Current Analytical Chemistry - Volume 8, Issue 1, 2012

Current Analytical Chemistry now enters in its 8th year of publication. It has become a leading journal in its field with a respectable impact factor. I would like to thank the Associate Editors, Guest Editors, Regional Editors as well as the Editorial Board Members for their constant efforts and guidance. I am also grateful to the authors for their valuable contributions.

Soon after the word “proteome” was firstly coined by Marc Wilkins in 1994 to describe the sum of proteins produced by an organism or a biological system, the term “proteomics” was coined to define the large scale study of the proteome. Ever since then, especially after the completion of the draft sequence of the human genome, various “omics (or-omes)” terms have been created to signify the study of respective “–omes” at Read More

Reversible protein phosphorylation is among the most widespread and important protein modifications in nature, regulating a vast number of key cellular signaling pathways, and deregulation of phosphorylation-mediated processes is often implicated in many human diseases including cancers. Large-scale qualitative and quantitative analysis of protein phosphorylation is thus essential for understanding these important Read More

A number of stable isotope labeling techniques have been developed and have become the most prospective approaches in the realm of shotgun differential proteomics, where mass spectrometry is often coupled with liquid chromatography for better sensitivity, efficiency and specificity. Among these stable isotope labeling techniques, 18O labeling has received growing interest in the research community due to its simplic Read More

Liquid chromatography electrospray tandem mass spectrometry (LC-ESI-MS/MS) is the primary method for sample analysis used in proteomics. The high-resolution separation of liquid chromatography (LC), coupled with the sensitivity and specificity of mass spectrometry (MS) permits the identification of thousands of peptides in a single analysis of protease digested samples. Although numerous advances have been made Read More

This review summarizes the current status of mass spectrometry (MS)-based techniques used in ginseng research. The review has been explored from two parts. The first part presents an overview of the chemical analysis of ginseng based on MS and liquid chromatography-mass spectrometry (LC-MS), including the application of MS/MS on systematic structural characterization of ginsenosides and the fragmentation patterns of Read More

Fluorescent silicon nanoparticles (silicon dots) are low-toxicity nanomaterials of utmost interest to analytical and bioanalytical chemistry. Silicon dots have proved to be excellent fluorescent tags for sensor development applications. This review focuses on silicon dots and their fluorescent properties and applications. Silicon dots can be produced via nine basic synthetic methods and their fluorescent properties differ consid Read More

Dispersive liquid-liquid microextraction (DLLME) is a novel microextraction technique with a great potential in sample pretreatment, which has been increasingly used for preconcentration of diverse analytes. This review updates the state of the art and discusses promising prospects of DLLME, especially focuses on its combined use with chromatographic techniques for organic compounds analysis in environmental water sampl Read More

The carbapenems are a group of β-lactam antibiotics. The analogs of carbapenem (imipenem, panipenem, meropenem, ertapenem, biapenem and doripenem) used in treatment have an exceptionally broad spectrum of antibacterial activity. Several carbapenems are in advanced clinical trials (tebipenem, lenapenem, sulopenem, tomopenem). The aim of this review is to present the development and applicability of the an Read More

A quick, reliable micellar electrokinetic chromatography (MEKC) method was developed and validated for the analysis of sitagliptin phosphate in tablets. Separation was carried out in fused silica capillary (48.0 cm total length and 40.0 cm effective length, 50 μm i.d.) by applying a potential of 30 kV (positive polarity), hydrodynamic injection by 50 mbar for 5 s and the temperature of the capillary cartridge was 25 °C. The select Read More

In this study the effect of the presence of some different additives on non-aqueous capillary electrophoresis (NACE) separations of some structurally related compounds belonging to beta-blockers, antidepressants or neuroleptics were examined. Presence of surfactant was found to have a strong effect on separations. The anionic surfactant sodium dodecyl sulfate (SDS) enhanced separation of neuroleptics and beta- Read More

The electrochemical study of varenicline (VAR) was done in a wide pH range (2-12), at boron doped diamond electrode (BDDE), glassy carbon electrode (GCE) and hanging mercury electrode (HMDE), using cyclic (CV), square wave (SW) and adsorptive stripping square wave (AdSSW) voltammetric techniques. Depending on the pH and the type of the working electrode the characteristic electrochemical behavior of var Read More

Advanced oxidation process (AOP) is a widely used technique in environmental remediation of pollutants. Photocatalytic oxidation processes using iron system with H2O2 involve OH radical formation, which aids the degradation of pollutants in the aqueous system. Detection of hydroxyl radical is generally done in ESR spectrometry using DMPO as the spin trapping agent. Here, Methylene Blue (MB) was chosen as the test dye an Read More

A solid-phase extraction method using mixed hemimicelles and high-performance liquid chromatographydiode array detection was proposed for the pre-concentration and determination of anthraquinones (AQs) in Radix et Rhizoma Rhei samples. The mixed hemimicelles were synthesized by coating cetyltrimethylammonium bromide (CTAB) on Fe3O4 nanoparticles. Based on the superparamagnetic character of Fe3O4 nanopa Read More

A simple and sensitive isocratic reverse-phase high performance liquid chromatography method coupled with charged aerosol detection (HPLC-CAD) was developed and validated for the determination of gabapentin concentrations in a pharmaceutical formulation and in biological samples (rat serum and urine). Biological samples were simply treated with acetonitrile and directly injected into the HPLC without any further ex Read More

For a set of 178 volatile organic compounds with highly diverse chemical structures, including terpenes, oxygenated terpenes such as esters, aldehydes, ketones, acids and alcohols, oxygenated benzene compounds, alkanes and so forth, the gas chromatographic programmed-temperature retention indices (PTRIs) have been modeled quantitatively using topological indices. A prediction model constructed by a r Read More

Angiotensin-I converting enzyme (ACE) has an important function in blood pressure regulation. ACEinhibitory peptides can lower blood pressure by inhibiting ACE activity. In this investigation, water-soluble proteins were extracted from yeast (Saccharomyces cerevisiae) and hydrolyzed by yeast protein extraction enzyme to isolate ACEinhibitory peptides. Peptides with ACE-inhibitory activity were further separated and purified by Read More