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Volume 18, Issue 1
  • ISSN: 1874-6098
  • E-ISSN: 1874-6128

Abstract

Background

Acute disseminated encephalomyelitis (ADEM) is a neural and immune-related disorder that occurs when the cerebrospinal system is damaged by extensive swelling. Although manifestation is possible regardless of age, adolescents have a greater probability. The purpose of the present manuscript is to provide recent advancements and enhance knowledge of the disease.

Methods

The literature search on etiology, pathophysiology, diagnosis and treatment was carried out using the online databases of SciFinder, Medline, Pubmed, GoogleScholar, Scopus, .

Results

Although the cause of ADEM remains unclear, it is believed to be caused by inflammation in those with a genetic sensitivity to environmental stimulation. When people have altered levels of awareness or multifocal neurological abnormalities, ADEM is a possibility as a diagnosis. The diagnosis of ADEM is dependent on a combination of clinical and radiologic symptoms, whereas the exclusion of illnesses mimics ADEM; there is no one test that can establish the diagnosis. The inflammation in a child's brain and spinal cord is treated with medication. Prednisone is occasionally given to youngsters for a brief amount of time.

Conclusion

Most children with ADEM improve with high doses of methylprednisolone. Cyclophosphamide is needed by individuals with hypothermia. Most investigations show that 50%-75% of individuals completely recover between the first and sixth month of their condition.

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An Insight into Disseminated Acute Encephalomyelitis Pathogenesis and Treatment -A Review
Curr Aging Sci 18, 1 (2025); https://doi.org/10.2174/0118746098294208240429091631
/content/journals/cas/10.2174/0118746098294208240429091631
/content/journals/cas/10.2174/0118746098294208240429091631
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  • Article Type:     Review Article
Keyword(s): Acute disseminated encephalomyelitis; central nervous system; cerebrospinal fluid; clinical; neurological abnormalities; prednisone; radiologic features; treatment

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