Current Analytical Chemistry - Volume 17, Issue 3, 2021

Background: Ultrasmall nanoclusters (USNCs) have attracted tremendous attention owing to their unique properties that make them desirable for the development of personalized medicine, such as tunable emission, straightforward modification, and renal clearance. Hence, USNCs have emerged as potential materials for nanotheranostics. Objective: For decades, great efforts have been devoted to the bio-applications of Read More

Background: Luminogens that feature aggregation induced emission (AIE) are typically non-emissive in solution but become highly luminescent upon aggregation in poor solvents or solid state. Discussion: Unlike conventional fluorophores that exhibit aggregation-caused quenching (ACQ), utilization of AIE luminogens as bioprobes has featured superior photostability, low background signal, large Stokes’ shifts, high sensitivit Read More

Background: Cold stress injury to plants is a highly complex process and a significant cost to agricultural food production. This stress adversely affects metabolism, growth and productivity of plants. Timely visualization of plants’ cold stress is important for identifying injury to the plants and for predicting a plant's survival. While there is a developed understanding of physiology and biology associated with this condition, early Read More

Background: The ubiquitous Lewis acid/base interactions are important in solution processes. Analytical chemistry may benefit from a better understanding of the role of Lewis basicity at the molecular level or acting through a bulk solvent effect. Objective: To delineate (i) the basicity at a molecular level, hereafter referred to as solute basicity, and (ii) the solvent basicity, which is a bulk-liquid property. Methods: The literatu Read More

Background: Over the last few decades, there has been a growing interest in Two- Dimensional Liquid Chromatography (2D-LC). This advanced technology has become a relevant solution for solving all the analytical challenges encountered in the pharmaceutical industry. The primary purpose of this review is to give a brief account of the developing techniques notable in 2D-LC. Methods: Review of recent literature on a Read More

Background: Chiral purity is a critical quality attribute of pharmaceutical materials as chiral compounds are known to exhibit different pharmacological and toxicological properties as compared to those of their enantiomers (or diastereomers for molecules with multiple chiral centers). It is important to note that about 40% of the synthetic drugs are chiral, 60% of all pharmaceuticals are chiral and 45% chiral dr Read More

Background: Neurotransmitters are chemical messengers with crucial implication in the human body. Perturbations in the concentration of neurotransmitters can affect a multitude of mental and physical functions such as heart rate, sleep, appetite and mood. Thus, the sensitive detection of these compounds is a real need for a new generation of treatments. Methods: Simultaneous detection of two important ne Read More

Background: 5-fluorouracil and resveratrol are the two most effective anticancer drugs. Combination therapy with these two drugs has shown promising results in cancer. The formulation containing 5-fluorouracil and resveratrol has been prepared, but no analytical method is available in the literature for their simultaneous estimation. However, several analytical methods are there for estimation of either 5-fluorouracil or Read More

Background: Measuring medicinal compounds to evaluate their quality and efficacy has been recognized as a useful approach in treatment. Rhubarb anthraquinones compounds (mainly including aloe-emodin, rhein, emodin, chrysophanol, and physcion) are the main effective components in purgating drug. In the current Chinese Pharmacopoeia, the total anthraquinones content is designated as its quantitative Read More

Background: Although molecularly imprinted polymers (MIPs) have now been widely utilized for the sample pre-treatment, chromatography separation and removal of pollutants, conventional MIPs still lack satisfactory compatibility with water, thus leading to poor molecular recognition for target analytes in aqueous solutions. The aim of the study was to prepare water-compatible MIPs. Methods: The zwitterionic MMIPs w Read More

Background: An electrochemical DNA biosensor based on gold nanoparticles (AuNPs) and thiol graphene (TGR) nanocomposite modified carbon ionic liquid electrode (CILE) was developed to detect a specific nuc gene of Staphylococcus aureus, which was further used in the analysis of PCR amplification samples from unfrozen pork. Objective: The development of a DNA biosensor derived from AuNPs-coated TGR could be us Read More

Background: Tramadol, (±)-trans-2-[(dimethylamino) methyl]-1-(3-methoxyphenyl) cyclohexanol, is a synthetic centrally acting analgesic used in the treatment of moderate to chronic pain. Tramadol, like other narcotic drugs, is used for the treatment of pain and may also be abused. Its overdose can cause adverse effects such as dizziness, vomiting, and nausea. The aim of this paper is to develop a sample preparation Read More