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Volume 18, Issue 1
  • ISSN: 1874-6098
  • E-ISSN: 1874-6128

Abstract

Alzheimer's disease (AD) has many etiologies and the impact of gender on AD changes throughout time. As a consequence of advancements in precision medical procedures and methodology, Alzheimer's disease is now better understood and treated. Several risk factors may be addressed to lower one's chances of developing Alzheimer's disease or associated dementia (ADRD).

The presence of amyloid-α protein senile plaques, intracellular tau protein neurofibrillary tangles (NfTs), neurodegeneration, and neuropsychiatric symptoms (NPS) characterizes Alzheimer's disease. NPS is common in persons with Alzheimer's disease dementia, although its presentation varies widely. Gender differences might explain this clinical variability.

The fundamental goal of this review is to 1) emphasize the function of old age, sex, and gender in the development of Alzheimer's disease, dementia, and ADRD, and 2) explain the importance of sexual hormones, education, and APOE (Apolipoprotein E) status. This is a narrative summary of new ideas and concepts on the differences in the chance of developing dementia or Alzheimer's disease between men and women.

A more thorough examination of risk and protective variables in both men and women might hasten research into the epidemiology of neurological illnesses such as dementia and Alzheimer's disease. Similarly, future preventive efforts should target men and women separately.

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References

  1. AssociationA. 2021 Alzheimer's disease facts and figures.Alzheimers Dement202117332740610.1002/alz.12328
     [Google Scholar]
  2. PrinceM.J. WimoA. GuerchetM.M. AliG.C. WuY-T. PrinaM. The global impact of dementia: An analysis of prevalence, incidence, cost and trends.Alzheimer’s Dis. Int.201584126
     [Google Scholar]
  3. MatthewsF.E. StephanB.C.M. RobinsonL. JaggerC. BarnesL.E. ArthurA. BrayneC. Comas-HerreraA. WittenbergR. DeningT. McCrackenC.F.M. MoodyC. ParryB. GreenE. BarnesR. WarwickJ. GaoL. MattisonA. BaldwinC. HarrisonS. WoodsB. McKeithI.G. InceP.G. WhartonS.B. ForsterG. A two decade dementia incidence comparison from the cognitive function and ageing studies I and II.Nat. Commun.2016711139810.1038/ncomms1139827092707
     [Google Scholar]
  4. ArdekaniB.A. ConvitA. BachmanA.H. Analysis of the MIRIAD data shows sex diferences in hippocampal atrophy progression.J. Alzheimers Dis.201650384785710.3233/JAD‑15078026836168
     [Google Scholar]
  5. SkupM. ZhuH. WangY. GiovanelloK.S. LinJ. ShenD. ShiF. GaoW. LinW. FanY. ZhangH. Sex differences in grey matter atrophy patterns among AD and aMCI patients: Results from ADNI.Neuroimage201156389090610.1016/j.neuroimage.2011.02.06021356315
     [Google Scholar]
  6. NebelR.A. AggarwalN.T. BarnesL.L. GallagherA. GoldsteinJ.M. KantarciK. MallampalliM.P. MorminoE.C. ScottL. YuW.H. MakiP.M. MielkeM.M. Understanding the impact of sex and gender in Alzheimer’s disease: A call to action.Alzheimers Dement.20181491171118310.1016/j.jalz.2018.04.00829907423
     [Google Scholar]
  7. PodcasyJ.L. EppersonC.N. Considering sex and gender in Alzheimer disease and other dementias.Dialogues Clin. Neurosci.201618443744610.31887/DCNS.2016.18.4/cepperson28179815
     [Google Scholar]
  8. FratiglioniL. ViitanenM. von StraussE. TontodonatiV. HerlitzA. WinbladB. Very old women at highest risk of dementia and Alzheimer’s disease: Incidence data from the Kungsholmen Project, Stockholm.Neurology199748113213810.1212/WNL.48.1.1329008508
     [Google Scholar]
  9. MielkeM.M. AggarwalN.T. CastelarV.C. AgarwalP. UrquijoA.E.M. BrettB. SerratB.A. Consideration of sex and gender in alzheimer’s disease related disorders from a global perspective.Alzheimer’s & Dem202218122707272410.1002/alz.12662
     [Google Scholar]
  10. MielkeM.M. Sex and gender differences in alzheimer’s disease dementia.Psychiatr. Times20183511141730820070
     [Google Scholar]
  11. EikelboomW.S. PanM. OssenkoppeleR. CoesmansM. GatchelJ.R. IsmailZ. Sex differences in neuropsychiatric symptoms in alzheimer’s disease dementia: A meta-analysis.Alzheimers Res Ther20221414810.1186/s13195‑022‑00991‑z
     [Google Scholar]
  12. ArmstrongR.A. What causes alzheimer’s disease?Folia Neuropathol.201351316918810.5114/fn.2013.3770224114635
     [Google Scholar]
  13. AshrafG. GreigN. KhanT. HassanI. TabrezS. ShakilS. SheikhI. ZaidiS. AkramM. JabirN. FirozC. NaeemA. AlhazzaI. DamanhouriG. KamalM. Protein misfolding and aggregation in Alzheimer’s disease and type 2 diabetes mellitus.CNS Neurol. Disord. Drug Targets20141371280129310.2174/187152731366614091709551425230234
     [Google Scholar]
  14. MuralidarS. AmbiS.V. SekaranS. ThirumalaiD. PalaniappanB. Role of tau protein in Alzheimer’s disease: The prime pathological player.Int. J. Biol. Macromol.202016311599161710.1016/j.ijbiomac.2020.07.32732784025
     [Google Scholar]
  15. JhaS.K. JhaN.K. KumarD. SharmaR. ShrivastavaA. AmbastaR.K. KumarP. Stress-Induced Synaptic Dysfunction and Neurotransmitter Release in Alzheimer’s Disease: Can Neurotransmitters and Neuromodulators be Potential Therapeutic Targets?J. Alzheimers Dis.20175741017103910.3233/JAD‑16062327662312
     [Google Scholar]
  16. HenekaM. ObanionM. Inflammatory processes in Alzheimer’s disease.J. Neuroimmunol.20071841-2699110.1016/j.jneuroim.2006.11.01717222916
     [Google Scholar]
  17. HuangW.J. ZhangX. ChenW.W. Role of oxidative stress in Alzheimer’s disease.Biomed. Rep.20164551952210.3892/br.2016.63027123241
     [Google Scholar]
  18. YamazakiY. ZhaoN. CaulfieldT.R. LiuC.C. BuG. Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies.Nat. Rev. Neurol.201915950151810.1038/s41582‑019‑0228‑731367008
     [Google Scholar]
  19. BekrisL.M. YuC.E. BirdT.D. TsuangD.W. Genetics of Alzheimer disease.J. Geriatr. Psychiatry Neurol.201023421322710.1177/089198871038357121045163
     [Google Scholar]
  20. GurvichC. hoy K, Thomas N, Kulkarni J. Sex differences and the influence of sex hormones on cognition through aldulthood and the aging process.Brain Sci.2018816316710.3390/brainsci809016330154388
     [Google Scholar]
  21. McCarthyM.M. Multifaceted origins of sex differences in the brain.Philos. Trans. R. Soc. Lond. B Biol. Sci.201637116882015010610.1098/rstb.2015.010626833829
     [Google Scholar]
  22. RahmanA. JacksonH. HristovH. IsaacsonR.S. SaifN. ShettyT. EtinginO. HenchcliffeC. BrintonR.D. MosconiL. Sex and gender driven modifiers of Alzheimer’s: The role for estrogenic control across age, race, medical, and lifestyle risks.Front. Aging Neurosci.20191131532010.3389/fnagi.2019.0031531803046
     [Google Scholar]
  23. GurvichC. ThomasN. KulkarniJ. Sex differences in cognition and aging and the influence of sex hormones.Handb. Clin. Neurol.202017510311510.1016/B978‑0‑444‑64123‑6.00008‑433008519
     [Google Scholar]
  24. JoelD McCarthyMM Incorporating sex as a biological variable in neuropsychiatric research: Where are we now and where should we be?Neuro Psych. Pharmacol.201742237938510.1038/npp.2016.79
     [Google Scholar]
  25. JoelD. BermanZ. TavorI. WexlerN. GaberO. SteinY. ShefiN. PoolJ. UrchsS. MarguliesD.S. LiemF. HänggiJ. JänckeL. AssafY. Sex beyond the genitalia: The human brain mosaic.Proc. Natl. Acad. Sci. USA201511250154681547310.1073/pnas.150965411226621705
     [Google Scholar]
  26. FelittiV.J. AndaR.F. NordenbergD. WilliamsonD.F. SpitzA.M. EdwardsV. KossM.P. MarksJ.S. Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study.Am. J. Prev. Med.199814424525810.1016/S0749‑3797(98)00017‑89635069
     [Google Scholar]
  27. CarcaillonL. Brailly-TabardS. AncelinM.L. TzourioC. Foubert-SamierA. DartiguesJ.F. Guiochon-MantelA. ScarabinP.Y. Low testosterone and the risk of dementia in elderly men: Impact of age and education.Alzheimers Dement.2014105SSuppl.S306S31410.1016/j.jalz.2013.06.00624035146
     [Google Scholar]
  28. Spremo-PotparevićB. ŽivkovićL. DjelićN. Plećaš-SolarovićB. SmithM.A. BajićV. Spremo-Postparevic Premature centromere division of the X chromosome in neurons in Alzheimer’s disease.J. Neurochem.200810652218222310.1111/j.1471‑4159.2008.05555.x
     [Google Scholar]
  29. CarrelL. WillardH.F. X-inactivation profile reveals extensive variability in X-linked gene expression in females.Nature2005434703140040410.1038/nature0347915772666
     [Google Scholar]
  30. GreenfieldA. CarrelL. PennisiD. PhilippeC. QuaderiN. SiggersP. SteinerK. TamP.P. MonacoA.P. WillardH.F. KoopmanP. The UTX gene escapes X inactivation in mice and humans.Hum. Mol. Genet.19987473774210.1093/hmg/7.4.7379499428
     [Google Scholar]
  31. ForsbergL.A. GisselssonD. DumanskiJ.P. Mosaicism in health and disease — clones picking up speed.Nat. Rev. Genet.201718212814210.1038/nrg.2016.14527941868
     [Google Scholar]
  32. DumanskiJ.P. LambertJ.C. RasiC. GiedraitisV. DaviesH. Grenier-BoleyB. LindgrenC.M. CampionD. DufouilC. PasquierF. AmouyelP. LannfeltL. IngelssonM. KilanderL. LindL. ForsbergL.A. European Alzheimer’s Disease Initiative Investigators Mosaic loss of chromosome Y in blood is associated with Alzheimer disease.Am. J. Hum. Genet.20169861208121910.1016/j.ajhg.2016.05.01427231129
     [Google Scholar]
  33. CorderE.H. SaundersA.M. StrittmatterW.J. SchmechelD.E. GaskellP.C. SmallG.W. RosesA.D. HainesJ.L. Pericak-VanceM.A. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families.Science1993261512392192310.1126/science.83464438346443
     [Google Scholar]
  34. SherringtonR. RogaevE.I. LiangY. RogaevaE.A. LevesqueG. IkedaM. ChiH. LinC. LiG. HolmanK. TsudaT. MarL. FoncinJ.F. BruniA.C. MontesiM.P. SorbiS. RaineroI. PinessiL. NeeL. ChumakovI. PollenD. BrookesA. SanseauP. PolinskyR.J. WascoW. Da SilvaH.A.R. HainesJ.L. Pericak-VanceM.A. TanziR.E. RosesA.D. FraserP.E. RommensJ.M. St George-HyslopP.H. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer’s disease.Nature1995375653475476010.1038/375754a07596406
     [Google Scholar]
  35. MorleyJ.E. FarrS.A. The role of amyloid-beta in the regulation of memory.Biochem. Pharmacol.201488447948510.1016/j.bcp.2013.12.01824398426
     [Google Scholar]
  36. LambertJ.C. HeathS. EvenG. CampionD. SleegersK. HiltunenM. CombarrosO. ZelenikaD. BullidoM.J. TavernierB. LetenneurL. BettensK. BerrC. PasquierF. FiévetN. Barberger-GateauP. EngelborghsS. De DeynP. MateoI. FranckA. HelisalmiS. PorcelliniE. HanonO. de PancorboM.M. LendonC. DufouilC. JaillardC. LeveillardT. AlvarezV. BoscoP. MancusoM. PanzaF. NacmiasB. BossùP. PiccardiP. AnnoniG. SeripaD. GalimbertiD. HannequinD. LicastroF. SoininenH. RitchieK. BlanchéH. DartiguesJ.F. TzourioC. GutI. Van BroeckhovenC. AlpérovitchA. LathropM. AmouyelP. European Alzheimer’s Disease Initiative Investigators Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer’s disease.Nat. Genet.200941101094109910.1038/ng.43919734903
     [Google Scholar]
  37. ChapuisJ. HansmannelF. GistelinckM. MounierA. Van CauwenbergheC. KolenK.V. GellerF. SottejeauY. HaroldD. DourlenP. Grenier-BoleyB. KamataniY. DelepineB. DemiautteF. ZelenikaD. ZommerN. HamdaneM. BellenguezC. DartiguesJ-F. HauwJ-J. LetronneF. AyralA-M. SleegersK. SchellensA. BroeckL.V. EngelborghsS. De DeynP.P. VandenbergheR. O’DonovanM. OwenM. EpelbaumJ. MerckenM. KarranE. BantscheffM. DrewesG. JobertyG. CampionD. OctaveJ-N. BerrC. LathropM. CallaertsP. MannD. WilliamsJ. BuéeL. DewachterI. Van BroeckhovenC. AmouyelP. MoecharsD. DermautB. LambertJ-C. GERAD consortium Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology.Mol. Psychiatry201318111225123410.1038/mp.2013.123399914
     [Google Scholar]
  38. BarhaC.K. BestJ.R. RosanoC. YaffeK. CatovJ.M. Liu-AmbroseT. Sex-specific relationship between long-term maintenance of physical activity and cognition in the Health ABC Study: potential role of hippocampal and dorsolateral prefrontal cortex volume.J. Gerontol. A Biol. Sci. Med. Sci.202075476477010.1093/gerona/glz09330958523
     [Google Scholar]
  39. YaffeK. LwiS.J. HoangT.D. XiaF. BarnesD.E. MaguenS. PeltzC.B. Military-related risk factors in female veterans and risk of dementia.Neurology2019923e205e21110.1212/WNL.000000000000677830541865
     [Google Scholar]
  40. AdamsonM.M. ShakilS. SultanaT. HasanM.A. MubarakF. EnamS.A. ParvazM.A. RaziA. Brain injury and dementia in Pakistan: current perspectives.Front. Neurol.20201129910.3389/fneur.2020.0029932425875
     [Google Scholar]
  41. ZimmerZ. FraserK. Grol-ProkopczykH. ZajacovaA. A global study of pain prevalence across 52 countries: examining the role of country level contextual factors.Pain2022163917405010.1097/j.pain.000000000000255735027516
     [Google Scholar]
  42. ElzahafR.A. TashaniO.A. UnsworthB.A. JohnsonM.I. The prevalence of chronic pain with an analysis of countries with a Human Development Index less than 0.9: a systematic review without meta-analysis.Curr. Med. Res. Opin.20122871221122910.1185/03007995.2012.70313222697274
     [Google Scholar]
  43. FillingimR.B. Individual differences in pain: understanding the mosaic that makes pain personal.Pain20171581Suppl. 1S11S1810.1097/j.pain.000000000000077527902569
     [Google Scholar]
  44. FillingimR.B. Sex, gender and pain.Principles of Gender-Specific Medicine3rd ed LegatoM. Academic Press201748149610.1016/B978‑0‑12‑803506‑1.00038‑3
     [Google Scholar]
  45. HarilnC.M.C. ParfittM. LegrainS. Pérez-TurJ. BrousseauT. EvansA. BerrC. VldalO. RoquesP. GourletV. FruchartJ-C. DelacourteA. RossorM. AmouyelP. Apolipoprotein E, ɛ4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer’s disease: Analysis of the 19q13.2 chromosomal region.Hum. Mol. Genet.19943456957410.1093/hmg/3.4.5698069300
     [Google Scholar]
  46. StrittmatterW.J. SaundersA.M. SchmechelD. Pericak-VanceM. EnghildJ. SalvesenG.S. RosesA.D. Apolipoprotein E: High-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.Proc. Natl. Acad. Sci.19939051977198110.1073/pnas.90.5.19778446617
     [Google Scholar]
  47. HoltzmanD.M. BalesK.R. TenkovaT. FaganA.M. ParsadanianM. SartoriusL.J. MackeyB. OlneyJ. McKeelD. WozniakD. PaulS.M. Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer’s disease.Proc. Natl. Acad. Sci.20009762892289710.1073/pnas.05000479710694577
     [Google Scholar]
  48. KimJ. BasakJ.M. HoltzmanD.M. The role of apolipoprotein E in Alzheimer’s disease.Neuron200963328730310.1016/j.neuron.2009.06.02619679070
     [Google Scholar]
  49. RichardsG.C. LlukaL.J. SmithM.T. HaslamC. MooreB. O’CallaghanJ. StrongJ. Effects of long-term opioid analgesics on cognitive performance and plasma cytokine concentrations in patients with chronic low back pain: A cross-sectional pilot study.Pain Rep.201834e66910.1097/PR9.000000000000066930123859
     [Google Scholar]
  50. SchiltenwolfM. AkbarM. HugA. PfüllerU. GantzS. NeubauerE. FlorH. WangH. Evidence of specific cognitive deficits in patients with chronic low back pain under long-term substitution treatment of opioids.Pain Physician201417192024452649
     [Google Scholar]
  51. MielkeM. VemuriP. RoccaW. Clinical epidemiology of Alzheimer’s disease: Assessing sex and gender differences.Clin. Epidemiol.20146374810.2147/CLEP.S3792924470773
     [Google Scholar]
  52. Alzheimer’s Association2015 Alzheimer’s disease facts and figures.Alzheimers Dement.201511333238410.1016/j.jalz.2015.02.00325984581
     [Google Scholar]
  53. SeshadriS. WolfP.A. BeiserA. AuR. McNultyK. WhiteR. D’AgostinoR.B. Lifetime risk of dementia and Alzheimer’s disease.Neurology19974961498150410.1212/WNL.49.6.14989409336
     [Google Scholar]
  54. KuaE.H. HoE. TanH.H. TsoiC. ThngC. MahendranR. The natural history of dementia.Psychogeriatrics201414319620110.1111/psyg.1205325323961
     [Google Scholar]
  55. BurnsA. LewisG. JacobyR. LevyR. Factors affecting survival in Alzheimer’s disease.Psychol. Med.199121236337010.1017/S00332917000204681876641
     [Google Scholar]
  56. FarrerL.A. CupplesL.A. HainesJ.L. HymanB. KukullW.A. MayeuxR. MyersR.H. Pericak-VanceM.A. RischN. van DuijnC.M. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis.JAMA1997278161349135610.1001/jama.1997.035501600690419343467
     [Google Scholar]
  57. AltmannA. TianL. HendersonV.W. GreiciusM.D. Sex modifies the APOE ‐related risk of developing Alzheimer disease.Ann. Neurol.201475456357310.1002/ana.2413524623176
     [Google Scholar]
  58. KimS. KimM.J. KimS. KangH.S. LimS.W. MyungW. LeeY. HongC.H. ChoiS.H. NaD.L. SeoS.W. KuB.D. KimS.Y. KimS.Y. JeongJ.H. ParkS.A. CarrollB.J. KimD.K. Gender differences in risk factors for transition from mild cognitive impairment to Alzheimer’s disease: A CREDOS study.Compr. Psychiatry20156211412210.1016/j.comppsych.2015.07.00226343475
     [Google Scholar]
  59. ShelineY.I. WestT. YarasheskiK. SwarmR. JasielecM.S. FisherJ.R. FickerW.D. YanP. XiongC. FrederiksenC. GrzelakM.V. ChottR. BatemanR.J. MorrisJ.C. MintunM.A. LeeJ.M. CirritoJ.R. An antidepressant decreases CSF Aβ production in healthy individuals and in transgenic AD mice.Sci. Transl. Med.20146236236re410.1126/scitranslmed.300816924828079
     [Google Scholar]
  60. ShanmuganS. EppersonC.N. Estrogen and the prefrontal cortex: Towards a new understanding of estrogen’s effects on executive functions in the menopause transition.Hum. Brain Mapp.201435384786510.1002/hbm.2221823238908
     [Google Scholar]
  61. HaraY. WatersE.M. McEwenB.S. MorrisonJ.H. Estrogen effects on cognitive and synaptic health over the lifecourse.Physiol. Rev.201595378580710.1152/physrev.00036.201426109339
     [Google Scholar]
  62. BaileyM.E. WangA.C.J. HaoJ. JanssenW.G.M. HaraY. DumitriuD. HofP.R. MorrisonJ.H. Interactive effects of age and estrogen on cortical neurons: Implications for cognitive aging.Neuroscience201119114815810.1016/j.neuroscience.2011.05.04521664255
     [Google Scholar]
  63. BrintonR.D. The healthy cell bias of estrogen action: Mitochondrial bioenergetics and neurological implications.Trends Neurosci.2008311052953710.1016/j.tins.2008.07.00318774188
     [Google Scholar]
  64. ShamiehA.E. CostanianC. KassirR. SiestV.S. TadmouriB.N. APOE genotypes in Lebanon: Distribution and association with hypercholesterolemia and Alzheimer’s disease.Per. Med.201811010.2217/pme‑2018‑006730457419
     [Google Scholar]
  65. MasriI. SalamiA. ShamiehS.E. Bissar-TadmouriN. rs3851179G>A in PICALM is protective against alzheimer’s disease in five different countries surrounding the mediterranean.Curr. Aging Sci.2019121710.2174/187460981266619101914323731648652
     [Google Scholar]
  66. DanielJ.M. WittyC.F. RodgersS.P. Long-term consequences of estrogens administered in midlife on female cognitive aging.Horm. Behav.201574778510.1016/j.yhbeh.2015.04.01225917862
     [Google Scholar]
  67. AuA. FeherA. McPheeL. JessaA. OhS. EinsteinG. Estrogens, inflammation and cognition.Front. Neuroendocrinol.2016408710010.1016/j.yfrne.2016.01.00226774208
     [Google Scholar]
  68. VegetoE. BenedusiV. MaggiA. Estrogen anti-inflammatory activity in brain: A therapeutic opportunity for menopause and neurodegenerative diseases.Front. Neuroendocrinol.200829450751910.1016/j.yfrne.2008.04.00118522863
     [Google Scholar]
  69. LinJ. KroenkeC.H. EpelE. KennaH.A. WolkowitzO.M. BlackburnE. RasgonN.L. Greater endogenous estrogen exposure is associated with longer telomeres in postmenopausal women at risk for cognitive decline.Brain Res.2011137922423110.1016/j.brainres.2010.10.03320965155
     [Google Scholar]
  70. LiR. CuiJ. ShenY. Brain sex matters: Estrogen in cognition and Alzheimer’s disease.Mol. Cell. Endocrinol.20143891-2132110.1016/j.mce.2013.12.01824418360
     [Google Scholar]
  71. HanamsagarR. BilboS.D. Sex differences in neurodevelopmental and neurodegenerative disorders: Focus on microglial function and neuroinflammation during development.J. Steroid Biochem. Mol. Biol.201616012713310.1016/j.jsbmb.2015.09.03926435451
     [Google Scholar]
  72. HallJ.R. WiechmannA.R. JohnsonL.A. EdwardsM. BarberR.C. WinterA.S. SinghM. O’BryantS.E. Biomarkers of vascular risk, systemic inflammation, and microvascular pathology and neuropsychiatric symptoms in Alzheimer’s disease.J. Alzheimers Dis.201335236337110.3233/JAD‑12235923403534
     [Google Scholar]
  73. PetersonB.L. WonS. GeddesR.I. SayeedI. SteinD.G. Sex-related differences in effects of progesterone following neonatal hypoxic brain injury.Behav. Brain Res.201528615216510.1016/j.bbr.2015.03.00525746450
     [Google Scholar]
  74. DeakT. QuinnM. CidlowskiJ.A. VictoriaN.C. MurphyA.Z. SheridanJ.F. Neuroimmune mechanisms of stress: Sex differences, developmental plasticity, and implications for pharmacotherapy of stress-related disease.Stress201518436738010.3109/10253890.2015.105345126176590
     [Google Scholar]
  75. NamaN. MacPhersonP. SampsonM. McMillanH.J. Medical students’ perception of lesbian, gay, bisexual, and transgender (LGBT) discrimination in their learning environment and their self-reported comfort level for caring for LGBT patients: A survey study.Med. Educ. Online2017221136885010.1080/10872981.2017.136885028853327
     [Google Scholar]
  76. WangW. XieX. YuanT. WangY. ZhaoF. ZhouZ. ZhangH. Epidemiological trends of maternal hypertensive disorders of pregnancy at the global, regional, and national levels: A population‐based study.BMC Pregnancy Childbirth202121136410.1186/s12884‑021‑03809‑233964896
     [Google Scholar]
  77. McCarthyJ. Six in 10 Americans worry about higher healthcare premiums.2018Available from: https://news.gallup.com/poll/245312/six-americans-worry-higher-healthcare-premiums.aspx
  78. CurrierA. McKayT. Pursuing social justice through public health: gender and sexual diversity activism in Malawi.Crit. Afr. Stud.201791719010.1080/21681392.2017.128363730546970
     [Google Scholar]
  79. KachenA. PharrJ.R. Health care access and utilization by transgender populations: A United States transgender survey study.Transgend. Health20205314114810.1089/trgh.2020.001733644308
     [Google Scholar]
  80. MielkeM.M. MilicN.M. WeissgerberT.L. WhiteW.M. KantarciK. MosleyT.H. WindhamB.G. SimpsonB.N. TurnerS.T. GarovicV.D. Impaired cognition and brain atrophy decades after hypertensive pregnancy disorders.Circ. Cardiovasc. Qual. Outcomes201692 (S1)S70S7610.1161/CIRCOUTCOMES.115.00246126908863
     [Google Scholar]
  81. WiegmanM.J. ZeemanG.G. AukesA.M. BolteA.C. FaasM.M. AarnoudseJ.G. de GrootJ.C. Regional distribution of cerebral white matter lesions years after preeclampsia and eclampsia.Obstet. Gynecol.2014123479079510.1097/AOG.000000000000016224785606
     [Google Scholar]
  82. FieldsJA GarovicVD MielkeMM KantarciK JayachandranM WhiteWM Preeclampsia and cognitive impairment later in life.Am J Obstet Gynecol.201721774. e174. e1110.1016/j.ajog.2017.03.008
     [Google Scholar]
  83. ShaabanC.E. RosanoC. CohenA.D. HuppertT. ButtersM.A. HengeniusJ. ParksW.T. CatovJ.M. Cognition and cerebrovascular reactivity in midlife women with history of preeclampsia and placental evidence of maternal vascular malperfusion.Front. Aging Neurosci.20211363757410.3389/fnagi.2021.63757434017243
     [Google Scholar]
  84. GarovicV.D. WhiteW.M. VaughanL. SaikiM. ParashuramS. Garcia-ValenciaO. WeissgerberT.L. MilicN. WeaverA. MielkeM.M. Incidence and long-term outcomes of hypertensive disorders of pregnancy.J. Am. Coll. Cardiol.202075182323233410.1016/j.jacc.2020.03.02832381164
     [Google Scholar]
  85. GervaisN.J. AuA. AlmeyA. DuchesneA. GravelsinsL. BrownA. ReubenR. Baker-SullivanE. SchwartzD.H. EvansK. BernardiniM.Q. EisenA. MeschinoW.S. FoulkesW.D. HampsonE. EinsteinG. Cognitive markers of dementia risk in middle-aged women with bilateral salpingo-oophorectomy prior to menopause.Neurobiol. Aging2020941610.1016/j.neurobiolaging.2020.04.01932497876
     [Google Scholar]
  86. ZeydanB. TosakulwongN. SchwarzC.G. SenjemM.L. GunterJ.L. ReidR.I. RoccaG.L. LesnickT.G. SmithC.Y. BaileyK.R. LoweV.J. RobertsR.O. JackC.R.Jr PetersenR.C. MillerV.M. MielkeM.M. RoccaW.A. KantarciK. Association of bilateral salpingo-oophorectomy before menopause onset with medial temporal lobe neurodegeneration.JAMA Neurol.20197619510010.1001/jamaneurol.2018.305730326011
     [Google Scholar]
  87. RyanJ. ScaliJ. CarrièreI. AmievaH. RouaudO. BerrC. RitchieK. AncelinM-L. Impact of a premature menopause on cognitive function in later life.BJOG2014121131729173910.1111/1471‑0528.1282824802975
     [Google Scholar]
  88. RoccaW.A. BowerJ.H. MaraganoreD.M. AhlskogJ.E. GrossardtB.R. de AndradeM. MeltonL.J.III Increased risk of cognitive impairment or dementia in women who underwent oophorectomy before menopause.Neurology200769111074108310.1212/01.wnl.0000276984.19542.e617761551
     [Google Scholar]
  89. BoveR. SecorE. ChibnikL.B. BarnesL.L. SchneiderJ.A. BennettD.A. De JagerP.L. Age at surgical menopause influences cognitive decline and Alzheimer pathology in older women.Neurology201482322222910.1212/WNL.000000000000003324336141
     [Google Scholar]
  90. SommerladA. KivimäkiM. LarsonE.B. RöhrS. ShiraiK. Singh-ManouxA. LivingstonG. Social participation and risk of developing dementia.Nature Aging20233553254510.1038/s43587‑023‑00387‑037202513
     [Google Scholar]
  91. HsiaoY.H. ChangC.H. GeanP.W. Impact of social relationships on Alzheimer’s memory impairment: Mechanistic studies.J. Biomed. Sci.2018251310.1186/s12929‑018‑0404‑x29325565
     [Google Scholar]
  92. MillsK.T. StefanescuA. HeJ. The global epidemiology of hypertension.Nat. Rev. Nephrol.202016422323710.1038/s41581‑019‑0244‑232024986
     [Google Scholar]
  93. ChuiH.C. ZhengL. ReedB.R. VintersH.V. MackW.J. Vascular risk factors and Alzheimer’s disease: Are these risk factors for plaques and tangles or for concomitant vascular pathology that increases the likelihood of dementia? An evidence-based review.Alzheimers Res. Ther.20124111310.1186/alzrt9822182734
     [Google Scholar]
  94. RamirezL.A. SullivanJ.C. Sex differences in hypertension: Where we have been and where we are going.Am. J. Hypertens.201831121247125410.1093/ajh/hpy14830299518
     [Google Scholar]
  95. GabinJ.M. TambsK. SaltvedtI. SundE. HolmenJ. Association between blood pressure and Alzheimer disease measured up to 27 years prior to diagnosis: The HUNT Study.Alzheimers Res. Ther.2017913710.1186/s13195‑017‑0262‑x28569205
     [Google Scholar]
  96. KimmH. LeeP.H. ShinY.J. ParkK.S. JoJ. LeeY. KangH.C. JeeS.H. Mid-life and late-life vascular risk factors and dementia in Korean men and women.Arch. Gerontol. Geriatr.2011523e117e12210.1016/j.archger.2010.09.00420932588
     [Google Scholar]
  97. SantilliF. D’ArdesD. GuagnanoM.T. DaviG. Metabolic syndrome: Sex-related cardiovascular risk and therapeutic approach.Curr. Med. Chem.201724242602262710.2174/092986732466617071012114528699503
     [Google Scholar]
  98. GerdtsE. ZagrosekR.V. Sex differences in cardiometabolic disorders.Nat. Med.201925111657166610.1038/s41591‑019‑0643‑831700185
     [Google Scholar]
  99. Institute of MedicineSleep Disorders and Sleep Deprivation: An Unmet Public Health Problem.Washington, DCThe National Academies Press2006140410.17226/11617
     [Google Scholar]
  100. SateiaM. International classification of sleep disorders-third edition: Highlights and modifications.Chest201414651387139410.1378/chest.14‑0970
     [Google Scholar]
  101. Theorell-HaglöwJ. MillerC.B. BartlettD.J. YeeB.J. OpenshawH.D. GrunsteinR.R. Gender differences in obstructive sleep apnoea, insomnia and restless legs syndrome in adults – What do we know? A clinical update.Sleep Med. Rev.201838283810.1016/j.smrv.2017.03.00328495359
     [Google Scholar]
  102. JoffeH. MasslerA. SharkeyK. Evaluation and management of sleep disturbance during the menopause transition.Semin. Reprod. Med.201028540442110.1055/s‑0030‑126290020845239
     [Google Scholar]
  103. KrishnanV. CollopN.A. Gender differences in sleep disorders.Curr. Opin. Pulm. Med.200612638338910.1097/01.mcp.0000245705.69440.6a17053485
     [Google Scholar]
  104. YaffeK. YaffeK. ByersA.L. McCormickM. SchaeferC. WhitmerR.A. Midlife vs late-life depressive symptoms and risk of dementia: Differential effects for Alzheimer disease and vascular dementia.Arch. Gen. Psychiatry201269549349810.1001/archgenpsychiatry.2011.148122566581
     [Google Scholar]
  105. BrommelhoffJ.A. GatzM. JohanssonB. McArdleJ.J. FratiglioniL. PedersenN.L. Depression as a risk factor or prodromal feature for dementia? Findings in a population-based sample of Swedish twins.Psychol. Aging200924237338410.1037/a001571319485655
     [Google Scholar]
  106. DafsariF.S. JessenF. Depression—An underrecognized target for prevention of dementia in Alzheimer’s disease.Transl. Psychiatry202010116010.1038/s41398‑020‑0839‑132433512
     [Google Scholar]
  107. HarozE.E. RitcheyM. BassJ.K. KohrtB.A. AugustinaviciusJ. MichalopoulosL. BurkeyM.D. BoltonP. How is depression experienced around the world? A systematic review of qualitative literature.Soc. Sci. Med.201718315116210.1016/j.socscimed.2016.12.03028069271
     [Google Scholar]
  108. JangY. SmallB.J. HaleyW.E. Cross-cultural comparability of the Geriatric Depression Scale: Comparison between older Koreans and older Americans.Aging Ment. Health200151313710.1080/1360786002002061811513010
     [Google Scholar]
  109. KesslerR. McGonagleK.A. SwartzM. BlazerD.G. NelsonC.B. Sex and depression in the National Comorbidity Survey I: Lifetime prevalence, chronicity and recurrence.J. Affect. Disord.1993292-3859610.1016/0165‑0327(93)90026‑G8300981
     [Google Scholar]
  110. ShorsT.J. MillonE.M. ChangH.Y.M. OlsonR.L. AldermanB.L. Do sex differences in rumination explain sex differences in depression?J. Neurosci. Res.2017951-271171810.1002/jnr.2397627870434
     [Google Scholar]
  111. NiestersM. DahanA. KestB. ZacnyJ. StijnenT. AartsL. SartonE. Do sex differences exist in opioid analgesia? A systematic review and meta-analysis of human experimental and clinical studies.Pain20101511616810.1016/j.pain.2010.06.01220692097
     [Google Scholar]
  112. KumaradevS. FayosseA. DugravotA. DumurgierJ. RouxC. KivimäkiM. Singh-ManouxA. SabiaS. Timeline of pain before dementia diagnosis: A 27-year follow-up study.Pain202116251578158510.1097/j.pain.000000000000208033003109
     [Google Scholar]
  113. JessenF. GeorgesJ. WortmannM. What matters to patients with alzheimer’s disease and their care partners? implications for understanding the value of future interventions.J Prev Alz Dis20223955055510.14283/jpad.2022.22
     [Google Scholar]
  114. AshrafizadehH. GheibizadehM. RassouliM. HajibabaeeF. RostamiS. Explain the experience of family caregivers regarding care of alzheimer’s patients: A qualitative study.Front. Psychol.20211269995910.3389/fpsyg.2021.69995934248803
     [Google Scholar]
  115. VanciniR.L. dos AndradeS.M. de LiraA.B.C. NikolaidisT.P. KnechtleB. Is it possible to age healthy performing ultra-endurance exercises?Int. J. Sport Stud. Health.202241e12290010.5812/intjssh.122900
     [Google Scholar]
  116. SiahpooshM.B. Ben SaadH. GholibeygiS. Avicenna’s views on lifestyle recommendations for the elderly: Strategies to address age-related sarcopenia.Health Nexus2023111310.61838/kman.hn.1.1.1
     [Google Scholar]
/content/journals/cas/10.2174/0118746098299754240530111755
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Connecting the Dots: Gender, Sexuality, and Societal Influences on Cognitive Aging and Alzheimer's Disease
Curr Aging Sci 18, 14 (2025); https://doi.org/10.2174/0118746098299754240530111755
/content/journals/cas/10.2174/0118746098299754240530111755
/content/journals/cas/10.2174/0118746098299754240530111755
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  • Article Type:     Review Article
Keyword(s): ADRD; Alzheimer’s; APOE; dementia; gender; neuropsychiatric; sexual hormones

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