3390/biom11030371 33801280
    [Google Scholar]
  45. TamboliF.A. KokateP.C. ShaikhA.R. ShindeA.J. NamdeoA. AlaskarK. Important medicinal plants for management of psoriasis.Ind. J. Pharm. Pharmacol.20229212212710.18231/j.ijpp.2022.021
    [Google Scholar]
  46. YadavN. AggarwalR. TarghotraM. SahooP.K. ChauhanM.K. Natural and nanotechnology based treatment: An alternative approach to psoriasis.Curr. Nanomed.2021111213910.2174/2468187310999201022192318
    [Google Scholar]
  47. ArticleR. Treatment for psoriasis - A herbal approach.Int. J. Pharm. Sci. Rev. Res.20195515860
    [Google Scholar]
  48. JournalT. JournalL.S. Herbal drugs in the treatment of psoriasis.Trop. J.202310128795
    [Google Scholar]
  49. DabholkarN. RapalliV.K. SinghviG. Potential herbal constituents for psoriasis treatment as protective and effective therapy.Phytother. Res.20213552429244410.1002/ptr.6973 33277958
    [Google Scholar]
  50. ElkhawagaO.Y. ElletyM.M. MoftyS.O. GhanemM.S. MohamedA.O. Review of natural compounds for potential psoriasis treatment.Inflammopharmacology20233131183119810.1007/s10787‑023‑01178‑0 36995575
    [Google Scholar]
  51. FereigS.A. El-ZaafaranyG.M. ArafaM.G. MottalebA.M.M.A. Tackling the various classes of nano-therapeutics employed in topical therapy of psoriasis.Drug Deliv.202027166268010.1080/10717544.2020.1754527 32393082
    [Google Scholar]
  52. XieJ. HuangS. HuangH. DengX. YueP. LinJ. YangM. HanL. ZhangD. Advances in the application of natural products and the novel drug delivery systems for psoriasis.Front. Pharmacol.202112April64495210.3389/fphar.2021.644952 33967781
    [Google Scholar]
  53. MiereF. Preparation and characterization of two different liposomal formulations with bioactive natural extract for multiple applications.Processes20219343210.3390/pr9030432
    [Google Scholar]
  54. MoghimipourE. AghelN. MahmoudabadiA.Z. RamezaniZ. HandaliS. Preparation and characterization of liposomes containing essential oil of Eucalyptus camaldulensis leaf.Jundishapur J. Nat. Pharm. Prod.20127311712210.5812/jjnpp.5261 24624167
    [Google Scholar]
  55. KumariJ. ChaurasiaL. Formulation and evaluation of curcumin loaded nanoliposome on brain targeted.Curr. Res. Pharmaceut. Sci.2021111314310.24092/CRPS.2021.110104
    [Google Scholar]
  56. ThirumalD. SindhuR.K. GoyalS. SehgalA. KumarA. BabuM.A. KumarP. Pathology and treatment of psoriasis using nanoformulations.Biomedicines2023116158910.3390/biomedicines11061589 37371684
    [Google Scholar]
  57. Sci-techL. EngineeringI. 张 令甜 1, 敖飞翔 2, 涂传 清2:2020
    [Google Scholar]
  58. VohraP. VarekarS. ShahV. Nano-transferosomes of aloe-vera and vitamin-E for management of psoriasis. An Archetype.Herb. Drug Technol.2023912876882
    [Google Scholar]
  59. NikamV. ManiyarS. Formulation development and evaluation of niosomal gel of collective anti-fungal agents.Asian J. Pharm. Clin. Res.2021152647410.22159/ajpcr.2022.v15i2.43484
    [Google Scholar]
  60. GhummanS.A. IjazA. NoreenS. AslamA. KausarR. IrfanA. LatifS. ShazlyG.A. ShahP.A. RanaM. AslamA. AltafM. MojzychK.K. Bin JardanY.A. Formulation and characterization of curcumin niosomes: Antioxidant and cytotoxicity studies.Pharmaceuticals20231610140610.3390/ph16101406 37895877
    [Google Scholar]
  61. RaafatK.M. El-ZahabyS.A. Niosomes of active Fumaria officinalis phytochemicals: Antidiabetic, antineuropathic, anti-inflammatory, and possible mechanisms of action.Chin. Med.20201514010.1186/s13020‑020‑00321‑1 32377229
    [Google Scholar]
  62. GuoJ.W. ChengY.P. LiuC.Y. ThongH.Y. HuangC.J. LoY. WuC.Y. JeeS.H. Salvianolic acid b in microemulsion formulation provided sufficient hydration for dry skin and ameliorated the severity of imiquimod-induced psoriasis-like dermatitis in mice.Pharmaceutics202012545710.3390/pharmaceutics12050457 32429542
    [Google Scholar]
  63. Role of essential oils in the preparation of topical antimicrobial micro emulsion.RE:view2020711368376
    [Google Scholar]
  64. AliF. NehaK. SharmaK. KhasimbiS. ChauhanG. Nanotechnology-based medicinal products and patents: A promising way to treat psoriasis.Curr. Drug Deliv.202219558759910.2174/1567201819666220126163943 35081890
    [Google Scholar]
  65. SahuR. SharmaN.K. Formulation development and characterization of nigella sativa linn loaded ethosomes and transethosomes gel for the treatment of psoriasis : A comparative assessment.Eur. Chem. Bull.202312511131125
    [Google Scholar]
  66. BhiseK. KhanS. MullaG. Topical anti-psoriatic nanoparticulate drug delivery system.Int J. Appl. Pharmaceut.2020122768510.22159/ijap.2020v12i2.36536
    [Google Scholar]
  67. DigheS.B. RanawatM.S. RautD.N. JasudS.P. Nanotechnology approaches to enhance the therapeutic potential of Bacosides and Bacoside rich fractions targeting the brain.J. Med. Pharmaceut. Allied Sci.20222143149
    [Google Scholar]
  68. SerdaM. quercitin; ,2013
    [Google Scholar]
  69. VincentN. DR.D. BnV.H. Progress in psoriasis therapy via novel drug delivery systems.Dermatol. Rep.201461545110.4081/dr.2014.5451 25386329
    [Google Scholar]
  70. NingsihI.Y. FaradisaH. CahyaniM.D. RosyidiV.A. HidayatM.A. The formulation of ginger oil nanoemulsions of three varieties of ginger (Zingiber officinale Rosc.) as natural antioxidant.J. Res. Pharm.202024691492410.35333/JRP.2020.251
    [Google Scholar]
  71. AlshehriS. Formulation of piperine-loaded nanoemulsion: In vitro characterization, ex vivo evaluation, and cell viability assessment.ACS Omega.2023825224062241310.1021/acsomega.2c08187
    [Google Scholar]
  72. BajerskiL. MichelsL.R. ColoméL.M. BenderE.A. FreddoR.J. BruxelF. HaasS.E. The use of Brazilian vegetable oils in nanoemulsions: An update on preparation and biological applications.Braz. J. Pharm. Sci.201652334736310.1590/s1984‑82502016000300001
    [Google Scholar]
  73. KaurJ. AnwerK. SartajA. PandaB.P. AliA. ZafarA. KumarV. GilaniS.J. KalaC. TaleuzzamanM. ZnO nanoparticles of Rubia cordifolia extract formulation developed and optimized with QbD application, considering ex vivo skin permeation, antimicrobial and antioxidant properties.Molecules20222741450
    [Google Scholar]
  74. PetitR.G. CanoA. OrtizA. EspinaM. PratJ. MuñozM. SeverinoP. SoutoE.B. GarcíaM.L. PujolM. LópezS.E. Psoriasis: From pathogenesis to pharmacological and nano-technological-based therapeutics.Int. J. Mol. Sci.2021229498310.3390/ijms22094983 34067151
    [Google Scholar]
  75. PengT. Microneedles for enhanced topical treatment of skin disorders: Applications, challenges, and prospects.Engineering2023301017018910.1016/j.eng.2023.05.009
    [Google Scholar]
  76. DamiriF. KommineniN. EbhodagheS.O. BulusuR. JyothiV.G.S.S. SayedA.A. AwajiA.A. GermoushM.O. Al-malkyH.S. NasrullahM.Z. RahmanM.H. Abdel-DaimM.M. BerradaM. Microneedle-based natural polysaccharide for drug delivery systems (DDS): Progress and challenges.Pharmaceuticals202215219010.3390/ph15020190 35215302
    [Google Scholar]
  77. VasowalaT. GharatS. MhaseM. MominM. Advances in hydrogels based cutaneous drug delivery system for management of psoriasis.Eur. Polym. J.2024202211263010.1016/j.eurpolymj.2023.112630
    [Google Scholar]
  78. NawazA. FaridA. SafdarM. LatifM.S. GhazanfarS. AkhtarN. Al JaouniS.K. SelimS. KhanM.W. Formulation development and ex-vivo permeability of curcumin hydrogels under the influence of natural chemical enhancers.Gels20228638410.3390/gels8060384 35735728
    [Google Scholar]
  79. EspositoL. BarbosaA.I. MonizT. Costa LimaS. CostaP. CeliaC. ReisS. Design and characterization of sodium alginate and poly(Vinyl) alcohol hydrogels for enhanced skin delivery of quercetin.Pharmaceutics20201212114910.3390/pharmaceutics12121149 33260825
    [Google Scholar]
  80. MazayenZ.M. GhoneimA.M. ElbatanonyR.S. BasaliousE.B. BendasE.R. Pharmaceutical nanotechnology: From the bench to the market.Futur. J. Pharmaceut. Sci.2022811210.1186/s43094‑022‑00400‑0 35071609
    [Google Scholar]
  81. AlimohammadiZ. ZamansaniA. AbreshtehA. EdalaatM. EbrahimiZ. Formulation and in vitro evaluation of quercetin loaded carbon nanotubes for cancer targeting. Int. Res. J. Eng. Technol;202310962967
    [Google Scholar]
  82. ZhangM. ChengJ. HuJ. LuoJ. ZhangY. LuF. KongH. QuH. ZhaoY. Green phellodendri chinensis cortex-based carbon dots for ameliorating imiquimod-induced psoriasis-like inflammation in mice.J. Nanobiotechnology202119110510.1186/s12951‑021‑00847‑y 33858431
    [Google Scholar]
  83. WollinaU. TirantM. VojvodicA. LottiT. Treatment of psoriasis: Novel approaches to topical delivery.Open Access Maced. J. Med. Sci.20197183018302510.3889/oamjms.2019.414 31850114
    [Google Scholar]
  84. TomarY. PanditN. PriyaS. SinghviG. Evolving trends in nanofibers for topical delivery of therapeutics in skin disorders.ACS Omega2023821183401835710.1021/acsomega.3c00924 37273582
    [Google Scholar]
  85. GüzelE.İ. AbdoL. YaparA.E. EsentürkE. BüyükkayhanD. K SindhuR. An overview of nanofiber applications for development of phytopharmaceuticals.Bezmialem Sci.202210566667310.14235/bas.galenos.2022.30502
    [Google Scholar]
  86. GargT. RathG. GoyalA.K. Nanotechnological approaches for the effective management of psoriasis.Artif. Cells Nanomed. Biotechnol.20164461374138210.3109/21691401.2015.1037885 25919064
    [Google Scholar]
  87. ChandrasekaranK. Development of combination herbal nano-encapsulated healthcare apparel for psoriasis.Int. J. Mechan. Eng.202163311318
    [Google Scholar]
  88. monem, A.R.; leithy, E.E.S.; Eldin, A.A.A.; Rashid, A.R.S. Curcumin/fusidic acid bitherapy loaded mixed micellar nanogel for acne vulgaris treatment: In vitro and in vivo studies.AAPS PharmSciTech202324718210.1208/s12249‑023‑02641‑5 37697137
    [Google Scholar]
/content/journals/cbc/10.2174/0115734072312903240523060831
Loading
/content/journals/cbc/10.2174/0115734072312903240523060831
Loading

Data & Media loading...


  • Article Type:
    Review Article
Keyword(s): corticosteroids; keratinocytes; Medicinal plants; nanoparticle; psoriasis; skin
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test