Current Analytical Chemistry - Volume 17, Issue 8, 2021

Recently, different strategies such as personalized therapy, dose adjustment, therapy monitoring and targeted drug delivery (disease-specific localization), were adopted for improving efficacy ratio of medicines that are currently in use. From a therapeutical point of view, to reach the optimal concentrations in the target organ or tissue, it is necessary to increase the administered dose, which is accompanied by an incr Read More

Background: Numerous sequencing techniques have been progressed since the 1960s with the rapid development of molecular biology studies focusing on DNA and RNA. Methods: A great number of articles, book chapters, websites are reviewed, and the studies covering NGS history, technology and applications to cancer therapy are included in the present article. Results: High throughput next-generation sequencing ( Read More

Raman Spectroscopy is on the verge of becoming a promising tool in Forensic Toxicology with the increasing number of studies in the literature. Raman Spectroscopy, which has been found successful in many areas of forensic sciences and has found its place in routine use, is gaining more importance recently in Forensic Toxicological studies especially with Surface Enhanced Raman Spectroscopy due to its fast, reliable and Read More

Background: Radiation sterilization is a promising method of obtaining sterile active pharmaceutical ingredients (API), excipients and formulations. One of the best methods of sterilization is to use ionizing radiation. The greatest advantage of ionizing radiation is the fact that it can be conducted at room temperature or lower. Therefore, this procedure of sterilization is reserved for drugs sensitive to the high temperature of autocl Read More

Background: Dopamine agonists are useful drugs for the management of patients with Parkinson's disease in the early and later stages of the disease. Parkinson's disease is a progressive neurodegenerative disease that primarily affects dopamine-producing nerve cells in the brain. They bind to dopamine receptors in nerve cells that regulate body movement and motor function. Electroanalytical methods are used in medi Read More

Background: The extraction of vitamins from complex matrices, such as pharmaceutical and biological samples, is a demanding task. Progress in material science is revolutionizing sample preparation, leading to the development of more efficient, sensitive, and selective analytical methods. In particular, the evolution of solid-phase extraction towards miniaturized techniques is closely related to the introduction of nanomaterials Read More

Background/Aim: Use of nanomaterials in healthcare applications increases in parallel to technological developments. It is frequently utilized in diagnostic procedures, medications and therapeutic implementations. Nanomaterials take place among key components of medical implants, which might be responsible for certain toxic effects on human health at nano-level. In this review, nanotoxicological effects, toxicity determinat Read More

Background: The development of innovative approaches in drug analysis is a challenging task for medicine, pharmacy, and engineering sciences. For instance, the requirement of proper dosage forms in releasing active ingredients is crucial. It is essential to analyze drugs in biological liquids for early diagnosis and treatment purposes. Drug analysis is also of great importance to control the quality of pharmaceutical products, test Read More

Background: Nanotechnology is a promising field of science which deals with the production and utilization of material under nanoscale dimensions. The nanoscale regime provides exceptional applications in various fields of science due to its large surface to volume ratio and many valuable properties. Hence, the production and use of nanomaterials are the prominent areas of modern research. Amongst the nanomaterials, Read More

Background: Gold nanoparticles (AuNPs) are commonly used in nanomedicine because of their unique spectral properties, chemical and biological stability, and ability to quench the fluorescence of organic dyes attached to their surfaces. However, the utility of spherical AuNPs for activatable fluorescence sensing of molecular processes have been confined to resonance-matched fluorophores in the 500 nm to 600 nm spectral Read More

Background: Determination of a reducing substance based on the reaction between Ce(IV) and a reducing substance and fluorescence detection of Ce(III) generated has been reported as a selective and sensitive method. However, this method could not be applied to the determination of alcohol due to the low reaction rate of alcohol and Ce(IV). Objective: We found that thiosulfate catalytically enhanced the reaction of alcohols (s Read More

Background: Folic acid (pteroylglutamic acid, FA), known as a water-soluble vitamin of B complex family, plays an important role in the human body. However, excess intake of FA would mask the vitamin B12 deficiency symptoms, which may lead to other health risks. Therefore, it is very important to develop a method for the sensitive and selective determination of FA in natural sources, fortified foods and multivitamin pr Read More