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Volume 21, Issue 2
  • ISSN: 1573-4072
  • E-ISSN: 1875-6646

Abstract

Shankhpushpi (), also called Choisy (), is a longstanding shrub also known by the names Sieb. as well as Forsk and it’s employed as a traditional people’s remedy for a number of illnesses such as memory enhancement in Ayurveda and Conventional Chinese Medicine system. It is primarily utilized as a memory enhancer and brain stimulant for the treatment of central nervous diseases like stress, depression, and sleeplessness. Traditional Indian medications are used. Anxiolytic, neurological (Alzheimer's, Huntington's, Epilepsy, but also Depressant) antioxidants, analgesics, immunomodulatory, antibacterial, antihyperlipidemic, and cardioprotective actions are just a few of the medicinal qualities of this herb that have been linked to them in historical publications. Therefore, identifying and scientifically validating herbal remedies helps advance Ayurvedic/ Unani studies. Various biological phytoconstituents, including the alkaloids (convolamine), flavonoids (kaempferol), and polyphenolic compounds (scopoletin, sitosterol, and ceryl alcohol), have been linked to the therapeutic benefits of this botanical. Several active substances, such as scopoletin, kaempferol phytosterol, as well as -sitosterol, which was extracted from flying sections of , have been demonstrated to work as GABA agonists that might explain the antianxiety and CNS depressant properties of shankhpushpi. To compile data for this article, a Systematic Literature Review on was conducted.

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References

  1. GarcinB. Motor functional neurological disorders: An update.Rev. Neurol.2018174420321110.1016/j.neurol.2017.11.003 29609961
     [Google Scholar]
  2. SharmaR. SinglaR.K. BanerjeeS. SinhaB. ShenB. SharmaR. Role of Shankhpushpi (Convolvulus pluricaulis) in neurological disorders: An umbrella review covering evidence from ethnopharmacology to clinical studies.Neurosci. Biobehav. Rev.202214010479510.1016/j.neubiorev.2022.104795 35878793
     [Google Scholar]
  3. PringsheimT. JetteN. FrolkisA. SteevesT.D.L. The prevalence of Parkinson’s disease: A systematic review and meta‐analysis.Mov. Disord.201429131583159010.1002/mds.25945 24976103
     [Google Scholar]
  4. RajuT.R. MohanakumarK.P. Neural functions of the aging brain: Daily living, developmental and geriatric disabilities.J. Chem. Neuroanat.2019951510.1016/j.jchemneu.2018.12.004 30635101
     [Google Scholar]
  5. FeiginV.L. NicholsE. AlamT. BannickM.S. BeghiE. BlakeN. CulpepperW.J. DorseyE.R. ElbazA. EllenbogenR.G. FisherJ.L. FitzmauriceC. GiussaniG. GlennieL. JamesS.L. JohnsonC.O. KassebaumN.J. LogroscinoG. MarinB. VenningM.W.C. NguyenM. AsensoO.R. PatelA.P. PiccininniM. RothG.A. SteinerT.J. StovnerL.J. SzoekeC.E.I. TheadomA. VollsetS.E. WallinM.T. WrightC. ZuntJ.R. AbbasiN. Abd-AllahF. AbdelalimA. AbdollahpourI. AboyansV. AbrahaH.N. AcharyaD. AdamuA.A. AdebayoO.M. AdeoyeA.M. AdsuarJ.C. AfaridehM. AgrawalS. AhmadiA. AhmedM.B. AichourA.N. AichourI. AichourM.T.E. AkinyemiR.O. AkseerN. Al-EyadhyA. Al-Shahi SalmanR. AlahdabF. AleneK.A. AljunidS.M. AltirkawiK. GuzmanA.N. AnberN.H. AntonioC.A.T. ArablooJ. AremuO. ÄrnlövJ. AsayeshH. AsgharR.J. AtalayH.T. AwasthiA. QuintanillaA.B.P. AyukT.B. BadawiA. BanachM. BanoubJ.A.M. BarbozaM.A. ColloB.S.L. BärnighausenT.W. BauneB.T. BediN. BehzadifarM. BehzadifarM. BéjotY. BekeleB.B. BelachewA.B. BennettD.A. BensenorI.M. BerhaneA. BeuranM. BhattacharyyaK. BhuttaZ.A. BiadgoB. BijaniA. BililignN. Bin SayeedM.S. BlazesC.K. BrayneC. ButtZ.A. NonatoC.I.R. BritoC.C. CarM. CárdenasR. CarreroJ.J. CarvalhoF. OrjuelaC.C.A. CastroF. LópezC.F. CerinE. ChaiahY. ChangJ-C. ChatziralliI. ChiangP.P-C. ChristensenH. ChristopherD.J. CooperC. CortesiP.A. CostaV.M. CriquiM.H. CroweC.S. DamascenoA.A.M. DaryaniA. De la GóngoraC.V. De la HozF.P. De LeoD. DemozG.T. DeribeK. DharmaratneS.D. DiazD. DinberuM.T. DjalaliniaS. DokuD.T. DubeyM. DubljaninE. DukenE.E. EdvardssonD. El-KhatibZ. EndresM. EndriesA.Y. EskandariehS. EsteghamatiA. EsteghamatiS. FarhadiF. FaroA. FarzadfarF. FarzaeiM.H. FatimaB. FereshtehnejadS-M. FernandesE. FeyissaG.T. FilipI. FischerF. FukumotoT. GanjiM. GankpeF.G. Garcia-GordilloM.A. GebreA.K. GebremichaelT.G. GelawB.K. GeleijnseJ.M. GeremewD. GezaeK.E. KasmanG.M. GideyM.Y. GillP.S. GillT.K. GirmaE.T. GnedovskayaE.V. GoulartA.C. GradaA. GrossoG. GuoY. GuptaR. GuptaR. HaagsmaJ.A. HagosT.B. Haj-MirzaianA. Haj-MirzaianA. HamadehR.R. HamidiS. HankeyG.J. HaoY. HaroJ.M. HassankhaniH. HassenH.Y. HavmoellerR. HayS.I. HegazyM.I. HeidariB. HenokA. HeydarpourF. HoangC.L. HoleM.K. Homaie RadE. HosseiniS.M. HuG. IgumborE.U. IlesanmiO.S. IrvaniS.S.N. IslamS.M.S. JakovljevicM. JavanbakhtM. JhaR.P. JobanputraY.B. JonasJ.B. JozwiakJ.J. JürissonM. KahsayA. KalaniR. KalkondeY. KamilT.A. KanchanT. KaramiM. KarchA. KarimiN. KasaeianA. KassaT.D. KassaZ.Y. KaulA. KefaleA.T. KeiyoroP.N. KhaderY.S. KhafaieM.A. KhalilI.A. KhanE.A. KhangY-H. KhazaieH. KiadaliriA.A. KiirithioD.N. KimA.S. KimD. KimY-E. KimY.J. KisaA. KokuboY. KoyanagiA. KrishnamurthiR.V. KuateDefo B.; Kucuk Bicer, B.; Kumar, M.; Lacey, B.; Lafranconi, A.; Lansingh, V.C.; Latifi, A.; Leshargie, C.T.; Li, S.; Liao, Y.; Linn, S.; Lo, W.D.; Lopez, J.C.F.; Lorkowski, S.; Lotufo, P.A.; Lucas, R.M.; Lunevicius, R.; Mackay, M.T.; Mahotra, N.B.; Majdan, M.; Majdzadeh, R.; Majeed, A.; Malekzadeh, R.; Malta, D.C.; Manafi, N.; Mansournia, M.A.; Mantovani, L.G.; März, W.; Mashamba-Thompson, T.P.; Massenburg, B.B.; Mate, K.K.V.; McAlinden, C.; McGrath, J.J.; Mehta, V.; Meier, T.; Meles, H.G.; Melese, A.; Memiah, P.T.N.; Memish, Z.A.; Mendoza, W.; Mengistu, D.T.; Mengistu, G.; Meretoja, A.; Meretoja, T.J.; Mestrovic, T.; Miazgowski, B.; Miazgowski, T.; Miller, T.R.; Mini, G.K.; Mirrakhimov, E.M.; Moazen, B.; Mohajer, B.; Mohammad Gholi Mezerji, N.; Mohammadi, M.; Mohammadi-Khanaposhtani, M.; Mohammadibakhsh, R.; Mohammadnia-Afrouzi, M.; Mohammed, S.; Mohebi, F.; Mokdad, A.H.; Monasta, L.; Mondello, S.; Moodley, Y.; Moosazadeh, M.; Moradi, G.; Moradi-Lakeh, M.; Moradinazar, M.; Moraga, P.; Velásquez, M.I.; Morrison, S.D.; Mousavi, S.M.; Muhammed, O.S.; Muruet, W.; Musa, K.I.; Mustafa, G.; Naderi, M.; Nagel, G.; Naheed, A.; Naik, G.; Najafi, F.; Nangia, V.; Negoi, I.; Negoi, R.I.; Newton, C.R.J.; Ngunjiri, J.W.; Nguyen, C.T.; Nguyen, L.H.; Ningrum, D.N.A.; Nirayo, Y.L.; Nixon, M.R.; Norrving, B.; Noubiap, J.J.; Shiadeh, N.M.; Nyasulu, P.S.; Ogah, O.S.; Oh, I-H.; Olagunju, A.T.; Olagunju, T.O.; Olivares, P.R.; Onwujekwe, O.E.; Oren, E.; Owolabi, M.O.; Pa, M.; Pakpour, A.H.; Pan, W-H.; Panda-Jonas, S.; Pandian, J.D.; Patel, S.K.; Pereira, D.M.; Petzold, M.; Pillay, J.D.; Piradov, M.A.; Polanczyk, G.V.; Polinder, S.; Postma, M.J.; Poulton, R.; Poustchi, H.; Prakash, S.; Prakash, V.; Qorbani, M.; Radfar, A.; Rafay, A.; Rafiei, A.; Rahim, F.; Movaghar, R.V.; Rahman, M.; Rahman, M.H.U.; Rahman, M.A.; Rajati, F.; Ram, U.; Ranta, A.; Rawaf, D.L.; Rawaf, S.; Reinig, N.; Reis, C.; Renzaho, A.M.N.; Resnikoff, S.; Rezaeian, S.; Rezai, M.S.; Rios González, C.M.; Roberts, N.L.S.; Roever, L.; Ronfani, L.; Roro, E.M.; Roshandel, G.; Rostami, A.; Sabbagh, P.; Sacco, R.L.; Sachdev, P.S.; Saddik, B.; Safari, H.; Faramani, S.R.; Safi, S.; Safiri, S.; Sagar, R.; Sahathevan, R.; Sahebkar, A.; Sahraian, M.A.; Salamati, P.; Zahabi, S.S.; Salimi, Y.; Samy, A.M.; Sanabria, J.; Santos, I.S.; Milicevic, S.M.M.; Sarrafzadegan, N.; Sartorius, B.; Sarvi, S.; Sathian, B.; Satpathy, M.; Sawant, A.R.; Sawhney, M.; Schneider, I.J.C.; Schöttker, B.; Schwebel, D.C.; Seedat, S.; Sepanlou, S.G.; Shabaninejad, H.; Shafieesabet, A.; Shaikh, M.A.; Shakir, R.A.; Beyranvand, S.M.; Shamsizadeh, M.; Sharif, M.; Alhoseini, S.M.; She, J.; Sheikh, A.; Sheth, K.N.; Shigematsu, M.; Shiri, R.; Shirkoohi, R.; Shiue, I.; Siabani, S.; Siddiqi, T.J.; Sigfusdottir, I.D.; Sigurvinsdottir, R.; Silberberg, D.H.; Silva, J.P.; Silveira, D.G.A.; Singh, J.A.; Sinha, D.N.; Skiadaresi, E.; Smith, M.; Sobaih, B.H.; Sobhani, S.; Soofi, M.; Soyiri, I.N.; Sposato, L.A.; Stein, D.J.; Stein, M.B.; Stokes, M.A.; Sufiyan, M.B.; Sykes, B.L.; Sylaja, P.N.; Tabarés-Seisdedos, R.; Te Ao, B.J.; Banihashemi, T.A.; Temsah, M-H.; Temsah, O.; Thakur, J.S.; Thrift, A.G.; Topor-Madry, R.; Girbés, T.M.; Palone, T.M.R.; Tran, B.X.; Tran, K.B.; Truelsen, T.C.; Tsadik, A.G.; Tudor Car, L.; Ukwaja, K.N.; Ullah, I.; Usman, M.S.; Uthman, O.A.; Valdez, P.R.; Vasankari, T.J.; Vasanthan, R.; Veisani, Y.; Venketasubramanian, N.; Violante, F.S.; Vlassov, V.; Vosoughi, K.; Vu, G.T.; Vujcic, I.S.; Wagnew, F.S.; Waheed, Y.; Wang, Y-P.; Weiderpass, E.; Weiss, J.; Whiteford, H.A.; Wijeratne, T.; Winkler, A.S.; Wiysonge, C.S.; Wolfe, C.D.A.; Xu, G.; Yadollahpour, A.; Yamada, T.; Yano, Y.; Yaseri, M.; Yatsuya, H.; Yimer, E.M.; Yip, P.; Yisma, E.; Yonemoto, N.; Yousefifard, M.; Yu, C.; Zaidi, Z.; Zaman, S.B.; Zamani, M.; Zandian, H.; Zare, Z.; Zhang, Y.; Zodpey, S.; Naghavi, M.; Murray, C.J.L.; Vos, T. Global, regional, and national burden of neurological disorders, 1990–2016: A systematic analysis for the Global Burden of Disease Study 2016.Lancet Neurol.201918545948010.1016/S1474‑4422(18)30499‑X 30879893
     [Google Scholar]
  6. JakobsenJ.C. GluudC. KirschI. Should antidepressants be used for major depressive disorder?BMJ Evid. Based Med.202025413013010.1136/bmjebm‑2019‑111238 31554608
     [Google Scholar]
  7. ZhuX.L. ChenJ.J. HanF. PanC. ZhuangT.T. CaiY.F. LuY.P. Novel antidepressant effects of Paeonol alleviate neuronal injury with concomitant alterations in BDNF, Rac1 and RhoA levels in chronic unpredictable mild stress rats.Psychopharmacology201823572177219110.1007/s00213‑018‑4915‑7 29752492
     [Google Scholar]
  8. EratneD. LoiS.M. FarrandS. KelsoW. VelakoulisD. LooiJ.C.L. Alzheimer’s disease: Clinical update on epidemiology, pathophysiology and diagnosis.Australas. Psychiatry201826434735710.1177/1039856218762308 29614878
     [Google Scholar]
  9. PaidiR.K. SarkarS. AmbareenN. BiswasS.C. Medha plus – a novel polyherbal formulation ameliorates cognitive behaviors and disease pathology in models of Alzheimer’s disease.Biomed. Pharmacother.202215111308610.1016/j.biopha.2022.113086 35617801
     [Google Scholar]
  10. De MirandaB.R. GoldmanS.M. MillerG.W. GreenamyreJ.T. DorseyE.R. Preventing parkinson’s disease: An environmental agenda.J. Parkinsons Dis.2022121456810.3233/JPD‑212922 34719434
     [Google Scholar]
  11. MarogianniC. SokratousM. DardiotisE. HadjigeorgiouG.M. BogdanosD. XiromerisiouG. Neurodegeneration and inflammation—An interesting interplay in parkinson’s disease.Int. J. Mol. Sci.20202122842110.3390/ijms21228421 33182554
     [Google Scholar]
  12. SinghA. TrevickS. The epidemiology of global epilepsy.Neurol. Clin.201634483784710.1016/j.ncl.2016.06.015 27719996
     [Google Scholar]
  13. SinghG. SanderJ.W. The global burden of epilepsy report: Implications for low- and middle-income countries.Epilepsy Behav.202010510694910.1016/j.yebeh.2020.106949 32088583
     [Google Scholar]
  14. DubeyS.K. SinghviG. KrishnaK.V. AgnihotriT. SahaR.N. GuptaG. Herbal medicines in neurodegenerative disorders: An evolutionary approach through novel drug delivery system.J. Environ. Pathol. Toxicol. Oncol.201837319920810.1615/JEnvironPatholToxicolOncol.2018027246 30317971
     [Google Scholar]
  15. TranS. MathonB. SauvainM.E. LerondJ. NavarroV. BielleF. Neuropathologie de l’épilepsie.Ann. Pathol.202040644746010.1016/j.annpat.2020.08.001 33092907
     [Google Scholar]
  16. ManfordM. Recent advances in epilepsy.J. Neurol.201726481811182410.1007/s00415‑017‑8394‑2 28120042
     [Google Scholar]
  17. AlbariqiM. EngelsmanS. EijkelkampN. HöppenerJ. Amyloid proteins and peripheral neuropathy.Cells202096155310.3390/cells9061553 32604774
     [Google Scholar]
  18. RahmanMM IslamF ParvezA AzadMAK AshrafGM Ullah, MF Citrus limon L. (lemon) seed extract shows neuromodulatory activity in an in vivo thiopental-sodium sleep model by reducing the sleep onset and enhancing the sleep duration.J Integr Neurosci202221104210.31083/j.jin2101042
     [Google Scholar]
  19. SloanG. SelvarajahD. TesfayeS. Pathogenesis, diagnosis and clinical management of diabetic sensorimotor peripheral neuropathy.Nat. Rev. Endocrinol.202117740042010.1038/s41574‑021‑00496‑z 34050323
     [Google Scholar]
  20. HalderS. AnandU. NandyS. OleksakP. QustiS. AlshammariE.M. El-Saber BatihaG. KoshyE.P. DeyA. Herbal drugs and natural bioactive products as potential therapeutics: A review on pro-cognitives and brain boosters perspectives.Saudi Pharm. J.202129887990710.1016/j.jsps.2021.07.003 34408548
     [Google Scholar]
  21. YinR. XueJ. TanY. FangC. HuC. YangQ. The positive role and mechanism of herbal medicine in parkinson’s disease.Oxid. Med. Cell. Longev.20212021992333110.1155/2021/9923331
     [Google Scholar]
  22. LiuW. GeT. PanZ. LengY. LvJ. LiB. The effects of herbal medicine on epilepsy.Oncotarget2017829483854839710.18632/oncotarget.16801 28423368
     [Google Scholar]
  23. KaurM. PrakashA. KaliaA.N. Neuroprotective potential of antioxidant potent fractions from Convolvulus pluricaulis Chois. in 3-nitropropionic acid challenged rats.Nutr. Neurosci.2016192707810.1179/1476830515Y.0000000022 25896328
     [Google Scholar]
  24. LeachM.J. PageA.T. Herbal medicine for insomnia: A systematic review and meta-analysis.Sleep Med. Rev.20152411210.1016/j.smrv.2014.12.003 25644982
     [Google Scholar]
  25. LiuL. LiuC. WangY. WangP. LiY. LiB. Herbal medicine for anxiety, depression and insomnia.Curr. Neuropharmacol.201513448149310.2174/1570159X1304150831122734 26412068
     [Google Scholar]
  26. SethiyaN. TrivediA. PatelM. MishraS.H. Comparative pharmacognostical investigation on four ethanobotanicals traditionally used as Shankhpushpi in India.J. Adv. Pharm. Technol. Res.20101438839510.4103/0110‑5558.76437 22247878
     [Google Scholar]
  27. AgarwaP. SharmaB. FatimaA. JainS.K. An update on ayurvedic herb Convolvulus pluricaulis Choisy.Asian Pac. J. Trop. Biomed.20144324525210.1016/S2221‑1691(14)60240‑9 25182446
     [Google Scholar]
  28. BorisK. OxanaK. Handbook of greener synthesis of nanomaterials and compounds.Elsevier202110.1016/C2019‑0‑04948‑5
     [Google Scholar]
  29. NahataA. PatilU.K. DixitV.K. Anxiolytic activity of Evolvulus alsinoides and Convulvulus pluricaulis in rodents.Pharm. Biol.200947544445110.1080/13880200902822596
     [Google Scholar]
  30. NahataA. PatilU.K. DixitV.K. Effect of Convulvulus pluricaulis Choisy. on learning behaviour and memory enhancement activity in rodents.Nat. Prod. Res.200822161472148210.1080/14786410802214199 19023811
     [Google Scholar]
  31. BhosaleU.A. TalpateK.A. ZambareM. SomaniR. Neuroprotective and nootropic activity of Clitorea ternatea Linn.(Fabaceae) leaves on diabetes induced cognitive decline in experimental animals.J. Pharm. Bioallied Sci.201461485510.4103/0975‑7406.124317 24459404
     [Google Scholar]
  32. SethiyaN. PatelM.B. MishraS.H. Phytopharmacologic aspects of Canscora decussata roem and schult.Pharmacogn. Rev.201047495710.4103/0973‑7847.65326 22228941
     [Google Scholar]
  33. SethiyaN.K. NahataA. SinghP.K. MishraS.H. Neuropharmacological evaluation on four traditional herbs used as nervine tonic and commonly available as Shankhpushpi in India.J. Ayurveda Integr. Med.2019101253110.1016/j.jaim.2017.08.012 29530454
     [Google Scholar]
  34. ShalavadiM.H. ChandrashekharV.M. MuchchandiI.S. Neuroprotective effect of Convolvulus pluricaulis Choisy in oxidative stress model of cerebral ischemia reperfusion injury and assessment of MAP2 in rats.J. Ethnopharmacol.202024911239310.1016/j.jep.2019.112393 31743764
     [Google Scholar]
  35. BihaqiS.W. SharmaM. SinghA.P. TiwariM. Neuroprotective role of Convolvulus pluricaulis on aluminium induced neurotoxicity in rat brain.J. Ethnopharmacol.2009124340941510.1016/j.jep.2009.05.038 19505562
     [Google Scholar]
  36. RachithaP. KrupashreeK. JayashreeG.V. KandikattuH.K. AmrutaN. GopalanN. RaoM.K. KhanumF. Chemical composition, antioxidant potential, macromolecule damage and neuroprotective activity of Convolvulus pluricaulis.J. Tradit. Complement. Med.20188448349610.1016/j.jtcme.2017.11.002 30302329
     [Google Scholar]
  37. MehlaJ. PahujaM. DetheS.M. AgarwalA. GuptaY.K. Amelioration of intracerebroventricular streptozotocin induced cognitive impairment by Evolvulus alsinoides in rats: In vitro and in vivo evidence.Neurochem. Int.20126171052106410.1016/j.neuint.2012.07.022 22892278
     [Google Scholar]
  38. GargG. PatilA.N. KumarR. BhatiaA. KasudhanK.S. PattanaikS. Protective role of Convolvulus pluricaulis on lipid abnormalities in high-fat diet with low dose streptozotocin-induced experimental rat model.J. Ayurveda Integr. Med.202011442643110.1016/j.jaim.2020.06.011 32814671
     [Google Scholar]
  39. DhunaK. Neuroprotective effect of Convolvulus pluricaulis methanol extract on hydrogen peroxide induced oxidative stress in human IMR32 neuroblastoma cell line.Br. Biotechnol. J.20122419221010.9734/BBJ/2012/1655
     [Google Scholar]
  40. HannanM.A. SultanaA. RahmanM.H. SohagA.M.A. DashR. UddinM.J. Protective mechanisms of nootropic herb shankhpushpi (Convolvulus pluricaulis) against dementia: Network pharmacology and computational approach.Evid. Based Complement. Alternat. Med.2022202211810.1155/2022/1015310
     [Google Scholar]
  41. FalachY.M. AmitT. Bar-AmO. WeinstockM. YoudimM.B.H. The involvement of mitogen‐activated protein (MAP) kinase in the regulation of amyloid precursor protein processing by novel cholinesterase inhibitors derived from rasagiline.FASEB J.200216121674167610.1096/fj.02‑0198fje 12206996
     [Google Scholar]
  42. DurairajanS.S.K. YuanQ. XieL. ChanW.S. KumW.F. KooI. LiuC. SongY. HuangJ.D. KleinW.L. LiM. Salvianolic acid B inhibits Aβ fibril formation and disaggregates preformed fibrils and protects against Aβ-induced cytotoxicty.Neurochem. Int.2008524-574175010.1016/j.neuint.2007.09.006 17964692
     [Google Scholar]
  43. LiuL.F. DurairajanS.S.K. LuJ.H. KooI. LiM. In vitro screening on amyloid precursor protein modulation of plants used in Ayurvedic and Traditional Chinese medicine for memory improvement.J. Ethnopharmacol.2012141275476010.1016/j.jep.2011.08.065 21920424
     [Google Scholar]
  44. DurairajanS.S.K. LiuL.F. LuJ.H. KooI. MaruyamaK. ChungS.K. HuangJ.D. LiM. Stimulation of non-amyloidogenic processing of amyloid-β protein precursor by cryptotanshinone involves activation and translocation of ADAM10 and PKC-α.J. Alzheimers Dis.201125224526210.3233/JAD‑2011‑102085 21403388
     [Google Scholar]
  45. SemwalD.K. KumarA. SemwalR.B. AndolaH.C. Convolvulus prostratus.Naturally Occurring Chemicals Against Alzheimer’s Disease.Elsevier202140942410.1016/B978‑0‑12‑819212‑2.00035‑9
     [Google Scholar]
  46. NathR. PalR. KumarR. SinghP.K. DixitR.K. SachanA.K. Effect of Convolvulus pluricaulis and omega-3 fatty acid alone and in combination on learning and memory.J Clin DIAGNOSTIC Res2022161FC01FC0610.7860/JCDR/2022/50694.15840
     [Google Scholar]
  47. ChouhanG. SolankiN. ShekhawatG.S. PariharS. Convolvulus prostratus Forssk: A memory boosting herb.Plant Sci. Today2023103869310.14719/pst.2110
     [Google Scholar]
  48. RajuN.R. RashmithaS.V. PavithraS. TorresE.A. KishorM. AcharR.R. Phytochemical Drug Discovery for Central Nervous System Disorders: Biochemistry and Therapeutic Effects.Wiley20238113610.1002/9781119794127.ch4
     [Google Scholar]
  49. AwathaleS.N. DhobleL.R. ItankarP.R. RautN.A. KokareD.M. Neuroactive herbal agents for cognitive dysfunction.Stud. Natur. Products Chemistr.20217019522610.1016/B978‑0‑12‑819489‑8.00002‑8
     [Google Scholar]
  50. DobrekL. GłowackaK. Depression and its phytopharmacotherapy—A narrative review.Int. J. Mol. Sci.2023245477210.3390/ijms24054772 36902200
     [Google Scholar]
  51. BasuN.K. DandiyaP.C. Chemical investigation of Convolvulus pluricaulis Chois.J. Am. Pharm. Assoc.1948371272810.1002/jps.3030370108 18899765
     [Google Scholar]
  52. Al-EnaziN.M. Phytochemical screening and biological activities of some species of alpinia and Convolvulus plants.Int. J. Pharmacol.201814330130910.3923/ijp.2018.301.309
     [Google Scholar]
  53. SowemimoB.O. FarnsworthN.R. Phytochemical investigation of Convolvulus arvensis (Convolvulaceae).J. Pharm. Sci.197362467867910.1002/jps.2600620431 4698995
     [Google Scholar]
  54. WitterS. WitterR. ViluR. SamosonA. Medical plants and nutraceuticals for amyloid-β fibrillation inhibition.J. Alzheimers Dis. Rep.20182123925210.3233/ADR‑180066 30599045
     [Google Scholar]
  55. GregoryJ. VengalasettiY.V. BredesenD.E. RaoR.V. Neuroprotective herbs for the management of alzheimer’s disease.Biomolecules202111454310.3390/biom11040543 33917843
     [Google Scholar]
  56. KizhakkeP. A.; Olakkaran, S.; Antony, A.; Tilagul K, S.; Hunasanahally, P.G. Convolvulus pluricaulis (Shankhapushpi) ameliorates human microtubule-associated protein tau (hMAPτ) induced neurotoxicity in alzheimer’s disease drosophila model.J. Chem. Neuroanat.20199511512210.1016/j.jchemneu.2017.10.002 29051039
     [Google Scholar]
  57. SharmaH. ChandolaH.M. Ayurvedic approach to food and dietary supplements for the brain and neurologic health.Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease.Elsevier201517317710.1016/B978‑0‑12‑411462‑3.00018‑7
     [Google Scholar]
  58. SethiyaN.K. MishraS. Simultaneous HPTLC analysis of ursolic acid, betulinic acid, stigmasterol and lupeol for the identification of four medicinal plants commonly available in the Indian market as Shankhpushpi.J. Chromatogr. Sci.201553581682310.1093/chromsci/bmu111 25217706
     [Google Scholar]
  59. SiddiquiN.A. AhmadN. MusthaqN. ChattopadhyayaI. KumriaR. GuptaS. Neuropharmacological profile of extracts of aerial parts of Convolvulus pluricaulis choisy in mice model.Open Neurol. J.201181111410.2174/1874205X01408010011 25110532
     [Google Scholar]
  60. AustinD.F. Evolvulus alsinoides (Convolvulaceae): An American herb in the old world.J. Ethnopharmacol.2008117218519810.1016/j.jep.2008.01.038 18384986
     [Google Scholar]
  61. AminH. DhimanK. SharmaR. VyasM. PrajapatiP. Shankhapushpi (Convolvulus pluricaulis Choisy): Validation of the ayurvedic therapeutic claims through contemporary studies.Int J Green Pharm20148419310.1016/j.ijpharm.2014.08.028
     [Google Scholar]
  62. ZafarR. AhmadS. MujeebM. Estimation of scopoletin in leaf and leaf callus of Convolvulus microphyllus Sieb. Vol. 67.Indian J. Pharm. Sci.2005675562564
     [Google Scholar]
  63. BalkrishnaA. ThakurP. VarshneyA. Phytochemical profile, pharmacological attributes and medicinal properties of Convolvulus prostratus – A cognitive enhancer herb for the management of neurodegenerative etiologies.Front. Pharmacol.20201117110.3389/fphar.2020.00171
     [Google Scholar]
  64. ShalavadiM.H. ChandrashekharV.M. MuchchandiI.S. Physicochemical and phytochemical screening of Convolvulus pluricaulis collected from Bagalkot, Karnataka.Int J Green Pharm.2018123S625S632
     [Google Scholar]
  65. KapadiaN. AcharyaN. AcharyaS. ShahM. Use of HPTLC to establish a distinct chemical profile for Shankhpushpi and for quantification of scopoletin in Convolvulus pluricaulis choisy and in commercial formulations of Shankhpushpi.J. Planar Chromatogr. Mod. TLC20061910919519910.1556/JPC.19.2006.3.4
     [Google Scholar]
  66. NiyatiA. A pharmacognostical study on Convolvulus prostratus forssk.J. Nat. Med.2015
     [Google Scholar]
  67. HrichiS. Chaâbane-BanaouesR. AlibrandoF. AltemimiA.B. BabbaO. MajdoubY.O.E. NasriH. MondelloL. BabbaH. MighriZ. CacciolaF. Chemical composition, antifungal and anti-biofilm activities of volatile fractions of Convolvulus althaeoides L. roots from tunisia.Molecules20222720683410.3390/molecules27206834 36296427
     [Google Scholar]
  68. HassineM. BerguaouiZ.A. ZnatiM. FlaminiG. Ben JannetH. HamzaM.A. Chemical composition, antibacterial and cytotoxic activities of the essential oil from the flowers of Tunisian Convolvulus althaeoides L.Nat. Prod. Res.2014281176977510.1080/14786419.2013.879476 24498906
     [Google Scholar]
  69. HolguinM.M.O. VideaP.J.R. MeitznerG. MartinezM.A. de la RosaG. MichelC.H.A. TorresdeyG.J.L. Biochemical and spectroscopic studies of the response of Convolvulus arvensis L. to chromium(III) and chromium(VI) stress.Environ. Toxicol. Chem.200625122022610.1897/05‑089R.1 16494245
     [Google Scholar]
  70. SaleemU. KhalidS. ZaibS. AnwarF. AkhtarM.F. HussainL. Wound healing potential and in silico appraisal of Convolvulus arvensis L. methanolic extract. Haq I ul.BioMed Res. Int.20222022137316010.1155/2022/1373160
     [Google Scholar]
  71. LuY. HeY. YangM. FanB.Y. Arvensic acids K and L, components of resin glycoside fraction from Convolvulus arvensis.Nat. Prod. Res.202135142303230710.1080/14786419.2019.1672069 31571506
     [Google Scholar]
  72. Abdul KhaliqH. OrtizS. AlhouayekM. MuccioliG.G. LeclercqQ.J. Dereplication and quantification of major compounds of Convolvulus arvensis L. extracts and assessment of their effect on lps-activated j774 macrophages.Molecules202227396310.3390/molecules27030963 35164229
     [Google Scholar]
  73. Imran TousifM. NazirM. SaleemM. TauseefS. UddinR. ZenginG. MahomoodallyF.M. AbbasZ. Total bioactive contents, metabolic profiling, docking studies, antioxidant and enzyme inhibition activities of Convolvulus arvensis L. and multivariate analysis to unravel a potential herb as natural resource for pharmaceutical industry.Chem. Biodivers.20221911e20220052110.1002/cbdv.202200521 36149393
     [Google Scholar]
  74. NojadehS.M. PouresmaeilM. HamzekhanluY.M. VendittiA. Phytochemical profile of fennel essential oils and possible applications for natural antioxidant and controlling Convolvulus arvensis L.Nat. Prod. Res.202135214164416810.1080/14786419.2020.1741580 32174182
     [Google Scholar]
  75. Al-RifaiA. AqelA. Al-WarhiT. WabaidurS.M. Al-OthmanZ.A. AhmedB.H.A.Y. Antibacterial, antioxidant activity of ethanolic plant extracts of some Convolvulus species and their DART-ToF-MS profiling.Evid. Based Complement. Alternat. Med.201720171910.1155/2017/5694305 29317894
     [Google Scholar]
  76. KhanM.U. Phytochemical analyses for antibacterial activity and therapeutic compounds of Convolvulus arvensis L., collected from the salt range of Pakistan. Adv. Life Sci.20152015
     [Google Scholar]
  77. NooriM. BahramiB. MousaviA. KhalighiA. JafariA. Flower flavonoids of Convolvulus L. species in Markazi Province, Iran.Asian J. Plant Sci.2016161455110.3923/ajps.2017.45.51
     [Google Scholar]
  78. AwaadA.S. RefaieA.A. MeligyE.R. ZainM. SolimanH. MarzokeM.S. SayedE.N. Novel compounds with new anti‐ulcergenic activity from Convolvulus pilosellifolius using bio‐guided fractionation.Phytother. Res.201630122060206410.1002/ptr.5730 27730681
     [Google Scholar]
  79. RajakarunaN. HarrisC.S. TowersG.H.N. Antimicrobial activity of plants collected from serpentine outcrops in Sri Lanka.Pharm. Biol.200240323524410.1076/phbi.40.3.235.5825
     [Google Scholar]
  80. WaliwitaC.W.A.L. Sri Lankan medicinal herbs used for the management of neurodegenerative diseases of the brain.Nutraceuticals in Brain Health and Beyond.Elsevier202037938910.1016/B978‑0‑12‑820593‑8.00027‑6
     [Google Scholar]
  81. BarbaV.V. CoronadoC.A. PérezH.O.R. FabresL.P.H. CamberosP.E. DíazN.F. MartínezD.N.E. iPSC for modeling neurodegenerative disorders.Regen. Ther.20201533233910.1016/j.reth.2020.11.006 33426236
     [Google Scholar]
  82. BreijyehZ. KaramanR. Comprehensive review on Alzheimer’s disease: Causes and treatment.Molecules20202524578910.3390/molecules25245789 33302541
     [Google Scholar]
  83. SeharU. RawatP. ReddyA.P. KopelJ. ReddyP.H. Amyloid beta in aging and Alzheimer’s disease.Int. J. Mol. Sci.202223211292410.3390/ijms232112924 36361714
     [Google Scholar]
  84. IqbalK. LiuF. GongC.X. Alzheimer disease therapeutics: Focus on the disease and not just plaques and tangles.Biochem. Pharmacol.201488463163910.1016/j.bcp.2014.01.002 24418409
     [Google Scholar]
  85. GayathriS. RaghuC.H. FayazS.M. Phytotherapeutics against Alzheimer’s Disease: Mechanism, molecular targets and challenges for drug development.CNS Neurol. Disord. Drug Targets202221540942610.2174/1871527320666210920120612 34544351
     [Google Scholar]
  86. BihaqiS. SinghA. TiwariM. Supplementation of Convolvulus pluricaulis attenuates scopolamine-induced increased tau and Amyloid precursor protein (AβPP) expression in rat brain.Indian J. Pharmacol.201244559359810.4103/0253‑7613.100383 23112420
     [Google Scholar]
  87. VinuthaB. PrashanthD. SalmaK. SreejaS.L. PratitiD. PadmajaR. RadhikaS. AmitA. VenkateshwarluK. DeepakM. Screening of selected Indian medicinal plants for acetylcholinesterase inhibitory activity.J. Ethnopharmacol.2007109235936310.1016/j.jep.2006.06.014 16950584
     [Google Scholar]
  88. SundaramoorM.K.P. PackiamK.K. In vitro enzyme inhibitory and cytotoxic studies with Evolvulus alsinoides (Linn.) Linn. Leaf extract: A plant from Ayurveda recognized as Dasapushpam for the management of Alzheimer’s disease and diabetes mellitus. BMC complement. med. ther.,202020112910.1186/s12906‑020‑02922‑7 32345272
     [Google Scholar]
  89. KarunakaranK.B. ThiyagarajA. SanthakumarK. Novel insights on acetylcholinesterase inhibition by Convolvulus pluricaulis, scopolamine and their combination in zebrafish.Nat. Prod. Bioprospect.2022121610.1007/s13659‑022‑00332‑5 35212831
     [Google Scholar]
  90. SharmaS. SharmaS. ChourasiaR. PandeyA. RaiA.K. SahooD. Alzheimer’s disease.Naturally Occurring Chemicals Against Alzheimer’s Disease.Elsevier2021112810.1016/B978‑0‑12‑819212‑2.00044‑X
     [Google Scholar]
  91. MathewM. SubramanianS. In vitro screening for anti-cholinesterase and antioxidant activity of methanolic extracts of ayurvedic medicinal plants used for cognitive disorders.PLoS One201491e8680410.1371/journal.pone.0086804
     [Google Scholar]
  92. ChorpitaB.F. BarlowD.H. The development of anxiety: The role of control in the early environment.Neurotic Parad2018222726410.4324/9781315619996‑2
     [Google Scholar]
  93. MalikJ. KaranM. VasishtK. Nootropic, anxiolytic and CNS-depressant studies on different plant sources of shankhpushpi.Pharm. Biol.201149121234124210.3109/13880209.2011.584539 21846173
     [Google Scholar]
  94. NahataA. PatilU.K. DixitV.K. Effect of Evolvulus alsinoides Linn. on learning behavior and memory enhancement activity in rodents.Phytother. Res.201024448649310.1002/ptr.2932 19610035
     [Google Scholar]
  95. YuenA.W.C. KeezerM.R. SanderJ.W. Epilepsy is a neurological and a systemic disorder.Epilepsy Behav.201878576110.1016/j.yebeh.2017.10.010 29175221
     [Google Scholar]
  96. VermaS. SinhaR. KumarP. AminF. JainJ. TanwarS. Study of Convolvulus pluricaulis for antioxidant and anticonvulsant activity.Cent. Nerv. Syst. Agents Med. Chem.2012121555910.2174/187152412800229161 22280406
     [Google Scholar]
  97. RathaK.K. MishraS.S. Anticonvulsant activity of Shankhapuspi (Convolvulus pluricaulis Chois) on Strychnine induced seizure in experimental animals.Int. J. Ayurveda Res.20123210.47552/ijam.v3i2.163
     [Google Scholar]
  98. PrisnieJ.C. SajobiT.T. WangM. PattenS.B. FiestK.M. BullochA.G.M. PringsheimT. WiebeS. JetteN. Effects of depression and anxiety on quality of life in five common neurological disorders.Gen. Hosp. Psychiatry201852586310.1016/j.genhosppsych.2018.03.009 29684713
     [Google Scholar]
  99. DhingraD. ValechaR. Evaluation of the antidepressant-like activity of Convolvulus pluricaulis choisy in the mouse forced swim and tail suspension tests.Med. Sci. Monit.2007137BR155BR161 17599020
     [Google Scholar]
  100. KumarV. Potential medicinal plants for CNS disorders: An overview.Phytother. Res.200620121023103510.1002/ptr.1970 16909441
     [Google Scholar]
  101. GuptaG.L. FernandesJ. Protective effect of Convolvulus pluricaulis against neuroinflammation associated depressive behavior induced by chronic unpredictable mild stress in rat.Biomed. Pharmacother.20191091698170810.1016/j.biopha.2018.11.046 30551424
     [Google Scholar]
  102. KumarS. GoyalL. SinghS. Tremor and rigidity in patients with Parkinson’s disease: Emphasis on epidemiology, pathophysiology and contributing factors.CNS Neurol. Disord. Drug Targets202221759660910.2174/1871527320666211006142100 34620070
     [Google Scholar]
  103. RawatC.S. PandeyS. Parkinson’s disease–An introduction.Techniques for Assessment of Parkinsonism for Diagnosis and Rehabilitation.Springer2022124
     [Google Scholar]
  104. BalestrinoR. SchapiraA.H.V. Parkinson disease.Eur. J. Neurol.2020271274210.1111/ene.14108 31631455
     [Google Scholar]
  105. PradhanP. MajhiO. BiswasA. JoshiV.K. SinhaD. Enhanced accumulation of reduced glutathione by Scopoletin improves survivability of dopaminergic neurons in Parkinson’s model.Cell Death Dis.202011973910.1038/s41419‑020‑02942‑8 32913179
     [Google Scholar]
  106. SalehiB. MarczakK.B. SkibaD. PatraJ.K. DasS.K. DasG. DjordjevićP.J.B. KostićA.Ž. KumarA.N.V. TripathiA. SnafiA.A.E. UçarA.D.K. KonovalovD.A. CsuporD. ShuklaI. AzmiL. MishraA.P. Sharifi-RadJ. SawickaB. MartinsN. TaheriY. FokouP.V.T. CapassoR. MartorellM. Convolvulus plant-A comprehensive review from phytochemical composition to pharmacy.Phytother. Res.202034231532810.1002/ptr.6540 31713286
     [Google Scholar]
  107. JaafarN.F. RamliM.E. SallehM.R. Extraction condition of Clitorea ternatea flower on antioxidant activities, total phenolic, total flavonoid and total anthocyanin contents.Trop. Life Sci. Res.202031211710.21315/tlsr2020.31.2.1 32922666
     [Google Scholar]
  108. ZhangY.J. GanR.Y. LiS. ZhouY. LiA.N. XuD.P. LiH.B. Antioxidant phytochemicals for the prevention and treatment of chronic diseases.Molecules20152012211382115610.3390/molecules201219753 26633317
     [Google Scholar]
  109. MorénC. deSouzaR.M. GiraldoD.M. UffC. Antioxidant therapeutic strategies in neurodegenerative diseases.Int. J. Mol. Sci.20222316932810.3390/ijms23169328 36012599
     [Google Scholar]
  110. LuW. ShiY. WangR. SuD. TangM. LiuY. LiZ. Antioxidant activity and healthy benefits of natural pigments in fruits: A review.Int. J. Mol. Sci.2021229494510.3390/ijms22094945 34066601
     [Google Scholar]
  111. da RosaM.M. de AmorimL.C. AlvesJ.V.O. AguiarI.F.S. OliveiraF.G.S. da SilvaM.V. dos SantosM.T.C. The promising role of natural products in Alzheimer’s disease.Brain Disorders2022710004910.1016/j.dscb.2022.100049
     [Google Scholar]
  112. BalajiK. HeanK.C. RavichandranK. ShikarwarM. In-vitro evaluation of antioxidant activity and total phenolic content of methanolic extract of Convolvulus pluricaulis.Res. J. Pharm. Biol. Chem. Sci.201456959964
     [Google Scholar]
  113. YadavM.K. SinghS.K. SinghM. MishraS.S. SinghA.K. TripathiJ.S. TripathiY.B. Neuroprotective activity of Evolvulus alsinoides & Centella asiatica ethanolic extracts in scopolamine-induced amnesia in swiss albino mice.Open Access Maced. J. Med. Sci.2019771059106610.3889/oamjms.2019.247 31049081
     [Google Scholar]
  114. SethiyaN. MishraS.H. RajaM.M.M.K. Antioxidant markers based TLC-DPPH differentiation on four commercialized botanical sources of Shankhpushpi (A Medhya Rasayana): A preliminary assessment.J. Adv. Pharm. Technol. Res.201341253010.4103/2231‑4040.107497 23662279
     [Google Scholar]
  115. GomathiD. RavikumarG. KalaiselviM. DevakiK. UmaC. Antioxidant activity and functional group analysis of Evolvulus alsinoides.Chin. J. Nat. Med.2014121182783210.1016/S1875‑5364(14)60124‑2 25480513
     [Google Scholar]
  116. GanieSH AliZ DasS SrivastavaPS SharmaMP Genetic diversity and chemical profiling of different populations of Convolvulus pluricaulis (convolvulaceae): An important herb of ayurvedic medicine.3 Biotech20155329530210.1007/s13205‑014‑0227‑8
     [Google Scholar]
  117. MalikJ. ChoudharyS. KumarP. Protective effect of Convolvulus pluricaulis standardized extract and its fractions against 3-nitropropionic acid-induced neurotoxicity in rats.Pharm. Biol.201553101448145710.3109/13880209.2014.984856 25853968
     [Google Scholar]
/content/journals/cbc/10.2174/0115734072292339240416095600
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Shankhpushpi (Convolvulus pluricaulis): Exploring its Cognitive Enhancing Mechanisms and Therapeutic Potential in Neurodegenerative Disorders
Curr. Bioact. Compd. 21, E290424229510 (2025); https://doi.org/10.2174/0115734072292339240416095600
/content/journals/cbc/10.2174/0115734072292339240416095600
/content/journals/cbc/10.2174/0115734072292339240416095600
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  • Article Type:     Review Article
Keyword(s): alzheimer; anxiety; Convolvulus pluricaulis; epilepsy; parkinson; scopoletin; Shankhpushpi

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