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Volume 21, Issue 2
  • ISSN: 1573-4110
  • E-ISSN: 1875-6727

Abstract

Background

Rodents and many wild and domestic animals, including cattle, donkeys, goats, hares, ostriches, and sheep, spread the Crimean-Congo Hemorrhagic Fever Virus (CCHFV), acting as hosts for infected ticks primarily of the genus, which serve as vectors and reservoirs of the virus. CCHF is a severe, potentially lethal, and widespread disease, making it a serious public health issue. Environmental changes impacting rodent populations affect their global distribution and, therefore, play a role in the spread of CCHFV.

Objective

This study aims togain a deeper understanding of the envelope glycoproteins expressed by the CCHFV.

Methods

Multiple computational algorithms determined the Intrinsic Disorder Predisposition (PIDP), Polarity Index, and genomic profiles of each sequence of the glycoproteins.

Results

When examining the Polarity Index Method Profile, 3.0v profile, and the PIDP profile, the envelope glycoproteins of the CCHFV showed different patterns. With these patterns, it was possible to identify structural and morphological similarities.

Conclusion

With the PIM 3.0v profile, our computer programs were able to identify isolated CCHFV envelope glycoproteins. We believe that this research provides a deeper understanding of this virus.

© 2025 Bentham Science Publishers
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2024-05-22
2025-01-13

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Bioinformatics Characteristics and Genomic Patterns of the Envelope Glycoproteins of the Crimean-congo Hemorrhagic Fever Viruses
Current Analytical Chemistry 21, 106 (2025); https://doi.org/10.2174/0115734110298088240515063827
/content/journals/cac/10.2174/0115734110298088240515063827
/content/journals/cac/10.2174/0115734110298088240515063827
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  • Article Type:     Research Article
Keyword(s): Crimean-congo hemorrhagic fever virus; envelope glycoproteins; hemorrhagic disease; intrinsic disorder predisposition; mutant glycoproteins; polarity index method; polarity index method 2.0v profile; structural proteomics

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