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Volume 20, Issue 7
  • ISSN: 1573-4099
  • E-ISSN: 1875-6697
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Abstract

Background

is an herbal medicine widely used in the treatment of atrial fibrillation (AF), but the mechanism is unclear.

Objective

To explore the molecular mechanism of against AF.

Methods

The TCMSP was used to screen the active compounds and their targets. Differentially expressed genes (DEGs) for AF were identified using open-access databases. Using Venn diagrams, the cross-targets of , pyroptosis, and AF were obtained. The genes underwent molecular docking as well as gene set enrichment analysis (GSEA). A nomogram based on candidate genes was constructed and evaluated with the clinical impact curve. After that, the immune infiltration of the dataset was analyzed by single sample GSEA (ssGSEA). Finally, microRNAs (miRNAs) and transcription factors (TFs) were predicted based on candidate genes.

Results

Tumor necrosis factor (TNF) and caspase-8 (CASP8) were obtained as candidate genes by taking the intersection of DEGs, targets of , and pyroptosis-related genes. Toll-like receptor (TLR) and peroxisome proliferator-activated receptor (PPAR) signaling pathways were linked to candidate genes. Additionally, immune cell infiltration analysis revealed that CASP8 was associated with natural killer T cells, natural killer cells, regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSC), macrophages, CD8 T cells, and CD4 T cells. Finally, miR-34a-5p and several TFs were found to regulate the expression of CASP8 and TNF.

Conclusion

CASP8 and TNF are potential targets of intervention in pyroptosis-related AF, and the TLR/NLRP3 signaling pathway may be associated with this process.

© 2024 Bentham Science Publishers
© 2024 The Author(s). Published by Bentham Science Publisher. This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
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2025-05-25

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/content/journals/cad/10.2174/0115734099259071231115072421
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Network Pharmacology and Bioinformatics Analyses Identify the Core Genes and Pyroptosis-related Mechanisms of Nardostachys chinensis for Atrial Fibrillation
Curr. Computeraided Drug Des. 20, 1070 (2024); https://doi.org/10.2174/0115734099259071231115072421
/content/journals/cad/10.2174/0115734099259071231115072421
/content/journals/cad/10.2174/0115734099259071231115072421
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  • Article Type:     Research Article
Keyword(s): Atrial fibrillation; bioinformatic analysis; immune cell infiltration; Nardostachys chinensis; network pharmacology; pyroptosis

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