Current Analytical Chemistry - Volume 15, Issue 5, 2019

Background: Ropinirole is a non-ergot dopamine agonist indicated for Parkinson disease and restless leg syndrome. The adverse effects associated with its use are nausea (40-69%) and dizziness, etc. Objective: In order to decrease its dose-dependent adverse effects and monitoring its levels for each individual patient, a more sensitive and cost-effective monitoring techniques were in demand. Methods: Microextraction technique Read More

Background: The demand for green analytical methods is rising, mainly due its impact on the reduction of waste generation. The official method to assay Doxycycline Hiclate (DOXH) is HPLC, using an unusual column and a multi-component mobile phase. Objective: To develop a capillary electrophoresis method (CZE) to assay DOXH in suppositories and tablets. Methods: Doxycycline was analyzed in a CZE system using a f Read More

Background: Working with an Evaporative Light Scattering Detector (ELSD), the target components are converted to a suspension of particles in a gas phase by a nebulizer and heated while the mobile phase is evaporated. Then, the incident light is directed at the remaining particles which are scattered and detected. Methods: The signal response of an ELS detector is studied through the correlation of the signal intensity of 65 c Read More

Background: Formononetin is a common soy isoflavonoid that can be found abundantly in many natural plants. Previous studies have shown that formononetin possesses a variety of activities which can be applied for various medicinal purposes. Certified Reference Materials (CRMs) play a fundamental role in the food, traditional medicine and dietary supplement fields, and can be used for method validation, uncertainty esti Read More

Background: Formaldehyde is widely acknowledged as a carcinogen, but as an important organic reagent, it has also been widely employed in the fields of chemical synthesis, industrial production and biomedicine. It is therefore of great practical significance for the detection of formaldehyde in food, clothing, daily necessities, construction materials and environments. Methods: The two silicon QDs, that are, DAMO-Si-QDs (with Read More

Background: Tetrodotoxin (TTX) is a biosynthesized neurotoxin that exhibits powerful anticancer and analgesic abilities by inhibiting voltage-gated sodium channels that are crucial for cancer metastasis and pain delivery. However, for the toxin’s future medical applications to come true, accurate, inexpensive, and real-time in vivo detection of TTX remains as a fundamental step. Methods: In this study, highly purified TTX Read More

Background: The electrochemical behavior of minoxidil on gold (Au), Glassy Carbon (GCEs), and Carbon Paste Electrodes (CPEs) was investigated in an aqueous supporting electrolyte (phosphate buffer [pH 2.0-6.5], acetate buffer [pH 4.3], and Britton and Robinson buffer [pH 2.0-7.4]). Methods: For cyclic voltammetric measurements with suitable methodical parameters, CPEs catalyze electrooxidation of minoxidil more efficiently Read More

Background and Objective: Laser spectroscopy is becoming an increasingly paramount analytical tool. Scientists today have at their disposal many various types of laser-based analytical techniques. In this article, the possibility of using capabilities of a laser to analyze and find the concentration of Serum Total Protein (STP) was studied. Materials and Methods: The laser system includes a diode laser with 532 nm wavelength, with Read More

Background: Conivaptan inhibits two of vasopressin receptor (vasopressin receptor V1a and V2). Conivaptan is used for the treatment of hyponatremia, and in some instances, for the treatment of the heart failure. Methods: The present study aimed to develop a simple, sensitive, and accurate HPLC with ultraviolet detection for the assay of conivaptan (CON) in mouse plasma using bisoprolol as internal standard (IS). A Read More

Background: Heparin, it is commercially used as an anticoagulant in surgical procedures for the prevention of blood clotting. However, overdose and prolonged use of heparin often induce potentially fatal bleeding complication. So, it is of crucial importance to monitor closely heparin levels for the sake of health. In this work, a sensitive fluorescence sensing platform to detect heparin was set up based on MPA-CdSe QDs (qua Read More