Current Analytical Chemistry - Volume 15, Issue 4, 2019

Background: Macrolide antibiotics are known as versatile broad-spectrum antibiotics. Macrolides belong to the oldest group of antibacterial agents. The macrolides which are frequently used for clinical purposes are broadly categorized in three classes depending on the number of membered macrocyclic lactone ring. These three classes actually consist of 14, 15 or 16 atoms in macrocyclic lactone ring which are linked through Read More

Background: Silk fibroin is the main protein of silk, and it has recently been evaluated for drug delivery applications due to its excellent properties. Specifically, silk fibroin exhibits good biocompatibility, biodegradability and low immunogenicity. Fibroin nanoparticles have attracted attention due to their high binding ability to different drugs as well as their ability for controlled drug release. The improvement of the therapeutic effic Read More

Background: Liquid chromatography is the workhorse of analytical laboratories of pharmaceutical companies for analysis of bulk drug materials, intermediates, drug products, impurities and degradation products. This efficient technique is impeded by its long and tedious analysis procedures. Continuous efforts of scientists to reduce the analysis time resulted in the development of three different approaches namely, HTLC, chr Read More

Background: Nanotech products are gaining more attention depending on their advantages for improving drug solubility, maintenance of drug targeting, and attenuation of drug toxicity. In vitro release test is the critical physical parameter to determine the pharmaceutical quality of the product, to monitor formulation design and batch-to-batch variation. Methods: Spectrophotometric and chromatographic methods are Read More

Background: Application of electrochemical sensors for analysis of food, biological and water polluting compounds helps to speed up their analysis in the real samples. Electrochemical sensors with low cost, fast response and portable ability are a better choice compared to traditional methods for analysis of electro-active compounds such as HPLC. Therefore, in recent years, many analytical scientists have suggested this type o Read More

Background: Tricyclic psychotropic drugs are defined as a tricyclic rings of the dibenzazepine group with the presence of sulfur and nitrogen atoms. They have been prescribed for antidepressive therapy over the years. Due to their medical importance, many analytical methods have been developed for their monitoring. However, benefits of electrochemical techniques such as costeffectiveness, fast, easy operation and non Read More

Background: Catecholamine drugs are a family of electroactive pharmaceutics, which are widely analyzed through electrochemical methods. However, for low level online determination and monitoring of these compounds, which is very important for clinical and biological studies, modified electrodes having high signal to noise ratios are needed. Numerous materials including nanomaterials have been widely used as electro Read More

Background: The determination of drugs in pharmaceutical formulations and human biologic fluids is important for pharmaceutical and medical sciences. Successful analysis requires low sensitivity, high selectivity and minimum interference effects. Current analytical methods can detect drugs at very low levels but these methods require long sample preparation steps, extraction prior to analysis, highly trained technical st Read More

Electrochemical methods have been used for the determination of nonsteroidal antiinflammatory drugs (NSAID) just as used in the determination of various drugs. Among voltammetric methods; differential pulse voltammetric method, square wave voltammetric method and linear sweep voltammetric method are the most commonly used ones. NSAIDs are widely used in the treatment of inflammatory conditions such as Read More

Background: Anthrax Lethal Factor (ANT) is the dominant virulence factor produced by B. anthracis and is the major cause of death of infected animals. In this paper, pencil graphite electrodes GE were modified with single-walled and multi-walled carbon nanotubes (CNTs) for the detection of hybridization related to the ANT DNA for the first time in the literature. Methods: The electrochemical monitoring of label-free DNA hy Read More

Background: Probiotics are living microorganisms that have a healthy influence on a host. Objective: The aim of this study was to isolate a probiotic Pediococcus acidilactici strain from newborn faeces and develop and optimize a selective high-performance liquid chromatography method for the determination and validation of its lactic acid content and also evaluate some probiotic characteristics. Methods: Isolated strains were id Read More