Anti-Infective Agents - Volume 17, Issue 1, 2019

Background: Microbial infection and its resistance to clinically approved drugs create a huge threat to human health. Emerging reports have indicated the potential of statin drugs in the treatment of various types of microbial infections. However, it is still unclear, how much concentration of statin is effective against microbial infections. In literature, Minimum Inhibitory Concentration (MIC) values of statin drugs vary accordi Read More

Introduction: Tuberculosis is an infectious bacterial disease that mainly affects the lungs. Globally, there are about 10.5 million new cases and about 1.5 million deaths reported each year as per science daily research news in 2017. Objective: One of the biggest problems of Tuberculosis is the lack of effective treatments. Bedaquiline (2013) and Delaminid (2014) are the only two agents approved for TB after Rifampicin. This clearly Read More

Background: Antibiotics play an important role in the treatment of infections to the humans and at the same time, irrational, frequent prescription of higher antibiotics, change in gene composition of microorganisms are all the reasons behind the development and introduction of new antibiotics against different microorganisms. Objective: In this project, an attempt has been made to synthesize some derivatives of diazenyl contai Read More

Background: The actinomycetes strains isolated from unexplored ecosystems are a promising alternative for the biosynthesis of novel antimicrobial compounds. Depending on the interesting antifungal activity of the studied strain S19, the statistical method seems to be an effective tool for optimizing the production of anticandidal molecules. Introduction: This study was conducted in order to optimize the culture parameters Read More

Background: Neuroleptic phenothiazines have been reported for antitubercular activity, but the unwanted side effect (antipsychotic activity) restricted their use as antitubercular drugs. Objective: The study aimed to carry out development of phenothiazine based antitubercular agents by modifying/removing the chemical group(s)/ linker(s) of chlorpromazine essential for exerting an antipsychotic effect. Methods: The desig Read More

Background: Nitrogen-containing heterocyclics are abundant in natural products and also in synthetic drug molecules because of a variety of applications and superior pharmacological profile action. Pyrazoles are the integral architects of many of the heterocyclic compounds with superior biological activity. Methods: Two series of the pyrazole conjugated Benzothiazole derivatives were synthesized. The pyrazoles were synth Read More

Background: Seven compounds were isolated from Dracaena cochinchinensis and elucidated their structure by NMR spectroscopic analysis and determined the optical rotation for certain compounds. Methods: These compounds were screened for antibacterial activity by using agar well diffusion and determination of minimum inhibitory concentration (MIC) was conducted by the broth micro-dilution method using resazuri Read More