Current Alzheimer Research - Volume 19, Issue 5, 2022

Background: There is a well-described mechanism of communication between the brain and gastrointestinal system in which both organs influence the function of the other. This bi-directional communication suggests that disease in either organ may affect function in the other. Objective: To assess whether the evidence supports gastrointestinal system inflammatory or degenerative pathophysiology as a characteristic of Alzh Read More

Background: Traumatic brain injury (TBI) has been associated with an increased likelihood of late-life dementia; however, the mechanisms driving this relationship are elusive. Bloodbased biomarkers may provide insight into these mechanisms and serve as useful prognostic indicators of cognitive recovery or decline following a TBI. Objective: The aim of this study was to examine blood biomarkers within one year of TBI a Read More

Background: Caring for a family member with dementia is stressful and challenging. Family caregivers, as a vulnerable marginalized population and invisible backbone of the health care system, need accessible and effective interventions that are tailored to their particular needs. Objectives: The objective of this study was to evaluate the feasibility and effectiveness of a live online mindfulness-based cognitive therapy (tele-MBCT) i Read More

Background: The development of automatic speech recognition (ASR) technology allows the analysis of temporal (time-based) speech parameters characteristic of mild cognitive impairment (MCI). However, no information has been available on whether the analysis of spontaneous speech can be used with the same efficiency in different language environments. Objective: The main goal of this international pilot study is to addr Read More

Background: Alzheimer's disease (AD) is a progressive neurodegenerative disease affecting the elderly, characterized by decreased cognitive function. Non-coding RNAs contribute to AD pathogenesis. Objective: To identify potential therapeutic targets for AD, competing endogenous RNA (ceRNA) networks were constructed using the hippocampus of 6-month-old amyloid precursor protein/ presenilin 1 double transgenic (A Read More