Anti-Infective Agents - Volume 12, Issue 2, 2014

With the everincreasing problem of multidrug resistance worldwide, concerns are growing regarding use of alternative compounds to supplement or modify the actions of antibiotics. Along with drug resistance, antibiotics also provide a number of side effects, diarrhea being a very prominent one. Antibiotic associated diarrhea (AAD) is difficult to manage and therefore concepts like ‘probiotics’ have gained importance. In this r Read More

Lymph node tuberculosis (TB) represents the most common form of extrapulmonary TB that affects most often laterocervical lymph nodes. The disease, favored by states of immunosuppression, manifests itself by usually unilateral swelling, which may be associated with skin changes (hyperaemia, infiltration or fistula) and poor systemic symptoms. Our study included 75 patients arrived at the hospital “V. Monaldi” of N Read More

Tuberculosis (TB) is of increasing concern due to the recent emergence and spread of MDR-TB, XDR-TB, TDR-TB and HIV/AIDS pandemic. There is urgent need for novel antitubercular agents which can shorten the treatment duration. Based on isosteric replacement and 3D structural similarity between Linezolid, an oxazolidine antimycobacterial agent, we have designed novel 4-amino-3,5-di(substituted)thiazolin-2(3H)thione/one Read More

Aim: Plant extracts or plant-derived compounds are likely to provide a valuable source of new medicinal agents. In the present work anti-leishmanial activity of methanolic extracts of Gossypium hirsutum, Ferula assa-foetida and Artemisia aucheri, was studied on Leishmania major promastigotes by colorimetric assay in comparison to a trivalent antimony compound (tartar emetic). Methods: L. major promastigotes Read More

The present study was intended to reveal the antibacterial activity of various cold organic solvent extracts of Abrus precatorius L. (Fabaceae) and Asystasia gangetica (L.) T. Anderson (Acanthaceae) against the selected pathogens. Powders of whole plant parts of A. precatorius and A. gangetica were extracted with petroleum ether, benzene, chloroform and ethanol at ambient temperature. The dried extracts were tested for anti Read More

The biological properties of medicinal plants have been documented worldwide for many centuries. However, the top priority for the biomedical field is the search for safe and effective antibacterial agents against the wide variety of bacterial infections. Therefore, the present study aimed to evaluate various phytoconstituents and in-vitro antibacterial activity of crude extracts from Aegle marmelos, Capparis aphylla, Callistem Read More

Mycobacterial infections (particularly, tuberculosis caused by Mycobacterium tuberculosis) represent a significant threat to public health, especially south of the Sahara. The problem has been compounded by poor patient compliance due to long periods of treatment, thus resulting in the development of multi-drug resistant (MDR) and extremely drugresistant (XDR) forms the of bacterium. It has, therefore, become impera Read More

The effect of sulfonamide drugs on the electrophysical properties of Escherichia coli strains B-878 and K-12 was investigated by the example of sulfacetamide sodium (sulfacyl sodium). Substantial changes in the orientational spectra of cell suspensions incubated with various concentrations of sulfacetamide sodium occurred only at the first five frequencies of the orienting electric field (740–2800 kHz). Sulfacetamide sodium Read More

The conjugation of different substituted styryl (-CH=CH-Aryl) moieties with the biologically relevant heteroaromatic scaffolds such as 4-benzylidene-2-methyloxazol-5-one, 3-methyl-1-phenylpyrazol-5-one, 2-methylbenzimidazole, 6-methyluracil afforded the newer series (four different series, 1A-3C, 2A-C, 3A-C & 4A-C) of styrene derivatives. Newer styrene derivatives were synthesized and characterized by IR, NMR (1H & 13C), Ma Read More

The aim of the study was to evaluate antibacterial and antioxidant potential of the actinomycete isolate Streptomyces cinnamonensis VITNS1 isolated from paddy field, Vellore, Tamil Nadu. The antibacterial activity of crude extract was tested against bacterial pathogens. The free radical scavenging potential of the crude extract was determined by DPPH assay. The morphological, physiological and the biochemical properti Read More