Anti-Infective Agents - Volume 13, Issue 2, 2015

Introduction: H. pylori is a flagellate Gram-negative bacterium living on the mucosal surface of the gastric epithelium. It is accepted that the antibiotic resistance is a major problem for treatment of diseases caused by infectious bacteria. Infection is generally acquired during childhood and persists life-long in the absence of antibiotic treatment. Because of development of quinolone-resistant pathogens, quinolone-based Read More

Background: The recent emergence of multi-drug resistant (MDR) and extensively drugresistant (XDR) cases of tuberculosis has lead to the search for new structural classes of anti-TB drugs that can be effective against these strains of Mycobacterium tuberculosis. In the present study a series of 2-thiazolylimino-5-arylidene-4-thiazolidinone derivatives, unsubstituted and mono-substituted with hydroxy, methoxy, fluoro, chloro an Read More

Background: Tuberculosis is responsible for the world’s leading cause of death affecting one third of the world’s population by the latent or dormant form despite the current chemotherapy. For the effective management of MDR or XDR-TB, new lead compounds or novel therapeutic targets are urgently needed. The present investigation is aimed at creating a new and hitherto unreported molecular framework encompassing isox Read More

Background/Purpose: Medicinal plant extracts with potent antimicrobial activity are potentially useful sources of new and novel antimicrobial agents. We investigated the extracts from the stem bark of Macaranga rosea antimicrobial activity. Methods: Cold extraction procedures were used to obtain extracts followed by standard qualitative assays for phytochemicals. Agar well diffusion and macrobroth dilution assays were u Read More

Background: Pyrazole, oxazole and pyrimidine are nitrogen containing heterocycles which possess very good binding efficiency with receptor or proteins. Due to this effect it can be work as antitubercular agents with active substituents. The objective of this paper is clubbed the heterocycles to enhance their antitubercular potency. Methods: The active substituted pyrazole aldehydes were synthesized by reaction of phenyl hyd Read More

Background: A series of sixteen novel isatin analogs (3a-3p) have been synthesized and evaluated for their antibacterial and antifungal activities against various pathogenic microorganisms. Gram-positive bacterial strains: Staphylococcus aureus, Bacillus subtilis; Gram-negative bacterial strains: Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, Klebsiella pneumonia, and fungal strains Candida albicans, Aspergil Read More

Background: Dihydropyrimidinone is considered as a pharmacophoric skeleton in many drug discovery programmes. To explore the activity of dihydropyrimidines, we regioselectively synthesized some of the substituted mannich bases of dihydropyrimidinone (DHPM) analogues regioselectively with fluoroquinolones (Ciprofloxacin). Methods: Regioselectivity in these structures is achieved by the influence of weak Read More